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Huoxue Tongjiang decoction-resisted reflux esophagitis by activation stem cell factor/c-kit/interstitial cell of cajal pathway and regulating the T-helper 17/regulatory T-cells balance in rats

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Traditional Medicine Research 2024年第12期9卷 1-12页

作者： Yan Liu Yan-Ping Tang Pei-Cai Li Lei Liu Xi Liu Si-Yu Liu Lei Yang Division of Gastroenterology Hospital of Integrated Chinese and Western MedicineTianjin University of Traditional Chinese MedicineTianjin 300000China Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair Hospital of Integrated Chinese and Western MedicineTianjin 300000China Institute of Integrative Medicine for Acute Abdominal Diseases Hospital of Integrated Chinese and Western MedicineTianjin 300000China

Background:Huoxue Tongjiang decoction(HXTJD)is an effective prescription for treating reflux esophagitis(RE).We investigated the effects of HXTJD on esophageal motility and mucosal inflammation in a rat RE ***:Chemical composition of HXTJD was analyzed by ultrahigh-performance liquid chromatography Q-Orbitrap mass spectrometry(MS).The change rates of mean contraction tension forces,mean amplitudes,and mean frequencies for the lower esophageal sphincter(LES)were recorded using the isolated tissue bath system,mechanical tension transducer,and PowerLab physiological *** weighing the stomach,the phenol red labeling method was used to measure the gastric emptying *** LES ultrastructure was observed through transmission electron *** and western blotting were used to detect the number of interstitial cells of Cajal(ICC)and the expression levels of c-kit protein,connexin43(Cx43),and stem cell factor(SCF).Flow cytometric analysis and enzyme-linked immunosorbent assay were conducted to detect the percentages of T helper 17(Th17)cells and regulatory T(Treg)cells and the serum concentrations of interleukin 6(IL-6),interleukin 17(IL-17),and interleukin 10(IL-10)in the ***:We identified 28 chemical constituents in *** esophageal motility,we revealed that HXTJD increased the mean contraction tension forces,mean amplitudes,and mean frequency change rate of LES and the gastric emptying rate;decreased stomach weight;and improved the LES ***,HXTJD increased the number of ICC-positive cells,and c-kit,Cx43,and SCF expression *** esophageal inflammation,HXTJD significantly decreased the percentage of Th17 cells,and IL-6 and IL-17 concentrations,and increased the percentage of Treg cells and IL-10 ***:HXTJD was found to be efficacious in the rat RE *** may promote esophageal motility and alleviate the inflammatory response by activating the SCF/c-kit/ICC

关键词： Huoxue Tongjiang decoction reflux esophagitis SCF/c-kit/ICC pathway Th17/Treg cell esophageal motility mucosal inflammation

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reflux esophagitis AND AIRWAY HYPERRESPONSIVENESS

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Chinese Medical Sciences Journal 1997年第4期12卷 248-251页

作者：宋一平李国顺 First Affiliated Hospital of Shanxi Medical University Taiyuan 030001. China

Objectives’ To observe the effects of reflux esophagitis(RE) on the lung function and alrway reactivity,and study the mechanism of airway hyperresponsiveness(AHR) in patients with ***. Lung function measurements and airway provocation tests were performed in 31 RE patientsand 35 control subjects’ TXB, and PGF,. were determined in 20 cases of each ***. In RE patients the lung function was lower and the rate of AHR was higher than control sub-jects (P<0. 05). Among RE patients 25 % had higher airway sensitivity (Dminr 3u ). The TXB2 of REpatients with AHR was higher than those without AHR’ Dmin correlated significantly with TXB2 (r=0. 653, P<0. 05).Concluswhs’ RE could damage the lung function. The rate of AHR was 61 %, the high airway sensltivity was probably potential asthma, and TXB2 may play a role in the pathogenesis of AHR.

关键词： reflux esophagitis lung function airway hyperresponsiveness

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Analysis of the Effectiveness of Biling Weitong Granules Combined with Trimethoprim and Vonoprazan in The Treatment of reflux esophagitis

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Journal of Clinical and Nursing Research 2024年第3期8卷 181-186页

作者： Yalan Chen Huiqing Zhang Jingwei Kou Huiling Yu Department of Gastroenterology Affiliated Hospital of Hebei UniversityBaoding 071000China Department of Internal Medicine Qingyuan Maternal and Child Health HospitalBaoding 071000China

Objective:To analyze the effectiveness of Biling Weitong Granules(BLWTG)combined with trimethoprim and vonoprazan in treating reflux ***:Sixty patients with reflux esophagitis admitted to our hospital from March 2020 to March 2023 were selected as study subjects and randomly divided into a control group and an experimental group,with 30 cases in each *** control group received only the combination treatment of trimethoprim and vonoprazan,while the experimental group was treated with BLWTG based on the control *** acid reflux and heartburn symptom scores,quality-of-life scores,clinical efficacy,Chinese medicine symptom incidences,and the occurrence of adverse reactions before and after treatment in the two groups were ***:After treatment,the acid reflux and heartburn symptom scores of patients in the experimental group were lower than those of the treatment control group,and the quality-of-life scores were higher than those of the treatment control group(P0.05).Conclusion:BLWTG combined with trimethoprim and vonoprazan was safe and reliable in treating reflux esophagitis,effectively relieving the symptoms and improving its clinical *** treatment is worthy of popularization.

关键词： Biling weitong granules Trimethoprim Vonoprazan reflux esophagitis

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The Therapeutic Effect of Biling Weitong Granules Combined with Oryz-Aspergillus Enzyme and Pancreatin Tablet on reflux esophagitis with Functional Dyspepsia

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Proceedings of Anticancer Research 2024年第2期8卷 46-52页

作者： Yalan Chen Ruiyao Wang Na Zhao Jie Liang Department of Gastroenterology The Affiliated Hospital of Hebei UniversityBaoding 071000China Department of Thoracic Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000China Endoscopy Center Department of GastroenterologyThe Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective:To investigate the therapeutic effect of Biling Weitong Granules combined with oryz-aspergillus enzyme and pancreatin tablets on patients with reflux esophagitis with functional ***:Sixty patients diagnosed with reflux esophagitis with functional dyspepsia who were admitted to the Affiliated Hospital of Hebei University between June 2020 and June 2023 were selected and divided into two groups:the control group and the observation group,each consisting of 30 *** control group received oryz-aspergillus enzyme and pancreatin tablets only,while the observation group received Biling Weitong Granules in addition to the *** clinical efficacy,Chinese medicine syndrome points,esophageal kinetic indexes,gastrointestinal hormone levels,and therapeutic safety of both groups were ***:The total efficiency of the observation group reached 93.33%,significantly higher than the 73.33%of the control group(P0.05).Conclusion:The combination of Biling Weitong Granules with oryz-aspergillus enzyme and pancreatin tablets demonstrates significant efficacy in the treatment of reflux esophagitis with functional dyspepsia,wi

关键词： Biling Weitong Granules Oryz-aspergillus enzyme and pancreatin tablets reflux esophagitis Functional dyspepsia

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Laryngopharyngeal reflux in patients with reflux esophagitis

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World Journal of Gastroenterology 2008年第28期14卷 4523-4528页

作者： Yung-Chih Lai Pa-Chun Wang Jun-Chen Lin Division of Gastroenterology Department of Internal Medicine Cathay General Hospital School of Medicine National Taiwan University School of Medicine Taipei Medical University Taipei 10630 Taiwan China Department of Otolaryngology Cathay General Hospital School of Medicine Fu Jen Catholic University Taipei 10630 School of Public Health China Medical University Taichung 40402 Taiwan China Department of Otolaryngology Cathay General Hospital Taipei 10630 Taiwan China

AIM: To assess the prevalence of laryngopharyngeal reflux (LPR) in patients with reflux esophagitis and dis-close factors contributing to the development of LPR. METHODS: A total of 167 patients who proved to have reflux esophagitis by endoscopy were enrolled. They received laryngoscopy to grade the reflux find-ings for the diagnosis of LPR. We used validated ques-tionnaires to identify the presence of laryngopharyn-geal symptoms, and stringent criteria of inclusion to increase the specificity of laryngoscopic findings. The data of patients were analyzed statistically to find out factors related to LPR. RESULTS: The prevalence rate of LPR in studied sub-jects with reflux esophagitis was 23.9%. Age, hoarse- ness and hiatus hernia were factors significantly as-sociated with LPR. In 23 patients with a hiatus hernia, the group with LPR was found to have a lower trend of esophagitis grading. CONCLUSION: Laryngopharyngeal reflux is present in patients with reflux esophagitis, and three predicting factors were identified. However, the development of LPR might be different from that of reflux esophagi-tis. The importance of hiatus hernia deserves further study.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease reflux esophagitis

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Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis

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World Journal of Gastroenterology 2005年第12期11卷 1793-1797页

作者： HajimeIsomoto YuseiKanazawa YoshitoNishi Chun-YangWen KenichiroInoue ShigeruKohno SecondDepartmentofInternalMedicine NagasakiUniversitySchoolofMedicine1-7-1SakamotoNagasakiJapan DepartmentofMolecularPathology AtomicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineSakamoto12-4NagasakiJapan SunkaikaiInoueHospital 8-9TakaramachiNagasakiJapan

AIM: Interleukin 8 (IL-8) mediates neutrophil trafficking via its receptors. Recent studies have shown that IL-8 is likely involved in the development and progression of erosive reflux esophagitis (RE), yet little is known about the two distinct receptors, CXC receptor (CXCR)-1 and -*** purpose of this study was to determine CXCR-1 and -2 messenger RNA expression levels in ***: We studied 26 patients with RE and 15asymptomatic controls. Paired biopsy samples were taken from the esophagus 3 cm above the gastroesophageal junction; one biopsy was snap frozen for measurement of CXCR-1 and -2 mRNA levels by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), and another was formalin-fixed for histopathological *** also examined the association of the expression levels of CXCR-1 and -2 mRNA with histopathological hallmarks of ***: The relative CXCR-1 and -2 mRNA expression levels were rather decreased in esophageal mucosa of patients with RE, compared to those in normal esophagus of controls. There were no significant difference in the relative mRNA expression levels of CXCR-1 and -2 among endoscopic grades of RE based on the Los Angeles classification. Each histopathological hallmark of GERD was not associated with the expression levels of CXCR-1 and -2 ***: Apart from overexpression of IL-8, the relative expression levels of CXCR-1 and -2 mRNA were rather lower than expected in the affected esophageal mucosa of patients with RE.

关键词： reflux esophagitis CXC receptor 1 CXC receptor 2 Interleukin 8

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Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients

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World Journal of Gastroenterology 2008年第20期14卷 3212-3217页

作者： Ken Ariizumi Tomoyuki Koike Shuichi Ohara Yoshifumi Inomata Yasuhiko Abe Katsunori Iijima Akira Imatani Tomoyoshi Oka Tooru Shimosegawa Division of Gastroenterology TohokuUniversity Graduate School of Medicine Sendai Miyagi9808574 Japan Division of Diabetes and Metabolic Diseases Tohoku University Graduate School of Medicine Sendai Miyagi 9808574 Japan

AIM： To investigate the incidence of reflux esophagitis （RE） and Hpylori infection in the diabetic patient. METHODS： The incidence of RE and Hpy/ori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS： The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls. The incidence of H pyiori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of Hpylori infection. CONCLUSION： No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pldori infection.

关键词： Diabetes mellitus reflux esophagitis Helicobacter pylori

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Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa

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World Journal of Gastroenterology 2009年第29期15卷 3621-3630页

作者： Fei-Yue Li Yan Li Department of Digestive Diseases Central Hospitalof Daqing Youtian Daqing 163000 Heilongjiang ProvinceChina Department of Digestive Diseases Shengjing Hospitalof China Medical University Shenyang 110004 LiaoningProvince China

AIM： To investigate the correlation between the expression levels of interleukin （IL）-6 and proteins in tight junctions （TJs） in the esophageal mucosa of rats modeling different types of reflux esophagitis （RE）, and the ability of aluminum phosphate to protect against RE-induced mucosal damage via these proteins. METHODS： Male SPF Wistar rats aged 56 d were divided randomly into acid RE, alkaline RE, mixed RE, and control groups. Various surgical procedures were performed to establish rat models of acid RE. At 14 d after the procedure, some of the rats started aluminum phosphate treatment. Transmission electron microscopy （TEM） was used to observe the morphological features of TJs and desmosomes in the esophageal epithelium. Immunohistochemical methods and Western blotting were used to measure expression of claudin 1, occludin, ZO-1, JAM-l, DSG-1 and IL-6; reverse transcription polymerase chain reaction （RT- PCR） was used to measure expression of mRNA of claudin 1, occludin, ZO-1, JAM-1, DSG-1 and IL-6. RESULTS： At day 14 alter the procedures, an RE model was established in all subsequently sacrificed rats of groups A, B and C. By both gross and microscopic observation, the mucosa was damaged and thickened as the disease progressed. With TEM observation, a widened intercellular space was noticed, with significantly fewer desmosomes. Immunohistochemistry showed significantly higher levels of all proteins in all RE models compared to control rats at 3 d after operation （65.5% ± 25.6% vs 20.5% ± 2.1%, P 〈 0.05, respectively）. At 14 d after operation, along with continuing hyperplasia in the basal layer, the expression of TJ proteins in individual cells gradually decreased （12.4% ± 2.1% vs 20.5% ± 2.1%, P 〈 0.05, respectively）. Western blottings and RT-PCR showed a directly proportional increase in IL-6 levels in relation to TJ proteins, as compared to controls （0.878 ± 0.024 vs 0.205 ± 0.021 and 0.898±0.022 vs 0.205 ± 0.021, P 〈 0.05, respectively）. Upon treatment with

关键词： reflux esophagitis Desmosome Tightjunction Proteins Mucosa

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Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

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World Journal of Gastroenterology 2009年第8期15卷 990-995页

作者： Ri-Nan Zheng Hainan Medical College 31 Longhua Road Haikou 57102 Hainan Proince China

AIM: To clarify whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four Proton pump inhibitors (PPIs). METHODS: Two hundred and seventy-four patients with erosive reflux esophagitis were randomized to receive 8 wk of 20 mg omeprazole (n = 68), 30 mg of lansoprazole (n = 69), 40 mg of pantoprazole (n = 69), 40 mg of esomeprazole (n = 68) once a day in the morning. Daily changes in heartburn and acid reflux symptoms in the first 7 d of administration were assessed using a six-point scale (0: none; 1: mild; 2: mild-moderate; 3: moderate; 4: moderate-severe; 5: severe). RESULTS: The mean heartburn score in patients treated with esomeprazole more rapidly decreased than those receiving other PPI. Complete resolution of heartburn was also more rapid in patients treated with esomeprazole for 5 d compared with omeprazole (P = 0.0018, P = 0.0098, P = 0.0027, P = 0.0137, P = 0.0069, respectively), lansoprazole (P = 0.0020, P = 0.0046, P = 0.0037, P = 0.0016, P = 0.0076, respectively), and pantoprazole (P = 0.0006, P = 0.0005, P = 0.0009, P = 0.0031, P = 0.0119, respectively). There were no significant differences between the four groups in the rate of endoscopic healing of reflux esophagitis at week 8. CONCLUSION: Esomeprazole may be more effective than omeprazole, lansoprazole, and pantoprazole for the rapid relief of heartburn symptoms and acid reflux symptoms in patients with reflux esophagitis.

关键词： Omeprazole Pantoprazole Lansoprazole Esomeprazole reflux esophagitis Symptom relief

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Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity

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World Journal of Gastroenterology 2009年第38期15卷 4799-4805页

作者： Sae-Kwang Ku Bu-Il Seo Ji-Ha Park Gyu-Yeol Park Young-Bae Seo Jae-Soo Kim Hyeung-Sik Lee Seong-Soo Roh Department of Histology and Anatomy College of Oriental MedicineDaegu Haany University Department of Herbology College of Oriental MedicineDaegu Haany University Department of Herbology College of Oriental MedicineDaejeon University Department of Acupuncture & Moxibustion College of Oriental MedicineDaegu Haany University Department of Clinical Laboratory Science College of Health and TherapyDaegu Haany University

AIM： To observe the effects of traditional antiinflammatory medicine Lonicerae FIos （LF） on rat reflux esophagitis （RE） induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, α-tocopherol. METHODS： Rats were pretreated with three different dosages of LF （500, 250 and 125 mg/kg） orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase （SOD）, catalase （CAT）, malondialdehyde （MDA）, myeloperoxidase and glutathione （GSH） levels, and collagen contents （marker of flexibility） were observed on the esophageal and fundic histopathology. The results were compared with an α-tocopherol （once orally, 1 h before operation, 30 mg/kg） treated group in which the effects on RE were already ***： Pylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects α-tocopherol. CONCLUSION： The results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease.

关键词： reflux esophagitis Tocopherol LoniceraeFlos Antioxidant Myeloperoxidase Pylorus and forestomach ligations

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