COVID-19 induced renal injury differs from that in other viral-infections
作者机构：Department of Drug Discovery and DevelopmentAuburn University Harrison School of PharmacyWalker BuildingAuburnAlabamaUSA Department of Mechanical EngineeringAuburn UniversityAuburnAlabamaUSA
出 版 物：《Emergency and Critical Care Medicine》 (急危重症医学（英文）)
年 卷 期：2022年第2卷第1期
页 面：23-31页
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：COVID-19 Kidney damage Renal damage Renal pathology
摘 要：Background:Kidney injuries caused by several viral diseases have been reported worldwide among all age groups,races,and *** particular importance is coronavirus disease 2019(COVID-19),and its prevalence in communities infecting all patient populations with symptoms ranging from asymptomatic to severe,including complications and ***:Data were acquired from PubMed,Scopus,Google Scholar,Centers for Disease Prevention and Control(CDC),and Lexi-Comp using the following search terms:“COVID-19 and renal pathology,“COVID-19 induced kidney disease,“Viral infection induced kidney disease,and“Viral infection induced renal damage.Titles and abstracts were manually analyzed as per the exclusion and inclusion criteria of relevant articles;relevance of articles included studies on the pathology of a specific viral infection and the impact of the virus on the adult renal ***:The mechanisms for renal disease due to COVID-19 include direct renal tubular injury,cytokine storm,inflammation,thrombosis *** tubular necrosis,thrombotic events,and direct renal *** some mechanisms behind renal dysfunction among the studied viral infections are similar,the prevalence rates of kidney injury or damage *** might be described by recommended prophylactic and therapeutic approaches that can alter the viral infection characteristics and possibly the impact a particular organ ***:The patient population at risk was old in age and had a high body mass *** mechanisms associated with renal dysfunction are similar,including direct renal injury through angiotensin converting enzyme 2(ACE2)entry,inflammation,and *** renal pathology of coronaviruses that differs from that of other prevalent viral infections is the activation of cytokine storm,which causes elevations of a greater number and different kinds of cytokines than other viral infections.
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