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Synthesis and radiation dosimetry of [68Ga]-Ga-Lys1, Lys3-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology

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Journal of Encapsulation and Adsorption Sciences 2020年第2期10卷 29-41页

作者： Juan C. Manrique-Arias Quetzali Pitalua-Cortes Roberto Pedrero-Piedras Géiser Rodríguez-Mena Tessy López Cristian Cabezas-Ortiz Osvaldo García-Pérez Departamento de Medicina Nuclear Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología México City México Cancer Center Cyclotron Department Doctors Hospital Monterrey México Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco México City México

This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys1, Lys3-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [68Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).

关键词： radiation dosimetry Biodistribution PET Imaging Radiopharmaceutical Lys1 Lys3-DOTA-BBN (1 14) Bombesin Analogs

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Synthesis and optical properties of novel Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics for radiation detection applications

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Journal of Rare Earths 2022年第12期40卷 1927-1934,I0005页

作者： Wanli Li Zhaoyang Chen Jie Xu Pengjun Zhao Yanwei Fan Chengfa He Key Laboratory of Functional Materials and Devices for Special Environments of CAS Xinjiang Key Laboratory of Electronic Information Materials and DevicesXinjiang Technical Institute of Physics&Chemistry of CASUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Laboratory of Solid-State radiation Physics Urumqi 830011China

45 P_(2)O_(5)-15 BaO-25 ZnO-15 B2O_(3)glasses doped with different concentrations(0 mol%,0.1 mol%,0.25 mol%,0.5 mol%,and 0.75 mol%)of Gd^(3+)were prepared by a melt-quenching method and treated to fabricate glass-ceramics containing BaZn_(2)(PO_(4))_(2)crystals by controllable *** structural,optical,and dosimetric properties were *** spectra indicate that the glasses are composed of[PO_(4)],[BO_(3)],and[BO_(4)]basic structural *** XRD pattern analysis indicates that the samples contain BaZn_(2)(PO_(4))_(2)*** the photoluminesce nce(PL)spectra,two emission bands are observed at 307 and 313 nm due to the^(6)P_(5/2)→^(8)S_(7/2)and^(6)P_(7/2)→^(8)S_(7/2)transitions of Gd^(3+),*** OSL dosimetric properties of glass-ceramics were studied further under beta radiation *** optimal Gd^(3+)doping concentration of 0.5 mol%was *** fading of the OSL signal shows that the CW-OSL signal of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics decays by about 58.95%within120 h,and the intensity remains stable *** thermoluminescence(TL)curve has three peaks at 164,240,and 344℃.Minimum detectable dose(MDD)of the 0.5 mol%Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics was calculated as 0.675 *** samples also exhibit good signal reusability and a broad linear dose-response range(0.3-500 Gy).Results show the excellent dosimetric properties of Gd^(3+)-doped BaZn_(2)(PO_(4))_(2)glass-ceramics and their potential application in radiation dosimetry.

关键词： Glass-ceramics Photoluminescence Continuous wave-optically stimulated luminescence Thermoluminescence radiation dosimetry Rare earths

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dosimetry and Shielding Method for Peri-apical Film and Panoramic Tomography

Dosimetry and Shielding Method for Peri-apical Film and Pano...

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中华口腔医学会第14次全国口腔医学学术会议（2012年...

作者： M.D Candidate:Guosong Han Department of Oral and Maxillofacial Radiology Peking University School and Hospital of Stomatology

Objectives *** evaluate the effective radiation dose of peri-apical film and digital panoramic radiography. *** evaluate the impact of thyroid collar on radiation dose reduction during periapical film and digital panoramic examinations. Methods *** of effective radiation dose①Thermoluminescent dosimeter(TLD)chips were positioned at each of 21 locations within the head and neck region of an ART-210 phantom.②The phantom was exposed with digital panoramic tomography and intraoral radigraphs,respectively.③Tissue-absorbed doses of TLD chips in all 21 locations were measured using a BR 2000D-ⅢA reader.④Effective organ dose and total effective dose were calculated. *** reduction by using thyroid collar①Measuring the effective radiation dose by the use of thyroid collar when periapical radiographs were exposed.②Measuring the effective radiation dose for panoramic tomography when one collar was used on the front neck of the phamtom and two collars were used both on the front and back neck of the phamtom.. Results *** effective dose of thyroid and total effective dose for full-mouth radiographs(14 peri-apical films)were 10.51μSv and 78.14μ*** panoramic tomography were 1.12μSv and 10.73μSv when OrthopantomographOP200 was *** Orthophos XG Plus was used the doses were 2.18μSv and 19.06μSv,respectively. *** thyroid collar was protective for full-mouth *** panoramic tomography taken with Orthopantomograph OP200 the thyroid collar was not *** Orthophos XG Plus,however,the collar was protective(pradiation reductio

关键词： radiation dosimetry Thyroid gland radiation Protection peri-apical film panoramic tomography

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