Association between dairy intake,lipids and vascular structure and function in diabetes

作     者：Kristina S Petersen Jennifer B Keogh Natalie Lister Jacquelyn M Weir Peter J Meikle Peter M Clifton 

作者机构：School of Pharmacy and Medical Sciences and Sansom Institute for Health ResearchUniversity of South Australia Baker IDI Heart and Diabetes Institute 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2017年第8卷第5期

页      面：202-212页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Heart Foundation and the Government of South Australia,No.CR 12A 6750 to Keogh JB NHMRC Principal Research Fellowship,No.APP1125691 to Clifton PM NHMRC Senior Research Fellowship,No.APP1042095 to Meikle PJ an Australian Postgraduate Award,No.138093 to Petersen KS a University of South Australia Postgraduate Award,No.128123 to Lister N 

主　　题：Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness Pulse wave velocity Diabetes 

摘      要：AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** Serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P 0.05). The 3-mo change in some lipids was positively associated with the 3-mo change in central systolic [LPC 14:0(rho 0.30; P = 0.007), PC 30:0(rho 0.28; P = 0.010)] and diastolic blood pressure [LPC 14:0(rho 0.32; P = 0.004), LPC 15:0(rho 0.23; P = 0.04), LPC 16:1(rho 0.23; P = 0.035), PC 29:0(rho 0.28; P = 0.01), PC 30:0(rho 0.36; P = 0.001), PC 31:0(rho 0.30; P = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0(rho 0.22; P = 0.02)]. Pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.