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Tumor Necrosis Factor-alpha Induced Protein 3 Interacting Protein I Gene Polymorphisms and pustular psoriasis in Chinese Han Population

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Chinese Medical Journal 2016年第13期129卷 1519-1524页

作者： Jian-Wen Han Yong Wang Chulu Alateng Hong-Bin Li Yun-Hua Bai Xin-Xiang Lyu Rina Wu Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Rheumatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Hulunbeier People's Hospital Hulunbeier Inner Mongolia 021000 China

Background： psoriasis is a common immune-mediated inflammatory dermatosis. Generalized pustular psoriasis （GPP） is the severe and rare type of psoriasis. The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 （TNIP1） gene and psoriasis was confirmed in people with multiple ethnicities. This study was to investigate the association between TNIP1 gene polymorphisms and pustular psoriasis in Chinese Hart population. Methods： Seventy-three patients with GPP, 67 patients with palmoplantar pustulosis （PPP）, and 476 healthy controls were collected from Chinese Hart population. Six single nucleotide polymorphisms （SNPs） of the TNIP1 gene, namely rs3805435, rs3792798, rs3792797, rs869976, rs 17728338, and rs999011 were genotyped by using polymerase chain reaction-ligase detection reaction. Statistical analyses were performed using the PLINK 1.07 package. Allele frequencies and genotyping frequencies for six SNPs were compared by using Chi-square test, odd ratio （OR）（including 95% confidence interval） were calculated. The haplotype analysis was conducted by Haploview software. Results： The frequencies of alleles of five SNPs were significantly different between the GPP group and the control group （P ≤ 7.22 × 10^-3）, especially in the GPP patients without psoriasis vulgaris （PsV）. In the haplotype analysis, the most significantly different haplotype was H4： ACGAAC, with 13.1% frequency in the GPP group but only 3.4% in the control group （OR = 4.16, P = 4.459 × 10^-7）. However, no significant difference in the allele frequencies was found between the PPP group and control group for each of the six SNPs （P 〉 0.05）. Conclusions： Polymorphisms in TNIP1 are associated with GPP in Chinese Han population. However, no association with PPP was found. These findings suggest that TNIPI might be a susceptibility gene for GPE

关键词： Association pustular psoriasis Single Nucleotide Polymorphism Tumor Necrosis Factor-alpha Induced Protein 3Interacting Protein 1

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“Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis

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Cellular & Molecular Immunology 2021年第2期18卷 307-317页

作者： Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson Graduate Program in Immunology University of MichiganAnn ArborMIUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Dermatology University of CaliforniaDavisSacramentoCAUSA Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMIUSA A.Alfred Taubman Medical Research Institute Ann ArborMIUSA Departments of Nutrition and Dermatology Case Western Reserve UniversityClevelandOHUSA

psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical *** psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune *** recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis *** this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular *** further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis.

关键词： pustular psoriasis Genetics IL-36 Autoinflammation Clinical features Histology

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Recalcitrant paradoxical pustular psoriasis induced by infliximab:Two case reports

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World Journal of Clinical Cases 2021年第15期9卷 3655-3661页

作者： Ping Xia Yan-Hong Li Zhong Liu Xu Zhang Qian Jiang Xiao-Yong Zhou Wei Su Department of Dermatology The First Hospital of WuhanWuhan 430022Hubei ProvinceChina Department of Dermatology Midwest Center for Dermatology and Cosmetic SurgeryClinton TownshipMI 48038United States

BACKGROUND Paradoxical psoriasis induced by tumor necrosis factor alpha antagonists is a rare side effect of those drugs and has similarities with and differences from classical psoriasis in clinical and pathological *** severe paradoxical psoriasis is challenging because the reported cases are rare,with treatment experience being only *** SUMMARY We report 2 cases of paradoxical psoriasis caused by *** cases manifested with a significant number of pustular lesions and had protracted and complicated clinical *** case 1,secukinumab alone could not control the eruptions,but colchicine supplementation markedly decreased disease *** case 2 miscellaneous medications were administered,including the systemic drug acitretin,the immunosuppressive drug cyclosporine,and the biologic agent ***,multiple applications of those medications failed to prevent new lesions from *** cases showed moderate-to-high antinuclear antibody *** Based on these cases,moderate-to-high anti-nuclear antibody titer seems to be a risk factor for paradoxical *** addition,extensive pustular presentation may be a negative prognostic indicator and may portend a protracted clinical course refractory to therapy.

关键词： pustular psoriasis Paradoxical Infliximab Secukinumab Ustekinumab Antinuclear antibody Case report

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