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Serum Gamma-glutamyl Transferase Concentration Within the reference range is Related to the Coronary Heart Disease Risk Prediction in Korean Men： Analysis of the Korea National Health and Nutrition Examination Survey （V-1, 2010 and V-2, 2011）

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Chinese Medical Journal 2015年第15期128卷 2006-2011页

作者： Kyung-Sun Han Doo-Yeoun Cho Young-Sang Kim Kyu-Nam Kim Department of Family Practice and Community Health Ajou University School of Medicine 164 Worldcup-Ro Youngtong-Gu Suwon Gyeonggi-Do Republic of Korea Department of Family Medicine Cha University Cha Bundang Medical Center Seongnam Gyeonggi-Do Republic of Korea

Background：Limited data exist on the association of serum gamma-glutamyl transferase （GGT） level within the reference range with the increased risk of coronary heart disease （CHD） prediction in *** study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean ***：The study employed data from Korean National Health and Nutrition Examination Survey （V-1,2010 and V-2,2011） where a total of 1301 individuals were analyzed.A 10-year CHD risk prediction was computed using the Framingham Risk Score （FRS） modified by the National Cholesterol Education Program （NCEP） Adult Treatment Panel Ⅲ （ATP Ⅲ）.Results：Positive correlations were established between log-transformed GGT concentration and FRS （r =0.237,P 〈 0.001）.After adjustment of body mass index,the amount of alcohol intake and low-density lipoprotein-cholesterol,the odds ratio （95% confidence interval） for intermediate risk and beyond of 10-year CHD prediction （10-year risk ≥10%） with lowest quartile of participants was 1.21 （0.78-1.87） for second quartiles,1.39 （0.88-2.21） for third quartiles and 2.03 （1.23-3.34） for highest ***：Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP Ⅲ in Korean men.

关键词： Framingham Risk Score Gamma-glutamyl Transferase reference range

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Alanine aminotransferase predicts incident steatotic liver disease of metabolic etiology: Long life to the old biomarker!

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World Journal of Gastroenterology 2024年第24期30卷 3016-3021页

作者： Amedeo Lonardo Department of Internal Medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Alanine aminotransferase(ALT)serum levels increase because of hepatocellular *** dysfunction-associated fatty liver disease(MAFLD),which identifies steatotic liver disease(SLD)associated with≥2 metabolic abnormalities,has prominent sexual *** Metabolic Syndrome defines a cluster comprising abdominal obesity,altered glucose metabolism,dyslipidemia,and *** sex,body mass index,glucose,lipids,ferritin,hypertension,and age independently predict ALT levels among blood *** the last few decades,the reference range of ALT levels has been animatedly debated owing to attempts to update sex-specific reference *** this backset,Chen et al have recently published a study which has two main ***,>80%of indi-viduals with MAFLD had normal ALT ***,there was a linear increa-sing trend in the association between cumulative excess high-normal ALT levels and the rate of incident *** study has biologically credible ***,it inaccurately considered sex differences in the MAFLD ***,future studies on SLD owing to metabolic dysfunction should adopt locally determined and prospectively validated reference ranges of ALT and carefully consider sex differences in liver enzymes and MAFLD pathobiology.

关键词： Alanine aminotransferase Biomarker History of medicine Metabolic dysfunction-associated fatty liver disease Metabolism Nonalcoholic fatty liver disease reference range Sex differences Steatotic liver disease

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Comparison of reference values for immune recovery between event-free patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor allografts

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Frontiers of Medicine 2018年第2期12卷 153-163页

作者： Xuying Pei Xiangyu Zhao Yu Wang Lanping Xu Xiaohui Zhang Kaiyan Liu Yingjun Chang Xiaojtm Huang Peking University People's Hospital & Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem CellTransplantation Beijing 100044 China Peking-Tsinghua Center for Life Sciences Beijing 100044 China

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution （IR） in 144 patients who received allogeneic stem ceil transplantation （alio- SCT） and without showing any of the following events： poor graft function, grades II-IV acute graft-versus-host disease （GVHD）, serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3~ T cells, CD8~ T cells, and CD19~ B cells, and very slow in CD4~ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune ceils need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune ceil counts in patients receiving HSCT.

关键词： immune reconstitution hematopoietic stem cell transplantation event-free patients reference range

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New formula for predicting standard liver volume in Chinese adults

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World Journal of Gastroenterology 2017年第27期23卷 4968-4977页

作者： Ling-Mei Feng Pei-Qin Wang Hong Yu Ru-Tan Chen Jian Wang Xia Sheng Zong-Li Yuan Pei-Mei Shi Wei-Fen Xie Xin Zeng Department of Gastroenterology Shanghai Changzheng HospitalSecond Military Medical University Department of Radiology Shanghai Changzheng HospitalSecond Military Medical University

AIM To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume(SLV) in Chinese *** Computed tomography(CT)-estimated total liver volume(CTLV) was determined in 369 Chinese adults. Age,sex,body weight,body height,body mass index,and body surface area(BSA) were recorded using CT. Total splenic volume,portal venous diameter(PVD),splenic venous diameter(SVD),and portal venous cross-sectional area(PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation *** The average CTLV was 1205.41 ± 257.53 cm3(range,593.80-2250.10 cm3). The average of PVD,SVD and PVCSA was 9.34 ± 1.51 mm,7.40 ± 1.31 mm and 173.22 ± 48.11 mm2,respectively. The CT-estimated splenic volume of healthy adults varied markedly(range,46.60-2892.30 cm3). Sex,age,body height,body weight,body mass index,and BSA were significantly correlated with CTLV. BSA showed the strongest correlation(r = 0.546,P 70 years of age,and underestimated liver volume when CTLV was > 1800 *** Our new BSA-based formula is more accurate than other formulas in estimating SLV in Chinese adults.

关键词： Standard liver volume reference range Morphological indices Chinese adults

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Falling sperm counts and global estrogenic pollution： what have we learned over 20 years？

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Asian Journal of Andrology 2013年第2期15卷 159-161页

作者： David J Handelsman Trevor G Cooper ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia Tuen Mun NT Hong Kong SAR PR ChinaGuest Editors for this special issue: Prof. DJ Handelsman

If scandal is the engine of progress in politics, and sensation is that of the media, while anti-modern panic is that of environmentalism, what is the dynamic of medical science？ Certainly discovery and invention represent the admirable high road, whereas competition and controversy represent the quotidian low road. This Special Issue is directed to reviewing the lessons learned from the most public, fervent and durable controversy in the short history of Andrology, the claims of world-wide falling sperm counts, due to global pollution by industrial estrogenic chemicals, published two decades ago.

关键词： EXTERNAL QUALITY-CONTROL SEMEN ANALYSIS reference range IN-UTERO BIAS MEN ASSOCIATION GUIDELINES FERTILITY

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Analysis of results related to the percent free prostate specific antigen among men without prostate diseases in Xi'an area

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Journal of Nanjing Medical University 2007年第1期21卷 25-28页

作者： Peng Zhang Ziming Wang Tie Chong Lihua Zhao Department of Urology the Second Affiliated Hospital of Medical College of Xi＇an JiaoTong University Xi＇ an 710004 China Department of clinical laboratory the Second Affiliated Hospital of Medical College of Xi＇ an JiaoTong University Xi＇ an 710004China

To measure the percent of free prostate specific antigen （fPSA） among men without prostate diseases in Xi＇an area, and to study the relationship of percent fPSA with age and pathological grade, clinical stage of prostate cancer （PCa） with percent fPSA, and to analyze the difference between the data in China and *** data to determine appropriate reference range for Chinese male. Methods： A total of 713 participants were enrolled into the study, with PSA, fPSA in serum measured and the percent fPSA calculated. Out of 713 cases, 679 without prostate diseases were divided into 5 groups by age, and then the relationships of PSA, fPSA and percent fPSA with age were studied, respectively. The relationship of pathological grade and clinical stage with percent fPSA of the 34 participants with PCa was also studied. With the help of the related data of men without prostate disease, the appropriate reference range for Chinese male was established. Results： The increases in PSA or fPSA were correlated with age, while there was no significant correlation between age and percent fPSA. The percent fPSA was also correlated with pathological grade and clinical stage of PCa. The percent fPSA of men without prostate disease in Xi＇an area was significandy lower than that in the related overseas data. The reference range of percent fPSA for Chinese male was≥ 15%. Conclusion： Percent fPSA might be more useful than PSA in the detection of prostate cancer. As the percent fPSA is decreased, the pathological grade is decreased, and the clinical stage is increased, the malignant degree is increased. The reference range of ≥15% is more appropriate for Chinese male.

关键词： percentage free prostate specific antigen prostate cancer Age relativity reference range Xi'an area

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