“Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis

作     者：Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson 

作者机构：Graduate Program in ImmunologyUniversity of MichiganAnn ArborMIUSA Department of DermatologyUniversity of MichiganAnn ArborMIUSA Department of PathologyUniversity of MichiganAnn ArborMIUSA Department of DermatologyUniversity of CaliforniaDavisSacramentoCAUSA Division of RheumatologyDepartment of Internal MedicineUniversity of MichiganAnn ArborMIUSA A.Alfred Taubman Medical Research InstituteAnn ArborMIUSA Departments of Nutrition and DermatologyCase Western Reserve UniversityClevelandOHUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第2期

页      面：307-317页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：This work was supported by the Babcock Endowment Fund(L.C.T.and J.E.G.) the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award numbers R01-AR060802(J.E.G.) P30-AR075043(J.E.G.) and K01-AR072129(L.C.T.) and the National Institute of Allergy and Infectious Diseases under award number R01-AR069071(J.E.G.) the A.Alfred Taubman Medical Research Institute(J.E.G.and J.M.K.) the National Psoriasis Foundation(J.E.G N.L.W. J.M.K. E.M. and L.C.T.) and the Parfait Emerging Scholar Award(J.M.K.).L.C.T.is supported by the Dermatology Foundation the Arthritis National Research Foundation and the National Psoriasis Foundation 

主　　题：Pustular psoriasis Genetics IL-36 Autoinflammation Clinical features Histology 

摘      要：Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical *** psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune *** recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis *** this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular *** further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis.