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Relationship between Neutrophil-to-Lymphocyte Ratio and pulse wave velocity in Young Patients with Systemic Lupus Erythematosus

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Chinese Medical Journal 2018年第1期131卷 10-15页

作者： Xu-Fei Yang Fa-Ming Ding Yi-Cong Ye Shu-Yang Zhang Department of Cardiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China

Background： The incidence of atherosclerosis-related myocardial infarction can be as much as 50-fold greater in young patients with systemic lupus e~,thematosus （SLE） than in age-matched controls. There are several explanations for this phenomenon, all of which result in a chronic state of low-grade inflammation. Recently, the neutrophil-to-lynlphocyte ratio （NLR） has been proposed as a useliil biomarker of inflammation. pulse wave velocity （PWV） is a reliable indicator of vascular damage and atherosclerosis. There is a paucity of data concerning the relationship between NLR and atherosclerosis as measured by PWV in patients with SLE. This study aimed to verify whether there is a positive correlation between NLR and PWV and to explore factors that influence PWV in young SLE patients. Methods： A total of 90 female patients with SLE were enrolled in this cross-sectional investigation. Traditional and nontraditional cardiovascular risk factors were assessed on the same day that brachial-ankle PWV （baPWV） was examined. The patients were divided into three groups according to their mean baPWV values： patients whose mean baPWV value was lower than the first tertile were placed in Group 1 ： patients whose mean baPWV value was between the first tertile and the second tertile were placed in Group 2： and patients whose mean baPWV value was higher than the second tertile were placed in Group 3. SPSS 20.0 was used to perform all statistical analyses in this study. Both univariate linear regression and multivariate regression models were utilized to analyze the association between NLR and arterial stiffness. Results： Systolic blood pressure, diastolic blood presstire （DBP）. and triglycerides were all significantly different among Groups 1,2, and 3 （ 111.90 ± 12.85 mmHg vs. 114.60 ± 12.88 mmHg vs. 129.43 ±16.21 mmHg, P 〈 0.001 ： 68.77 ± 8.63 mmHg vs. 71.87 ± 9.77 mmHg vs. 82.57 ± 14.89 mmHg, P 〈 0.001 ; and 1.44 [0.91-2.47] mmol/L vs. 0.98 [0.78-1.26] mmol/L vs. 2.20 [0.94-3.66]

关键词： Arterial Stiffness: Neutrophil-to-Lymphocyte Ratio pulse wave velocity Systemic Lupus Erythematosus

Relationship of plasma level of Lp-PLA_2 and pulse wave velocity and carotid intima-media thickness

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South China Journal of Cardiology 2014年第4期15卷 261-266页

作者： LUO Ying WANG Li-li LONG Juan CHEN Qi-ying HU Wei Cardiovascular Department of Sun Yat-sen Cardiovascular Hospital

Background Increased plasma level of Lp-PLA2 is a potential risk factor for atherosclerosis. Nevertheless, whether Lp-PLA2 has effects on both vascular function and structure changes is still unclear. Method One hundred and eighty-six outpatient subjects without overt cardiovascular disease were enrolled and anthropomet- ric data, plasma level of Lp-PLA2 and other related laboratory parameters were collected. Measurements of pulse wave velocity （PWV） and carotid intima-media thickness （CIMT） were performed by an experienced investigator. According to plasma level of Lp-PLA2, all the subjects were divided into two groups as follows：〈 200 ng/mL （n = 96） and ≥200 ng/mL （n = 90）. Result Body mass index, smoking, diabetic mellitus, systolic blood pressure, and LDL-C level were positive correlation with plasma level of Lp-PLA2, while use of statins was negatively correlative. Both PWV and CIMT positively correlated with smoking, systolic blood pressure, LDL-C level and plasma level of Lp-PLA2, while negatively correlated with HDL-C level and usage of statins. CIMT in the group with plasma level of Lp-PLA2 〈 200 ng/mL （0.9 ± 0.2 mm, n = 96） was sig- nificantly less than that with plasma level of Lp-PLA2≥200 ng/mL （1.2 ±0.4 mm, n = 90, P = 0.32）, and similar finding was also observed in PWV （9.1± 0.5 m/s vs 12.7 ± 0.4 m/s, P = 0.38）. Conclusion Our present study shows that in subjects without overt CVD, increased plasma level of Lp-PLA2 is associated with vascular function （PWV） and structure （CIMT） deterioration.

关键词： lipoprotein-associated phospholipase A2 carotid intima-media thickness pulse wave velocity

The value of pulse wave velocity in the diagnosis of coronary heart disease

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Journal of Medical Colleges of PLA(China) 2006年第4期21卷 254-257页

作者：贾新未刘铭雅魏盟陆志刚 Cardiac Department Affiliated Hospital of Hebei UniversityBaoding 071000China Cardiac Department Shanghai Sixth People's HospitalShanghai 200233China

Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.

关键词： coronary heart disease coronary angiography pulse wave velocity receiver operating characteristic diagnosis

Altered heart rate variability and pulse-wave velocity after spinal cord injury

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World Journal of Clinical Cases 2022年第27期10卷 9680-9692页

作者： Hsi-Kai Tsou Kuan-Chung Shih Yueh-Chiang Lin Yi-Ming Li Hsiao-Yu Chen Functional Neurosurgery Division Neurological InstituteTaichung Veterans General HospitalTaichung 404Taiwan Department of Rehabilitation Jen-Teh Junior College of MedicineNursing and ManagementMiaoli County 356Taiwan College of Health National Taichung University of Science and TechnologyTaichung 403Taiwan College of Medicine National Chung Hsing UniversityTaichung 402Taiwan Research Assistant The Rong Sing Medical FoundationTaichung 404Taiwan Research Assistant Neurological InstituteTaichung Veterans General HospitalTaichung 404Taiwan Research Assistant Department of NursingNational Taichung University of Science and TechnologyTaichung 403Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and TechnologyTaipei 106Taiwan Department of Nursing National Taichung University of Science and TechnologyTaichung 403Taiwan

BACKGROUND Heart rate variability(HRV) and pulse-wave velocity(PWV),indicators of cardiac function,are altered in patients with spinal cord injury(SCI),suggesting that autonomic cardiac function and arterial stiffness may underlie the high risk of cardiovascular complications in these *** study has simultaneously investigated HRV and PWV in the same *** To evaluate cardiovascular complications in SCI patients by comparing HRV and PWV between patients with and without *** In this cross-sectional pilot study,patients with(n = 60) and without SCI(n = 60) were recruited from December 7,2019 to January 21,*** participant received a five-minute assessment of HRV and the cardiovascular system using the Medicore HRV Analyzer SA-3000 *** in HRV and PWV parameters between participants with and without SCI were statistically *** We observed a significant difference between participants with and without SCI with respect to the standard deviation of all normal-to-normal intervals,square root of the mean sum of squared successive risk ratio interval differences,physical stress index,total power,very-low frequency,low frequency,high frequency,and arterial *** Patients with SCI have weaker sympathetic and parasympathetic activity as well as lower arterial elasticity compared to those without,suggesting that SCI may increase cardiac function loading.

关键词： Acceleration plethysmography Cardiac function Heart rate variability pulse wave velocity Spinal cord injury

Correlations between ultrasonic pulse wave velocities and rock properties of quartz-mica schist

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第3期10卷 594-602页

作者： Bharti Chawre Central Soil and Materials Research Station New Delhi110016India

Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist（QMS） rocks in a cost-effective manner by establishing correlations between non-destructive and destructive tests. Using simple regression analysis, good correlations were obtained between the pulse wave velocities and the properties of QMS rocks. The results were further improved by using multiple regression analysis as compared to those obtained by the simple linear regression analysis. The results were also compared to the ones obtained by other empirical equations available. The general equations encompassing all types of rocks did not give reliable results of rock properties and showed large relative errors, ranging from 23% to 1146%. It is suggested that empirical correlations must be investigated separately for different types of rocks. The general empirical equations should not be used for the design and planning purposes before they are verified at least on one rock sample from the project site, as they may contain large unacceptable errors.

关键词： pulse wave velocity Physico-mechanical properties Quartz-mica schist (QMS) rocks Non-destructive methods Static elastic constants Dynamic elastic constants

Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function

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Journal of Geriatric Cardiology 2012年第2期9卷 158-165页

作者： Su-Yan Bian Hong-Yang Guo Ping Ye Lei-Ming Luo Hong-Mei Wu Wen-Kai Xiao Li-PingQi He-Peng Yu Liu-Fa Duan The Second Department of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Departmen of Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective Both decreased glomemlar filtration rate （GFR） and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. Methods In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR 〉 60 mL/min per 1.73 m2 estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity （PWVcf） and carotid-radial PWV （PWVcr） using a validated automatic device. Augmentation Index at heart rate 75 beats/minutes （AIx-75） was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. Results The mean estimated GFR （eGFR） of the study group was 100.05 ＋ 23.26 mL/minute per 1.73 m2. Subjects were grouped by tertiles of eGFR level. PWVef and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AJx-75. Conclusions In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population.

关键词： Arterial stiffness Augmentation index pulse wave velocity Glomerular filtration rate Chinese women

Association between serum homocysteine and arterial stiffness in elderly： a community-based study

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Journal of Geriatric Cardiology 2014年第1期11卷 32-38页

作者： Song ZHANG Yong-Yi BAI Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE Department of Geriatric Cardiology Chinese PLA General Hospital No.28 Fuxing Road Beijing 100853 China School of Medicine Nankai University N0.94 Weijin Road Tianjin 300071 China

Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arte- rial stiffness （carotid-femoral pulse wave velocity （PWV） and carotid-radial PWV） in 780 participants （46.3% men, mean age 71.9 years （ranging 65-96 years old）） from two communities of Beijing, China. Arterial stiffness were measured within two days of the time of bio- marker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV （standardized 13 = 0.13, P 〈 0.001）, even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for ca-rotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.

关键词： The elderly Homocysteine Arterial stiffness pulse wave velocity

Plasma homocysteine levels are independently associated with alterations of large artery stiffness in men but not in women

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Journal of Geriatric Cardiology 2015年第3期12卷 251-256页

作者： Li SHENG Cai WU Yong-Yi BAI Wen-Kai XIAO Dan FENG Ping YE Department of Geriatric Cardiology Chinese PLA General Hospital Beijing China Department of Medical Statistics Chinese PLA General Hospital Beijing China

Objectives To investigate the associations of the plasma homocysteine levels with the alterations in arterial stiffness in a commu- nity-based cohort. The gender differences in these associations were examined. Methods We evaluated the relationship between plasma homocysteine levels to three measures of vascular ftmction [carotid-femoral pulse wave velocity （CF-PWV）, carotid-ankle PWV （CA-PWV） and heart rate corrected augmentation index （AI）] in 1680 participants （mean age： 61.5 years; 709 men, 971 women） from communities of Beijing, China. Results In univariate analysis, plasma homocysteine levels was positively related to the CF-PWV （r = 0.211, P 〈 0.0001） and CA-PWV （r = 0.148, P 〈 0.0001）, whereas inversely associated with AI （r = -0.052, P = 0.016）. In multiple linear regression models adjusting for covariants, plasma homocysteine remained positively related to the CF-PWV （standardized 13 = 0.065, P = 0.007） in total cases. When the groups of men and women were examined separately, plasma homocysteine remained positively associated with the CF-PWV （standardized β = 0.082, P = 0.023） in men, whereas the relations between homocysteine and any of the arterial stiffness indices were not further present in women. Conclusions In Chinese population, plasma homocysteine levels are independently associated with alterations of large artery stiffness in men but not in women.

关键词： Arterial stiffness Gender differences Homocysteine pulse wave velocity

Association between dairy intake,lipids and vascular structure and function in diabetes

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World Journal of Diabetes 2017年第5期8卷 202-212页

作者： Kristina S Petersen Jennifer B Keogh Natalie Lister Jacquelyn M Weir Peter J Meikle Peter M Clifton School of Pharmacy and Medical Sciences and Sansom Institute for Health Research University of South Australia Baker IDI Heart and Diabetes Institute

AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** Serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.

关键词： Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness pulse wave velocity Diabetes