Correlation between tregs and glycolysis in pancreatic cancer:a mini-review
作者单位：上海市影像医学研究所 复旦大学附属中山医院介入治疗科
会议名称：《2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...》
会议日期：2021年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Glycolysis Immunotherapy Pancreatic ductal adenocarcinoma Regulatory T cells Tumor microenvironment
摘 要：Regulatory T cells（Tregs） are a subset of T cells that control the autoimmune response and maintain the immune homeostasis. Tregs could acquire an activated phenotype and enhanced immunosuppressive function after being reprogrammed within the tumor microenvironment（TME）. Pancreatic ductal adenocarcinoma（PDAC） is a heterogenous neoplasm with highly immunosuppressive. Tregs infiltration is one of the significant features of PDAC. The relative increase in the number of Tregs is closely related to the immunosuppression and disease progression of pancreatic cancer ***, enhanced glycolysis is increasingly considered to be a key hallmark of pancreatic *** studies revealed that glycolysis promoted the pancreatic cancer progression and enhanced chemotherapy resistance. The deterioration of glycolysis has a positive effect on Tregs differentiation and function, while reducing the Tregs clonal expansion and migratory capacity. Understanding the role of glycolysis in Tregs activities will aid us explore how metabolic reprogramming modifies Tregs to meet their energy demands. Investigation of the association between Tregs and glycolysis would offer a new insight for pancreatic cancer immunotherapy.