Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men： Analysis of the Korea National Health and Nutrition Examination Survey （V-1, 2010 and V-2, 2011）

作     者：Kyung-Sun Han Doo-Yeoun Cho Young-Sang Kim Kyu-Nam Kim 

作者机构：Department of Family Practice and Community Health Ajou University School of Medicine 164 Worldcup-Ro Youngtong-Gu Suwon Gyeonggi-Do Republic of Korea Department of Family Medicine Cha University Cha Bundang Medical Center Seongnam Gyeonggi-Do Republic of Korea 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第15期

页      面：2006-2011页

核心收录：

学科分类：0710[理学-生物学] 120202[管理学-企业管理（含：财务管理、市场营销、人力资源管理）] 12[管理学] 071010[理学-生物化学与分子生物学] 1202[管理学-工商管理] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：Framingham Risk Score Gamma-glutamyl Transferase Reference Range 

摘      要：Background：Limited data exist on the association of serum gamma-glutamyl transferase （GGT） level within the reference range with the increased risk of coronary heart disease （CHD） prediction in *** study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean ***：The study employed data from Korean National Health and Nutrition Examination Survey （V-1,2010 and V-2,2011） where a total of 1301 individuals were analyzed.A 10-year CHD risk prediction was computed using the Framingham Risk Score （FRS） modified by the National Cholesterol Education Program （NCEP） Adult Treatment Panel Ⅲ （ATP Ⅲ）.Results：Positive correlations were established between log-transformed GGT concentration and FRS （r =0.237,P 〈 0.001）.After adjustment of body mass index,the amount of alcohol intake and low-density lipoprotein-cholesterol,the odds ratio （95% confidence interval） for intermediate risk and beyond of 10-year CHD prediction （10-year risk ≥10%） with lowest quartile of participants was 1.21 （0.78-1.87） for second quartiles,1.39 （0.88-2.21） for third quartiles and 2.03 （1.23-3.34） for highest ***：Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP Ⅲ in Korean men.