检索结果-南通市图书馆

检索条件"主题词=Regulatory T cells"

共 137 条记录，以下是131-140 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Polylysine-modified DNA vaccine showed elevated prophylactic and therapeutic effects in peanut allergy in mice

Polylysine-modified DNA vaccine showed elevated prophylactic...

引用

第十一届全国免疫学学术大会

作者： Zhu Zhenlai Sun Shuhong Niu Yuan Li Wei Department of Dermatology Xijing HospitalFourth Military Medical University

Objective:the prevalence of food allergy has been increasing,but the treatment is very limited.DNA vaccination hasbeen recognized as a promising method for the treatment of allergic diseases;however,poor immunogenicity has hindered its application.In the present study,we assessed the prophylactic and therapeutic effects of poly-L-lysine(PLL)-pretreated DNA vaccine encoding the major peanut allergen Ara h 2 in mice.Methods:BALB/c mice were intradermally injected with plasmid DNA encoding the peanut protein Ara h 2(p Ara h 2) or p Ara h 2 pre-treated with PLL before or after sensitization with Ara h 2 protein.Ara h 2-specific antibodies were measured by ELISA.Langerhans cells(LCs) and treg cells in draining lymph nodes were analyzed by flow cytometry after DNA immunization,and IL-10 production in splenocytes was also analyzed.Results:In the prophylactic study,pre-treatment with p Ara h 2 or PLL-p Ara h 2 resulted in lower level of Ara h 2-specific Ig G1,Ig G2 a and Ig E after sensitization with Ara h 2 protein,and mice in PLL-p Ara h 2 group showed significantly lower level of antibodies than that of p Ara h 2.In the treatment study,intradermal injection with p Ara h 2 or PLL-p Ara h 2 after Ara h 2 protein sensitization significantly decreased the level of Ara h 2-specific antibodies,and PLL-p Ara h 2 had stronger effects than p Ara h 2.there were increased numbers of LCs and treg cells in the mice receiving intradermal injection with PLL-p Ara h 2,and splenocytes from PLL-p Ara h 2-treated mice secreted increased level of IL-10.Conclusions:Modification of pA ra h 2 with PLL improved its prophylactic and therapeutic effects in peanut allergy in mice.

关键词： Ara h 2 Allergy vaccines Peanut allergy Polylysine regulatory t cells

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Correlation between tregs and glycolysis in pancreatic cancer:a mini-review

Correlation between tregs and glycolysis in pancreatic cance...

引用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： Yangyang Lei Shanshan Gao Jianke Li tianzhu Yu Ningzi tian Zhiyuan Zheng Guoping Li Xiaolin Wang 上海市影像医学研究所复旦大学附属中山医院介入治疗科

regulatory t cells（tregs） are a subset of t cells that control the autoimmune response and maintain the immune homeostasis. tregs could acquire an activated phenotype and enhanced immunosuppressive function after being reprogrammed within the tumor microenvironment（tME）. Pancreatic ductal adenocarcinoma（PDAC） is a heterogenous neoplasm with highly immunosuppressive. tregs infiltration is one of the significant features of PDAC. the relative increase in the number of tregs is closely related to the immunosuppression and disease progression of pancreatic cancer patients.Notably, enhanced glycolysis is increasingly considered to be a key hallmark of pancreatic cancer.Recent studies revealed that glycolysis promoted the pancreatic cancer progression and enhanced chemotherapy resistance. the deterioration of glycolysis has a positive effect on tregs differentiation and function, while reducing the tregs clonal expansion and migratory capacity. Understanding the role of glycolysis in tregs activities will aid us explore how metabolic reprogramming modifies tregs to meet their energy demands. Investigation of the association between tregs and glycolysis would offer a new insight for pancreatic cancer immunotherapy.

关键词： Glycolysis Immunotherapy Pancreatic ductal adenocarcinoma regulatory t cells tumor microenvironment

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Platelet promotes allergic asthma through the expression of CD154

Platelet promotes allergic asthma through the expression of ...

引用

第九届全国免疫学学术大会

作者： Jun tian tianyi Zhu Juan Liu Zhenhong Guo Xuetao Cao Institute of Immunology Zhejiang University School of Medicine National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences

Platelet activation is associated with multiple immune responses and the development of various immune-related diseases.Yet the exact role of platelet in progression of allergic asthma remains largely unclear.In this study,we demonstrate that during antigen sensitizing,platelet can be activated by OVA aerosol by upregulation of CD154(CD40L).Platelet promotes asthma progression as demonstrated by more severe leukocyte infiltration and lung inflammation,elevated IgE production and strengthened th2 responses in asthma-induced mice after platelet transfer as well as compromised disease progression after platelet depletion.Cd154 deficient platelet failed to promote asthma development,indicating the requirement of CD154 for platelet promoting asthma progression.Finally we found platelet inhibits treg differentiation partially through CD154 both in vivo and in vitro,which may explain the increase of th2 responses by platelet transfer.Our study reveals the previously unknown role of platelet CD154 in promotion of asthma development and regulation of th2 responses and treg differentiation,providing potential clues for intervention of allergic diseases.

关键词： platelet CD154 allergic asthma t helper 2 cells regulatory t cells

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Human hepatocellular carcinoma-infiltrating CD4+CD69+Foxp3-regulatory t cell suppresses t cell response via membrane-bound tGF-β1

Human hepatocellular carcinoma-infiltrating CD4+CD69+Foxp3-r...

引用

第十四届全国肿瘤生物治疗大会

作者： Yanmei Han Yan Gu Zhengping Jiang Yanfang Liu National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

tumors can recruit, induce and expand regulatory t cells(tregs) to suppress anti-tumor immune responses for survival and progression. the complicated tumor-related treg subsets and their functional mechanisms are not fully addressed yet. We have previously identified a novel CD4+CD69+CD25-Foxp3- treg subset in tumor-bearing mice, which suppresses CD4 t cell response via membrane-bound tGF-β1(mt GF-β1) and then promotes tumor progression. In hepatocellular carcinoma patients, here we identified tumor-infiltrating human CD4+CD69+ tregs which represent 7.2% of tumor-infiltrating CD4 t cells, significantly higher than conventional CD4+CD25+Foxp3+ tregs. they expressed mt GF-β1, PD-1 and CtLA-4, but not CD25 or Foxp3, only produced a little IL-10 and tGF-β1. More importantly, they significantly suppressed CD4 t cell response via mt GF-β1 in vitro. Furthermore, the percentage of these CD4+CD69+ tregs in tumor tissue was significantly correlated with tumor progression, with more pronounced at late stage of cancer patients. thus we have identified a tumor-induced new population of human CD4+CD69+ tregs in cancer patients, with phenotype of CD25-Foxp3-mt GF-β1+CtLA-4+PD-1+, and these tregs can suppress anti-tumor immune response via mt GF-β1. Our results not only enrich the family of treg subsets, providing new mechanistic insight to tumor-induced immune suppression in human, but also suggest a potential target for cancer immunotherapy.

关键词： regulatory t cells CD69 transforming growth factor-β1 tumor immune escape hepatocellular carcinoma

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Peptide tk-PQ induces immunosuppression in skin allogeneic transplantation via increasing Foxp3+ treg and impeding nuclear translocation of NF-κB

Peptide Tk-PQ induces immunosuppression in skin allogeneic t...

引用

第十三届全国免疫学学术大会

作者： Yue Wang Qing Li Lin Zhou Xuping Ding Dan Liu Zhenzhen Xun Liming Lu Shanghai chest hospital Shanghai Jiao tong University School of Medicine

Solid organ transplantation is used as the last resort for patients with end-stage disease, but allograft rejection is an unsolved problem. Here, we showed that tk-PQ, a peptide derived from trichosanthin, had an immunesuppressive effect without obvious cytotoxicity in vitro and in a mouse skin allo-transplantation model. In vitro, treatment of tk-PQ administrated type 2 t helper cell(th2)/regulatory t-cell(treg) cytokines, and increased the ratio of CD4+CD25+Foxp3+ treg by repressing the PI3 K/mtOR pathway. In addition, tk-PQ decreased NF-κB activation to downregulate proinflammatory cytokines. tk-PQ treatment in the mouse skin transplantation model also caused the similar molecular and cellular phenotypes. Furthermore, tk-PQ enhanced the suppressive function of treg by increasing Foxp3 expression, and substantially improved allograft survival. these finding demonstrate that tk-PQ has the potential to be used in clinical allogeneic transplantation.

关键词： Peptide of trichosanthin Immune rejection regulatory t cells NF-κB pathway Skin transplantation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

treg/th17 imbalance-mediated neuroinflammation is involved in pathogenesis of Parkinson's disease

Treg/Th17 imbalance-mediated neuroinflammation is involved i...

引用

中国神经科学学会第十届全国学术会议

作者： Yu-Ping PENG Zhan LIU Yan HUANG Yi-Hua QIU Department of Physiology School of MedicineNantong University

Objective Neuroinflammation has been presented as a new pathogenesis of Parkinson’s disease(PD) in recent decade.Research on this aspect has paid much attention to microglia and astrocytes,the innate immune cells in the brain.However,role of adaptive immune cells,such as CD4 t cells,in PD initiation and progression is less known due to a limit by the traditional concept mat the brain is a site of adaptive immune privilege.regulatory t(treg) cells and helper t 17(thl7) cells are two recently found subsets of CD4 t lymphocytes.Generally,the two subsets of t cells have opposite effects,immunosuppressive for treg cells and pro-inflammatory for thl7 cells.Almough it has been reported that t cells also exist in certain regions of the brain even under healthy conditions and that an imbalance in treg/thl7 cells is involved in pauiagenesis of autoimmune diseases,such as rheumatoid arthritis and multiple sclerosis,whether the treg/thl7 imbalance-mediated neuroinflammation also participates in PD pathogenesis and what mechanisms explain the actions of treg/thl7 cells on PD initiation and progression are not clear.thus,in the present study,we firstly identified the neuroinflammation mediated by imbalance in treg/thl7 cells in PD brain,secondly revealed a direct-contact molecular mechanism underlying prevention of dopaminergic neuronal loss by treg cells or aggravation of dopaminergic neuronal loss by thl7 cells,and lastly demonstrated a therapic effect of adoptively transferring treg cells into PD body on PD motor and pathology.this study provides a rationale basis for better understanding of PD pathogenesis and for design of new therapeutic strategies of PD at the anti-inflammatory profile.Methods C57BL/6 mice were injected intraperitoneally with l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine(MPtP) to prepare PD model.On days 2 and 7 following the MPtP injection,animal behavior was detected by rota-rod and open field tests,and dopaminergic neuronal loss was estimated by tyrosine hydroxylase(tH) expression in the substantia ni

关键词： Parkinson’s disease regulatory t cells helper t 17 cells neuroinflammation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human treg compartment

Single-cell transcriptomic analysis reveals disparate effect...

引用

第十四届全国免疫学学术大会

作者： Yuechen Luo Changlu Xu Bing Wang Qing Niu Xiuhua Su Yingnan Bai Shuxian Zhu Chunxiao Zhao Yunyan Sun Jiali Wang Xiaolei Sun Maolan Liu Ge Song Haidong Cui Xiaoli Chen Huifang Huang Haikun Wang Mingzhe Han Erlie Jiang Lihong Shi Xiaoming Feng State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Novogene Co. Ltd. Hangzhou First People's Hospital Ganzhou Key Laboratory of Molecular Medicine the Affiliated Ganzhou Hospital of Nanchang University Central Laboratory Fujian Medical University Union Hospital CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of Shanghai

Human FOXP3 regulatory t(treg) cells are central to immune tolerance. However, their heterogeneity and differentiation remain incompletely understood. Here we use single-cell RNA and t cell receptor sequencing to resolve treg cells from healthy individuals and patients with or without acute graft-versus-host disease(aGVHD) who undergo stem cell transplantation. these analyses, combined with functional assays, separate treg cells into na?ve, activated, and effector stages, and resolve the HLA-DR, LIMS1, highly suppressive FOXP3, and highly proliferative MKI67 effector subsets. trajectory analysis assembles treg subsets into two differentiation paths(I/II) with distinctive phenotypic and functional programs, ending with the FOXP3 and MKI67 subsets, respectively. transcription factors FOXP3 and SUB1 contribute to some Path I and Path II phenotypes, respectively. these FOXP3 and MKI67 subsets and two differentiation pathways are conserved in transplanted patients, despite having functional and migratory impairments under aGVHD. these findings expand the understanding of treg cell heterogeneity and differentiation and provide a single-cell atlas for the dissection of treg complexity in health and disease.(Nat Commun. 2021 Jun 23;12(1):3913)

关键词： regulatory t cells Single-cell RNA and t cell receptor sequencing Graft-versus-host disease Differentiation paths

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共14页 << < 5 6 7 8 9 10 11 12 13 14 > >> 跳转到页

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：