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From infections to autoimmunity:Diagnostic challenges in common variable immunodeficiency

World Journal of Clinical Cases 2020年第18期8卷 3942-3955页

作者： Ewa Więsik-Szewczyk Karina Jahnz-Różyk Department of Internal Medicine PulmonologyAllergy and Clinical ImmunologyCentral Clinical Hospital of the Ministry of National DefenseMilitary Institute of MedicineWarsaw 04-141Poland

Common variable immunodeficiency(CVID)is the most common clinically significant primary antibody deficiency diagnosed in *** early symptoms are not *** include common infections,mainly of the respiratory tract,caused by typical microorganisms,so cases can be missed in primary *** the majority of patients increased susceptibility to infections coexists with signs or symptoms of autoimmunity,inflammation or polyclonal lymphoproliferation,which can divert diagnosis from immune *** overall incidence of malignancy is increased in CVID and certain cancers are significantly more *** and gastric carcinoma are the most frequently reported malignancies in CVID,so a high index of suspicion is *** delay in CVID is seen *** main goal of this paper is to increase the awareness about CVID among health care *** aim to present features which can be helpful in CVID diagnosis in order to shorten the“latency”of proper management of CVID *** review clinical symptoms,complications and laboratory abnormalities of *** replacement therapy is regarded as the cornerstone of pharmacological *** modes of Ig application,mainly subcutaneously and via the hyaluronidase-facilitated subcutaneous route,help to adjust therapy to patients’needs and *** there remain unmet *** remains to be seen whether CVID complications can be avoided by earlier diagnosis,treatment and thorough monitoring in the context of increased risk of *** of patient tailored protocols depending on the clinical phenotype and risk factors might be more *** most important consideration is to diagnose suspected cases and stratify patients in a precise and timely *** is needed to define features predictive of unfavorable prognosis.

关键词： Primary antibody deficiency recurrent respiratory tract infections Complications Immunoglobulin replacement Adults Early diagnosis

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Association between gastrointestinal heat retention syndrome and respiratory tract infections in children:A prospective cohort study

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 216-223页

作者： Fei Dong He Yu Liqun Wu Tiegang Liu Xueyan Ma Jiaju Ma Xiaohong Gu School of Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Pediatric Department Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijing100078China Pneumology Department Beijing Hospital of Traditional Chinese MedicineBeijing100010China

Objective:To explore the relationship between gastrointestinal heat retention syndrome and the incidence of pneumonia and recurrent respiratory tract infections(RRTIs)in ***:A prospective cohort study was conducted in the pediatric outpatient department of Beijing Dongfang *** without respiratory tract infections(RTIs)were consecutively recruited according to the selection criteria.A semi-structured questionnaire was used to record traditional Chinese medicine(TCM)symptoms and demographic and physiological *** heat retention syndrome was considered to be a predisposing factor and was diagnosed according to a scale with reliability and *** participants were followed up for 12 *** and their parents or guardians were contacted via clinical interviews and telephone every 6 *** of pneumonia and RTIs were recorded in ***:A total of 420 children were *** participants,370(88.10%)were followed up for 12 *** mean number of RTI episodes per participant was 5.37(95%CI:5.14 to 5.60).In total,186 participants in the gastrointestinal heat retention syndrome group and 184 participants in the nongastrointestinal heat retention syndrome group completed the 12-month follow-up *** baseline of both groups was *** incidence of RRTIs in children with gastrointestinal heat retention syndrome was 1.27(95%CI:1.01 to 1.59)times that in children without gastrointestinal heat retention *** regression analysis revealed that abnormally increased appetite with frequent hunger,foul breath,dry stools,and dark red or purple fingerprints were positively correlated with the incidence of *** and feverish feelings in the palms and soles were positively correlated with the occurrence of ***:Gastrointestinal heat retention syndrome is a risk factor for RRTIs in *** with larger sample sizes and longer follow-up tim

关键词： Gastrointestinal heat retention syndrome Pneumonia recurrent respiratory tract infections Children Prospective cohort study

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