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Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche

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World Journal of Stem Cells 2023年第7期15卷 768-780页

作者： Guo-Kun Zhang Jing Ren Ji-Ping Li Dong-Xu Wang Sheng-Nan Wang Li-Yan Shi Chun-Yi Li Institute of Antler Science and Product Technology Changchun Sci-Tech UniversityChangchun 130600Jilin ProvinceChina College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118Jilin ProvinceChina China-Japan Union Hospital Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND Scar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound *** studies have indicated that antler reserve mesenchyme(RM)cells and their conditioned medium improved regenerative wound healing with partial recovery of cutaneous *** To develop hydrogels from the antler RM matrix(HARM)and evaluate the effect on wound *** We prepared the hydrogels from the HARM via enzymatic solubilization with *** we investigated the therapeutic effects of HARM on a full-thickness cutaneous wound healing rat model using both local injections surrounding the wound and topical wound *** The results showed that HARM accelerated wound healing rate and reduced scar ***,HARM stimulated the regeneration of cutaneous appendages and blood vessels,and reduced collagen fiber *** study showed that these functions might be achieved via creating a fetal-like niche at the wound *** levels of fetal wound healing-related genes,including Collagen III and TGFβ3 treated with HARM were all increased,while the expression levels of Collagen I,TGFβ1,and Engrailed 1 were decreased in the ***,the number of stem cells was increased in the fetal-like niche created by HARM,which may contribute to the regeneration of cutaneous *** Overall,we successfully developed an injectable hydrogel made from antler RM matrix for the regenerative repair of full-thickness cutaneous *** uncovered the molecular mechanism of the hydrogels in promoting regenerative wound healing,and thus pave the way for HARM to be developed for the clinic use.

关键词： Hydrogel Antler reserve mesenchyme regenerative wound healing Fetal-like niche

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In situ Injectable Tetra-PEG Hydrogel Bioadhesive for Sutureless Repair of Gastrointestinal Perforation

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Chinese Journal of Chemistry 2023年第23期41卷 3339-3348页

作者： Shurong Li Yiwen Xian Gang He Luyuan Chen Zhihui Chen Yonglong Hong Chong Zhang Decheng Wu Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical EngineeringSouthern University of Science and TechnologyNo.1088 Xueyuan AvenueNanshan DistrictShenzhenGuangdong518055 China These authors contribute equally. Stomatology Center Shenzhen HospitalSouthern Medical UniversityNo.1333 New RoadBaoan DistrictShenzhenGuangdong518101 China

Hydrogel bioadhesives represent promising and efficient alternatives to sutures or staples for gastrointestinal(GI)perforation ***,several concerns remain for the existing bioadhesives including slow and/or weak adhesive,poor mechanical strength,low biocompatibility,and poor biodegradability,which largely limit their clinical application in GI perforation *** this work,we introduce an in situ injectable Tetra-PEG hydrogel bioadhesive(SS)composed of tetra-armed poly(ethylene glycol)amine(Tetra-PEG-NH2)and tetra-armed poly(ethylene glycol)succinimidyl succinate(Tetra-PEG-SS)for the sutureless repair of GI *** SS hydrogel exhibits rapid gelation behavior and high burst pressure and is capable of providing instant robust adhesion and fluid-tight sealing in the ex vivo porcine intestinal and gastric ***,the succinyl ester linkers in the SS hydrogel endow the bioadhesive with suitable in vivo degradability to match the new GI tissue *** in vivo evaluation in the rat GI injured model further demonstrates the successful sutureless sealing and repair of the intestine and stomach by the SS hydrogel with the advantages of neglectable postsurgical adhesion,suppressed inflammation,and enhanced ***,our results support potential clinical applications of the SS bioadhesive for the high-efficient repair of GI perforation.

关键词： Gastrointestinal perforation Bioadhesives Gels Biological activity Sutureless repair regenerative wound healing

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