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riboflavin concentration in corneal stroma after intracameral injection

International Journal of Ophthalmology(English edition) 2015年第3期8卷 470-475页

作者： Na Li Xiu-Jun Peng Zheng-Jun Fan Xu Pang Yu Xia Teng-Fei Wu Chinese PLA Medical School & Chinese PLA General Hospital Department of Ophthalmology Navy General Hospital of Chinese PLA

AIM: To evaluate the enrichment of riboflavin in the corneal stroma after intracameral injection to research the barrier ability of the corneal endothelium to riboflavin in ***: The right eyes of 30 New Zealand white rabbits were divided into three groups. Different concentrations riboflavin-balanced salt solutions(BSS)were injected into the anterior chamber(10 with 0.5%, 10 with 1%, and 10 with 2%). Eight corneal buttons of 8.5mm in diameter from each group were dissected at 30 min after injection and the riboflavin concentrations in the corneal stroma were determined using high-performance liquid chromatography(HPLC) after removing the epithelium and endothelium. The other two rabbits in every group were observed for 24 h and sacrificed. As a comparison, the riboflavin concentrations from 16 corneal stromal samples were determined using HPLC after instillation of 0.1% riboflavin-BSS solution for30 min on the corneal surface(8 without epithelium and 8with intact epithelium).RESULTS: The mean riboflavin concentrations were11.19, 18.97, 25.08, 20.18, and 1.13 μg/g for 0.5%, 1%, 2%,de-epithelialzed samples, and the transepithelial groups,respectively. The color change of the corneal stroma and the HPLC results showed that enrichment with riboflavin similar to classical de-epithelialized corneal collagen crosslinking(CXL) could be achieved by intracameral 1%riboflavin-BSS solution after 30min; the effect appeared to be continuous for at least 30 ***: riboflavin can effectively penetrate the corneal stroma through the endothelium after an intracameral injection in vivo, so it could be an enhancing method that could improve the corneal riboflavin concentration in transepithelial CXL.

关键词： riboflavin cornea intracameral injection high-performance liquid chromatography endothelium

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Machine learning enabled prediction and process optimization of VFA production from riboflavin-mediated sludge fermentation

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Frontiers of Environmental Science & Engineering 2023年第11期17卷 181-193页

作者： Weishuai Li Jingang Huang Zhuoer Shi Wei Han Ting Lü Yuanyuan Lin Jianfang Meng Xiaobing Xu Pingzhi Hou College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China China-Austria Belt and Road Joint Laboratory on Artificial Intelligence and Advanced Manufacturing Hangzhou Dianzi UniversityHangzhou 310018China Zhejiang Province Environmental Engineering Co.Ltd. Hangzhou 310012China M-U-T Maschinen-Umwelttechnik-Transportanlagen GmbH Stockerau 2000Austria

riboflavin is a redox mediator that promotes volatile fatty acids(VFAs)production from waste activated sludge(WAS)and is a promising method for WAS ***,time-and labor-consuming experiments challenge obtaining optimal operating conditions for maximal VFA *** this study,three machine learning(ML)models were developed to predict the VFAs production from riboflavin-mediated WAS fermentation *** the three tested ML algorithms,eXtreme Gradient Boosting(XGBoost)presented the best prediction performance and excellent generalization ability,with the highest testing coefficient of determination(R^(2)of 0.93)and lowest root mean square error(RMSE of 0.070).Feature importance analysis and their interactions using the Shepley Additive Explanations(SHAP)method indicated that pH and soluble protein were the top two input features for the *** intrinsic correlations between input features and microbial communities corroborated this *** the optimized ML model,genetic algorithm(GA)and particle swarm optimization(PSO)solved the optimal solution of VFA output,predicting the maximum VFA output as 650 mg COD/g *** study provided a data-driven approach to predict and optimize VFA production from riboflavin-mediated WAS fermentation.

关键词： Machine learning Volatile fatty acids riboflavin Waste activated sludge eXtreme Gradient Boosting

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Effects of nicotinamide and riboflavin on the biodesulfurization activity of dibenzothiophene by Rhodococcus erythropolis USTB-03

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Journal of Environmental Sciences 2008年第5期20卷 613-618页

作者： YAN Hai SUN Xudong XU Qianqian MA Zhao XIAO Chengbin Ning Jun Department of Biological Science and Technology School of Applied Science University of Science and Technology Beijing Beijing 100083 China Research Center for Eco-environmental Science Chinese Academy of Sciences Beijing 100085 China

Rhodococcus erythropolis USTB-03 is a promising bacterial strain for the biodesulfurization of dibenzothiophene （DBT） via a sulfurspecific pathway in which DBT is converted to 2-hydroxybiphenyl （2HBP） as an end product. The effects of nicotinamide and riboflavin on the sulfur specific activity （SA） of DBT biodesulfurization by R. erythropolis USTB-03 were investigated. Both nicotinamide and riboflavin were found to enhance the expression of SA, which was not previously reported. When R. erythropolis USTB-03 was grown on a medium containing nicotinamide of 10.0 mmol or riboflavin of 50.0 μmol, SA was raised from 68.0 or so to more than 130 mmol 2HBP/（kg dry cells.h）. When R. erythropolis USTB-03 was grown in the presence of both nicotinamide of 5.0 mmol and riboflavin of 25.0 μmol, SA was further increased to 159.0 mmol 2HBP/（kg dry cells.h）. It is suggested that the biological synthesis of reduced form of flavin mononucleotide （FMNH2）, an essential coenzyme for the activities of biodesulfurization enzyme Dsz C and A, might be enhanced by nicotinamide and riboflavin, which was responsible for the increased SA of R. erythropolis USTB-03.

关键词： biodesulfurization dibenzothiophene nicotinamide Rhodococcus erythropolis USTB-03 riboflavin

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Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy

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Chinese Chemical Letters 2022年第9期33卷 4339-4344页

作者： Chunlei Wu Yanyan Li Zhehong Cheng Pengxin Wang Zhilong Ma Ke Liu Yulian Cheng Yimin Zhou Xian Lin Ximing Shao Yong Yang Hongchang Li Lijing Fang Guangdong Key Laboratory of Nanomedicine Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Biomedical Engineering Southern University of Science and Technology(SUSTech)Shenzhen 518055China

riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural photosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by its poor cellular *** this study,using cell-penetrating peptides Arg8,(Cha-Arg)3 and small molecule triphenylphosphine(TPP)as delivery compounds,three RF conjugates were prepared to increase the accumulation of RF in cells,termed as Arg8-RF,(Cha-Arg)3-RF and TPP-RF,*** with TPP-RF and Arg8-RF,(Cha-Arg)3-RF exhibited better cell internalization and stronger cytotoxicity against HeLa cells upon exposure to blue *** researches proved that(Cha-Arg)3-RF generated reactive oxygen species(ROS)under irradiation,which could indiscriminately destroy endogenous proteins and mitochondria,ultimately inducing cell *** work provides a new approach to explore RF as a natural photosensitizer for antitumor photodynamic therapy.

关键词： riboflavin Antitumor Photodynamic therapy Cell-penetrating peptides

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Synthesis of highly fluorescent carbon dots from lemon and onion juices for determination of riboflavin in multivitamin/mineral supplements

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Journal of Pharmaceutical Analysis 2019年第3期9卷 209-216页

作者： Severino S. Monte-Filho Stefani I.E. Andrade Marcelo B. Lima Mario C.U. Araujo Universidade Federal da Paraíba CCEN Departamento de Química P.O. Box 5093 Zip Code 58051-970 Joao Pessoa PB Brazil Universidade Federal Rural de Pernambuco-Unidade Acad^emica de Serra Talhada UAST Zip Code 56909-535 Serra Talhada PE Brazil

In this work, lemon and onion biomasses commonly found in street markets are for the first time used to develop a facile, fast and low-cost one-step microwave-assisted carbonization method for synthesis of highly fluorescent carbon dots (CDs). The structure and optical properties of CDs were investigated by TEM, XRD, XRF, UV-Vis, FTIR, and fluorescence spectroscopy. CDs displayed satisfactory optical pro-prieties, a high quantum yield of 23.6%, and excellent water solubility, and the particle size was 4.23-8.22 nm with an average diameter of 6.15 nm. An efficient fluorescent resonance energy transfer (FRET) between the CDs and riboflavin was achieved with CDs acting as donor and riboflavin as acceptor. A linear relationship between FRET and the riboflavin concentration from 0.10 to 3.0 μg/mL was observed, allowing the development of an accurate and fast analytical method to determine this vitamin in multivitamin/mineral supplements. Despite the potential interferences in these supplements, CDs were selective for riboflavin under optimized conditions. A paired t-test at a 95% confidence level indicated no statistically significant difference between the proposed and the reference methods. Recovery test presented values ranged from 96.0% to 101.4%. The limit of detection and relative standard deviation were estimated at 1.0 ng/mL and riboflavin.

关键词： Carbon dots Microwave-assisted carbonization Lemon-onion juice riboflavin Multivitamin/mineral supplements Fluorescence

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Effect of riboflavin deficiency on intestinal morphology,jejunum mucosa proteomics,and cecal microbiota of Pekin ducks

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Animal Nutrition 2023年第1期12卷 215-226页

作者： Yaxi Xu Bo Zhang Rui Zhao Kexin Gao Suyun Liang Yongbao Wu Yongsheng Hao Dapeng Liu Zhanbao Guo Jian Hu Zhengkui Zhou Ming Xie Jing Tang State Key Laboratory of Animal Nutrition Key Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

This study was to determine the effects of riboflavin deficiency(RD)on intestinal development,jejunum mucosa proteome,cecal short-chain fatty acids(SCFA)profiling,and cecal microbial diversity and community of starter Pekin *** white Pekin ducks(1 d old,n=240)were allocated into 2 groups,with 12 replicates and 10 birds per replicate in each *** 21 d,all ducks had ad libitum access to either an RD or a riboflavin adequate(control,CON)diet,formulated by supplementing a basal diet with 0 or 10 mg riboflavin per kg of diet,*** to the CON group,growth retardation,high mortality,and poor riboflavin status were observed in the RD ***,RD reduced the villus height and the ratio of villus height to crypt depth of jejunum and ileum(P<0.05),indicating morphological alterations of the small *** addition,dietary RD enhanced relative cecum weight and decreased cecal SCFA concentrations(P<0.05),including propionate,isobutyrate,butyrate,and *** jejunum mucosa proteomics showed that 208 proteins were upregulated and 229 proteins were downregulated in the RD group compared to those in the CON *** these,RD mainly suppressed intestinal absorption and energy generation processes such as glycolysis and gluconeogenesis,fatty acid beta oxidation,tricarboxylic acid cycle,and oxidative phosphorylation,leading to impaired ATP *** addition,RD decreased the community richness and diversity of the bacterial community in the cecum of ***,RD reduced the abundance of butyrate-producing bacteria in the cecum(P<0.05),such as Eubacterium coprostanoligenes,Prevotella and *** RD resulted in growth depression and intestinal hypofunction of Pekin ducks,which could be associated with impaired intestinal absorption and energy generation processes in intestinal mucosa,as well as gut microbiota *** findings contribute to our understanding of the mechanisms of intestinal hypofuncti

关键词： riboflavin Deficiency Intestinal morphology Proteomics Cecal microbiota Short-chain fatty acids

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riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitis

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Annals of Eye Science 2019年第1期4卷 23-28页

作者： Choul Yong Park Roy S.Chuck Department of Ophthalmology Dongguk UniversityIlsan HospitalGoyangSouth Korea Department of Ophthalmology and Visual Sciences Montefiore Medical CenterAlbert Einstein College of MedicineBronxNYUSA

In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were *** written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(***/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen *** conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still *** is necessary to conduct a prospective case-control study for clear guidance for clinicians.

关键词： Acanthamoeba keratitis collagen ultraviolet A(UVA) riboflavin cross-linking

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Sociodemographic Factors Associated with Dietary Intake of Thiamine, riboflavin, and Niacin among Chinese Adults in 2015

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Biomedical and Environmental Sciences 2020年第9期33卷 660-669页

作者： LI Li ZHANG Bing WANG HuiJun OUYANG Yi Fei HUANG Fei Fei WANG Yun ZHANG Ji Guo SU Chang DU Wen Wen JIA Xiao Fang JIANG Hong Ru WANG Zhi Hong National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective To estimate the association between three B-vitamin intakes and sociodemographic factors among adults in *** We derived our data from the China Health and Nutrition Survey(CHNS) among 12,241 individuals aged 18–64 years. Log binomial regression was used to estimate adjusted prevalence ratios for factors associated with the inadequate intake of *** Females with low incomes and living in the north had a higher prevalence of inadequate riboflavin intake than those with high incomes and living in the south. Both males and females living in a village had a higher prevalence of inadequate riboflavin intake than adults living in a city. Adults with low income, low education, and living in the north or in a village had a higher prevalence of inadequate niacin intake than adults with a high income, high education, and living in the south or in a *** We found that income, region, and area of residence were associated with riboflavin intake. Education, income, region, and area of residence were associated with niacin intake. Welltailored strategies and policies are needed to improve nutritional status in China.

关键词： Thiamine riboflavin Niacin Vitamin B deficiency Nutritional requirements China

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SDS-PAGE study on photooxidation damage of lysozyme induced by riboflavin

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Science China Chemistry 2007年第1期50卷 84-90页

作者： ZHANG ZhaoXia ZHAO HongWei ZHU HongPing GE Min WANG WenFeng YAO SiDe LI WenXin Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Graduate University of Chinese Academy of Sciences Beijing 100049China

The photooxidation damage of lysozyme under 315-375 nm irradiation in the presence of riboflavin was studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Indica- tions showed that the mechanisms and products of oxidative damage were relative to the concentra- tion of riboflavin,the time of irradiation and the *** type I process was examined in a nitrogen saturated solution,whereas both type I and type II were observed in an aerobic atmosphere and type II was the dominant *** study also suggested that antioxidants,such as melatonin, can reduce the damage of lysozyme effectively.

关键词： lysozyme riboflavin photooxidation SDS-PAGE antioxidant

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Photosensitized damage to telomere overhang and telomerase RNA by riboflavin

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Progress in Natural Science:Materials International 2008年第4期18卷 401-404页

作者： Yuxia Liu, Fuqiang Du, Weizhen Lin , Tiecheng Tu, Wenxin Li, Nianyun Lin Key Laboratory of Nuclear Analysis Techniques, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Key Laboratory of Nuclear Analysis Techniques Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

By ESR spin elimination and photocleavage assay, the mechanisms of one-electron oxidation damage of oligonucleotides by excited triplet state of riboflavin (Rb) have been elucidated. The results demonstrate that Rb, an endogenous photosensitizer, is capable of cleav- ing single-stranded telomeric overhang and the template region of telomerase RNA under UVA irradiation, resulting in blocking of reverse transcription of telomeric DNA which leads to the apoptosis of cancer cells ultimately.

关键词： Telomere Telomerase riboflavin ESR spin elimination Excited triplet state

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