Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche
作者机构：Institute of Antler Science and Product TechnologyChangchun Sci-Tech UniversityChangchun 130600Jilin ProvinceChina College of Chinese Medicinal MaterialsJilin Agricultural UniversityChangchun 130118Jilin ProvinceChina China-Japan Union HospitalJilin UniversityChangchun 130033Jilin ProvinceChina
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第7期
页 面：768-780页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学]
基 金：Supported by the Natural Science Foundation of Jilin Province,No.YDZJ202301ZYTS508 National Natural Science Foundation of China,No.U20A20403 Doctoral Research Start-Up Fund of Changchun Sci-Tech University,No.202303 Young Scientific and Technological Talents Support Project of Jilin Province,No.QT202203 Strategic Research and Consulting Project of Chinese Academy of Engineering,No.JL2022-05
主 题：Hydrogel Antler reserve mesenchyme Regenerative wound healing Fetal-like niche
摘 要：BACKGROUND Scar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound *** studies have indicated that antler reserve mesenchyme(RM)cells and their conditioned medium improved regenerative wound healing with partial recovery of cutaneous *** To develop hydrogels from the antler RM matrix(HARM)and evaluate the effect on wound *** We prepared the hydrogels from the HARM via enzymatic solubilization with *** we investigated the therapeutic effects of HARM on a full-thickness cutaneous wound healing rat model using both local injections surrounding the wound and topical wound *** The results showed that HARM accelerated wound healing rate and reduced scar ***,HARM stimulated the regeneration of cutaneous appendages and blood vessels,and reduced collagen fiber *** study showed that these functions might be achieved via creating a fetal-like niche at the wound *** levels of fetal wound healing-related genes,including Collagen III and TGFβ3 treated with HARM were all increased,while the expression levels of Collagen I,TGFβ1,and Engrailed 1 were decreased in the ***,the number of stem cells was increased in the fetal-like niche created by HARM,which may contribute to the regeneration of cutaneous *** Overall,we successfully developed an injectable hydrogel made from antler RM matrix for the regenerative repair of full-thickness cutaneous *** uncovered the molecular mechanism of the hydrogels in promoting regenerative wound healing,and thus pave the way for HARM to be developed for the clinic use.
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