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Relationship between Neutrophil-to-Lymphocyte Ratio and pulse wave velocity in Young Patients with Systemic Lupus Erythematosus

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Chinese Medical Journal 2018年第1期131卷 10-15页

作者： Xu-Fei Yang Fa-Ming Ding Yi-Cong Ye Shu-Yang Zhang Department of Cardiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China

Background： The incidence of atherosclerosis-related myocardial infarction can be as much as 50-fold greater in young patients with systemic lupus e~,thematosus （SLE） than in age-matched controls. There are several explanations for this phenomenon, all of which result in a chronic state of low-grade inflammation. Recently, the neutrophil-to-lynlphocyte ratio （NLR） has been proposed as a useliil biomarker of inflammation. pulse wave velocity （PWV） is a reliable indicator of vascular damage and atherosclerosis. There is a paucity of data concerning the relationship between NLR and atherosclerosis as measured by PWV in patients with SLE. This study aimed to verify whether there is a positive correlation between NLR and PWV and to explore factors that influence PWV in young SLE patients. Methods： A total of 90 female patients with SLE were enrolled in this cross-sectional investigation. Traditional and nontraditional cardiovascular risk factors were assessed on the same day that brachial-ankle PWV （baPWV） was examined. The patients were divided into three groups according to their mean baPWV values： patients whose mean baPWV value was lower than the first tertile were placed in Group 1 ： patients whose mean baPWV value was between the first tertile and the second tertile were placed in Group 2： and patients whose mean baPWV value was higher than the second tertile were placed in Group 3. SPSS 20.0 was used to perform all statistical analyses in this study. Both univariate linear regression and multivariate regression models were utilized to analyze the association between NLR and arterial stiffness. Results： Systolic blood pressure, diastolic blood presstire （DBP）. and triglycerides were all significantly different among Groups 1,2, and 3 （ 111.90 ± 12.85 mmHg vs. 114.60 ± 12.88 mmHg vs. 129.43 ±16.21 mmHg, P 〈 0.001 ： 68.77 ± 8.63 mmHg vs. 71.87 ± 9.77 mmHg vs. 82.57 ± 14.89 mmHg, P 〈 0.001 ; and 1.44 [0.91-2.47] mmol/L vs. 0.98 [0.78-1.26] mmol/L vs. 2.20 [0.94-3.66]

关键词： Arterial Stiffness: Neutrophil-to-Lymphocyte Ratio pulse wave velocity Systemic Lupus Erythematosus

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Relationship of plasma level of Lp-PLA_2 and pulse wave velocity and carotid intima-media thickness

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South China Journal of Cardiology 2014年第4期15卷 261-266页

作者： LUO Ying WANG Li-li LONG Juan CHEN Qi-ying HU Wei Cardiovascular Department of Sun Yat-sen Cardiovascular Hospital

Background Increased plasma level of Lp-PLA2 is a potential risk factor for atherosclerosis. Nevertheless, whether Lp-PLA2 has effects on both vascular function and structure changes is still unclear. Method One hundred and eighty-six outpatient subjects without overt cardiovascular disease were enrolled and anthropomet- ric data, plasma level of Lp-PLA2 and other related laboratory parameters were collected. Measurements of pulse wave velocity （PWV） and carotid intima-media thickness （CIMT） were performed by an experienced investigator. According to plasma level of Lp-PLA2, all the subjects were divided into two groups as follows：〈 200 ng/mL （n = 96） and ≥200 ng/mL （n = 90）. Result Body mass index, smoking, diabetic mellitus, systolic blood pressure, and LDL-C level were positive correlation with plasma level of Lp-PLA2, while use of statins was negatively correlative. Both PWV and CIMT positively correlated with smoking, systolic blood pressure, LDL-C level and plasma level of Lp-PLA2, while negatively correlated with HDL-C level and usage of statins. CIMT in the group with plasma level of Lp-PLA2 〈 200 ng/mL （0.9 ± 0.2 mm, n = 96） was sig- nificantly less than that with plasma level of Lp-PLA2≥200 ng/mL （1.2 ±0.4 mm, n = 90, P = 0.32）, and similar finding was also observed in PWV （9.1± 0.5 m/s vs 12.7 ± 0.4 m/s, P = 0.38）. Conclusion Our present study shows that in subjects without overt CVD, increased plasma level of Lp-PLA2 is associated with vascular function （PWV） and structure （CIMT） deterioration.

关键词： lipoprotein-associated phospholipase A2 carotid intima-media thickness pulse wave velocity

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Brachial-ankle pulse wave velocity is an independent predictor of carotid artery atherosclerosis in the elderly

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Journal of Geriatric Cardiology 2010年第3期7卷 157-160页

作者： Jia-Yue Li Yu-Sheng Zhao Institute of Geriatric Cardiology Chinese PLA General HospitaLBeijing 100853 China

Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the *** also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly

关键词： Aortic stiffness carotid arteriosclerosis pulse wave velocity

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Altered heart rate variability and pulse-wave velocity after spinal cord injury

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World Journal of Clinical Cases 2022年第27期10卷 9680-9692页

作者： Hsi-Kai Tsou Kuan-Chung Shih Yueh-Chiang Lin Yi-Ming Li Hsiao-Yu Chen Functional Neurosurgery Division Neurological InstituteTaichung Veterans General HospitalTaichung 404Taiwan Department of Rehabilitation Jen-Teh Junior College of MedicineNursing and ManagementMiaoli County 356Taiwan College of Health National Taichung University of Science and TechnologyTaichung 403Taiwan College of Medicine National Chung Hsing UniversityTaichung 402Taiwan Research Assistant The Rong Sing Medical FoundationTaichung 404Taiwan Research Assistant Neurological InstituteTaichung Veterans General HospitalTaichung 404Taiwan Research Assistant Department of NursingNational Taichung University of Science and TechnologyTaichung 403Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and TechnologyTaipei 106Taiwan Department of Nursing National Taichung University of Science and TechnologyTaichung 403Taiwan

BACKGROUND Heart rate variability(HRV) and pulse-wave velocity(PWV),indicators of cardiac function,are altered in patients with spinal cord injury(SCI),suggesting that autonomic cardiac function and arterial stiffness may underlie the high risk of cardiovascular complications in these *** study has simultaneously investigated HRV and PWV in the same *** To evaluate cardiovascular complications in SCI patients by comparing HRV and PWV between patients with and without *** In this cross-sectional pilot study,patients with(n = 60) and without SCI(n = 60) were recruited from December 7,2019 to January 21,*** participant received a five-minute assessment of HRV and the cardiovascular system using the Medicore HRV Analyzer SA-3000 *** in HRV and PWV parameters between participants with and without SCI were statistically *** We observed a significant difference between participants with and without SCI with respect to the standard deviation of all normal-to-normal intervals,square root of the mean sum of squared successive risk ratio interval differences,physical stress index,total power,very-low frequency,low frequency,high frequency,and arterial *** Patients with SCI have weaker sympathetic and parasympathetic activity as well as lower arterial elasticity compared to those without,suggesting that SCI may increase cardiac function loading.

关键词： Acceleration plethysmography Cardiac function Heart rate variability pulse wave velocity Spinal cord injury

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The value of pulse wave velocity in the diagnosis of coronary heart disease

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Journal of Medical Colleges of PLA(China) 2006年第4期21卷 254-257页

作者：贾新未刘铭雅魏盟陆志刚 Cardiac Department Affiliated Hospital of Hebei UniversityBaoding 071000China Cardiac Department Shanghai Sixth People's HospitalShanghai 200233China

Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.

关键词： coronary heart disease coronary angiography pulse wave velocity receiver operating characteristic diagnosis

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Correlations between ultrasonic pulse wave velocities and rock properties of quartz-mica schist

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第3期10卷 594-602页

作者： Bharti Chawre Central Soil and Materials Research Station New Delhi110016India

Physico-mechanical properties are critically important parameters for rocks. This study aims to examine some of the rock properties of quartz-mica schist（QMS） rocks in a cost-effective manner by establishing correlations between non-destructive and destructive tests. Using simple regression analysis, good correlations were obtained between the pulse wave velocities and the properties of QMS rocks. The results were further improved by using multiple regression analysis as compared to those obtained by the simple linear regression analysis. The results were also compared to the ones obtained by other empirical equations available. The general equations encompassing all types of rocks did not give reliable results of rock properties and showed large relative errors, ranging from 23% to 1146%. It is suggested that empirical correlations must be investigated separately for different types of rocks. The general empirical equations should not be used for the design and planning purposes before they are verified at least on one rock sample from the project site, as they may contain large unacceptable errors.

关键词： pulse wave velocity Physico-mechanical properties Quartz-mica schist (QMS) rocks Non-destructive methods Static elastic constants Dynamic elastic constants

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Association between dairy intake,lipids and vascular structure and function in diabetes

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World Journal of Diabetes 2017年第5期8卷 202-212页

作者： Kristina S Petersen Jennifer B Keogh Natalie Lister Jacquelyn M Weir Peter J Meikle Peter M Clifton School of Pharmacy and Medical Sciences and Sansom Institute for Health Research University of South Australia Baker IDI Heart and Diabetes Institute

AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** Serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.

关键词： Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness pulse wave velocity Diabetes

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Short Sleep Duration is Associated with Central Arterial Stiffness in Children Independent of Other Lifestyle Behaviors

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Journal of Science in Sport and Exercise 2020年第3期2卷 236-245页

作者： Lee Stoner Simon Higgins Katherine Black Kim Boggess Michelle L.Meyer Andrea Chou Barbara Galland Jillian J.Haszard Kim Meredith-Jones Pouya Saeedi Sheila Skeaff Paula M.L.Skidmore Department of Exercise and Sport Science University of North Carolina at Chapel HillChapel HillNCUSA Department of Exercise Science Elon UniversityElonNCUSA Department of Human Nutrition University of OtagoDunedinNew Zealand Division of Maternal-Fetal Medicine School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Emergency Medicine School of MedicineUniversity of North Carolina at Chapel HillChapel HillNCUSA Department of Women and Childrens Health University of OtagoDunedinNew Zealand Department of Medicine University of OtagoDunedinNew Zealand Department of Medicine University of OtagoChristchurchNew Zealand

Purpose Children require 9-11 h sleep to ensure adequate growth and development by optimizing the efficiency of a number of biological systems,including the cardiovascular *** study aim was to determine whether short sleep duration(pulse wave velocity(cfPWV),sleep duration,time spent sedentary,and moderate-vigorous physical activity were measured using wrist actigraphy,and dietary patterns using a food frequency ***-tions between short sleep duration and cfPWV were examined using mixed effects *** There was a positive[unadjusted]association between short sleep duration and cfPWV(β=0.245,95%CI 0.093-0.396).This association persisted following adjustment for demographic factors and was strengthened following adjustment for lifestyle behaviors(β=0.331,95%CI 0.109-0.553).Conclusions Short sleepers(<9 h)had a clinically meaningful elevated aortic arterial stiffness in comparison to those sleeping the recommended daily 9-11 *** duration may be important for cardiovascular health independent of other lifestyle behaviors.

关键词： pulse wave velocity Cardiovascular disease Sedentary behaviour Physical activity Diet

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Effects of Zhibitai capsules on blood lipids and arterial elasticity

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中国现代医学杂志 2011年第3期21卷 330-335页

作者： Sheng-ying Jia Quan-yue Huang Department of Cardiology the Second Xiangya Hospital Central South University Changsha Hunan 410011P.R.China

Objective To evaluate the effects of Zhibitai(ZBT) on blood lipids and arterial elasticity in patients with high cardiovascular *** Eighty three subjects with high risk factors of cardiovascular diseases were enrolled into the study and randomized to two groups,i.e.,the ZBT group(n =44,treated with ZBT 0.48 g twice per day) and the atorvastatin(ATO) group(n =39,treated with ATO 10 mg per day).The levels of fasting serum lipids including total cholesterol(TC),triglyceride(TG),high and low density lipoprotein cholesterol(HDL-C and LDL-C) and pulse wave velocity(PWV) were investigated before and eight weeks after *** The serum levels of TG,TC,LDL-C,femoral-ankle PWV(FAPWV) and carotid-radial PWV(CRPWV) were markedly decreased after the therapy with ZBT or ATO for 8 weeks(P 0.05) after eight-week's *** ZBT could reduce the levels of FAPWV and CRPWV,thus improve the elasticity of medium-sized peripheral muscular arteries in addition to its lipids lowering *** efficacy of ZBT is similar to that of ATO.

关键词： Zhibitai capsule atorvastatin blood lipid arterial elasticity pulse wave velocity

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Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components

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Chinese Medical Journal 2013年第16期126卷 3097-3102页

作者： SUN Ning ZHANG Yun TIAN Jian-li WANG Hui Department of Gerontology Tianjin General Hospital TianjinMedical University Tianjin 300052 China

Background High uric acid （UA） levels and metabolic syndrome （MS） are risk factors for atherosclerotic ***-ankle pulse wave velocity （baPWV） is a valid and reproducible measurement by which to assess arterial stiffness and a surrogate marker of ***,little is known about the relationship between them,especially in elderly Chinese with MS components who are at high risk for atherosclerotic *** One thousand and twenty Chinese subjects （159 women） older than 60 years of age （mean age （70.6±5.7）years） with at least one MS component underwent routine laboratory tests,and baPWV measurements were *** Participants were divided into four groups by MS *** mean age did not significantly differ among the MS component *** found that not only the diagnostic factors （blood pressure,body mass index （BMI）,lipids,glucose） of MS but also baPWV,UA,insulin,homeostasis model of assessment for insulin resistence index （HOMAIR） levels increased,and high density lipoprotein （HDL）-C decreased with an increased number of MS components （test for trend P＜0.05）.The association between UA and baPWV was observed after adjustment for gender,age,blood pressure,BMI,serum creatinine and high density lipoprotein,and insulin resistance （r=0.186,P＜0.0001）.There were increases in the odds ratios for the association between the number of components of MS,UA and baPWV,even after adjustment for traditional risk ***,after adjustment for insulin or HOMA-IR,there were no significant differences in the multivariate odds ratios among the number of MS components for *** The UA level is positively associated with baPWV and MS,but the association between UA and MS is dependent on insulin ***,baPWV is independently associated with MS in our study population.

关键词： uric acid pulse wave velocity metabolic syndrome

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