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Nutritional status in chronically hospitalized stroke patients complicated with pulmonary infection

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Neural Regeneration Research 2011年第13期6卷 1037-1040页

作者： Yue Chen Lufang Chen Yiqing Tao Maomao Han Chunlan Cui Shichao Liu Department of Geriatrics First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China College of Medicine Hangzhou Normal University Hangzhou 310018 Zhejiang Province China

Complicated pulmonary infection following stroke has traditionally been considered an aspirated infection by many physicians, and little attention has been paid to concomitant protein-energy malnutrition. In the present study, we hypothesized that protein-energy malnutrition may be present in hospitalized chronic stroke patients complicated with pulmonary infection. The results revealed that body protein and fat stores were significantly depleted in stroke patients with pulmonary infection. Protein-energy malnutrition was present in 12 of 27 patients with pulmonary infection. In comparison, only eight of 42 stroke patients without pulmonary infection exhibited protein-energy malnutrition. A significantly higher prevalence of protein-energy malnutrition was found in the pulmonary infection group, suggesting that protein-energy malnutrition is more likely to be present in hospitalized chronic stroke patients with pulmonary infection.

关键词： nutritional status protein-energy malnutrition stroke pulmonary infection

Development and validation of a postoperative pulmonary infection prediction model for patients with primary hepatic carcinoma

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1241-1252页

作者： Chao Lu Zhi-Xiang Xing Xi-Gang Xia Zhi-Da Long Bo Chen Peng Zhou Rui Wang Department of Hepatobiliary&Pancreaticospleen Surgery Yangtze UniversityJing Zhou hospitalJingzhou 434020Hubei ProvinceChina

BACKGROUND There are factors that significantly increase the risk of postoperative pulmonary infections in patients with primary hepatic carcinoma(PHC).Previous reports have shown that over 10%of patients with PHC experience postoperative pulmonary ***,it is crucial to prioritize the prevention and treatment of postoperative pulmonary infections in patients with *** To identify the risk factors for postoperative pulmonary infection in patients with PHC and develop a prediction model to aid in postoperative *** We retrospectively collected data from 505 patients who underwent hepatobiliary surgery between January 2015 and February 2023 in the Department of Hepatobiliary and Pancreaticospleen *** data were selected for statistical analysis,and clinical pathological parameters and imaging data were included in the screening database as candidate predictive *** then developed a pulmonary infection prediction model using three different models:An artificial neural network model;a random forest model;and a generalized linear regression ***,we evaluated the accuracy and robustness of the prediction model using the receiver operating characteristic curve and decision curve *** Among the 505 patients,86 developed a postoperative pulmonary infection,resulting in an incidence rate of 17.03%.Based on the gray-level co-occurrence matrix,we identified 14 categories of radiomic data for variable screening of pulmonary infection prediction *** these,energy,contrast,the sum of squares(SOS),the inverse difference(IND),mean sum(MES),sum variance(SUV),sum entropy(SUE),and entropy were independent risk factors for pulmonary infection after hepatectomy and were listed as candidate variables of machine learning prediction *** random forest model algorithm,in combination with IND,SOS,MES,SUE,SUV,and entropy,demonstrated the highest prediction efficiency in both the training and internal verificatio

关键词： Primary hepatic carcinoma pulmonary infection Gray-level co-occurrence matrix Machine learning Prediction

Clinical diagnosis,treatment,and medical identification of specific pulmonary infection in naval pilots:Four case reports

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World Journal of Clinical Cases 2022年第16期10卷 5487-5494页

作者： Jia Zeng Guo-Li Zhao Jia-Cheng Yi Dan-Dan Liu Yan-Qing Jiang Xiang Lu Yan-Bing Liu Fei Xue Jie Dong Department of Aviation Disease Naval Medical Center of PLAShanghai 200052China Department of Radiology Naval Medical Center of PLAShanghai 200052China Department of Clinical Medicine School of Basic MedicineHebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Department of Respiratory Medicine Changhai HospitalNaval Military Medical UniversityShanghai 200081China

BACKGROUND Specific pulmonary infection could seriously threaten the health of pilots and their *** consequences are *** investigated the clinical diagnosis,treatment,and medical identification of specific pulmonary infections in naval *** SUMMARY We analyzed the medical waiver and clinical data of four pilots with specific pulmonary infections,who had accepted treatment at the Naval Medical Center of Chinese People’s Liberation Army between January 2020 and November 2021,including three cases of tuberculosis and one of cryptococcal *** cases underwent a series of comprehensive treatment *** cases successfully obtained medical waiver for flight after being cured,while one was grounded after reaching the maximum flight life after being *** Chest computed tomography scanning should be used instead of chest radiography in pilots’physical *** pilots with specific pulmonary infection can be cured and return to flight.

关键词： Cryptococcal pneumonia Tuberculosis Diagnosis Treatment Medical identification Pilot pulmonary infection Case report

Secondary pulmonary infection by Fusarium solani and Aspergillus niger during systemic steroid treatment for COVID-19:A case report

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世界临床病例杂志 2023年第26期11卷 6280-6288页

作者： Daisuke Usuda Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Juntendo UniversityBunkyo 113-8421TokyoJapan

BACKGROUND Coronavirus disease 2019(COVID-19)-associated invasive pulmonary aspergillosis presents a diagnostic challenge due to its non-specific clinical/imaging features,as well as the fact that the proposed clinically diagnostic algorithms do not necessarily apply to COVID-19 *** addition,Fusarium *** a rare cause of opportunistic life-threatening fungal *** Fusarium infection in an immunocompromised host is intractable,with a high likelihood of resulting *** our knowledge,this is the first case of secondary pulmonary infection by Fusarium solani(***)and Aspergillus niger(***)during systemic steroid treatment for *** SUMMARY A 62-year-old male was transported to our hospital by ambulance with a complaint of fever and *** established a diagnosis of pneumococcal pneumonia,complicated with COVID-19 and septic shock,together with acute renal *** was admitted to the intensive care unit,to be treated with piperacillin/tazobactam,vancomycin,and 6.6 mg per day of dexamethasone sodium phosphate,along with noradrenaline as a vasopressor,ventilator management,and continuous *** condition improved,and we finished the vasopressor on the fifth hospital *** administered dexamethasone for ten days,and finished the course of *** the eleventh day,patient respiratory deterioration was observed,and a computed tomography scan showed an exacerbation of bilateral ground-glass-opacity-like consolidation,together with newly appeared cavitary lesions in the *** changed antibiotics to meropenem plus *** addition,a fungal infection was considered as a possibility based on microscopic findings of sputum,and we began coadministration of ***,the pneumonia worsened,and the patient died on the seventeenth day of ***,*** and *** were identified from sputum collected on the twelfth *** was believed that he developed a cell-mediated immune defic

关键词： Fusarium solani Aspergillus niger pulmonary infection Cell-mediated immune deficiency Coronavirus disease 2019 Case report

Expression of IL-4 in a rat model of chronic pulmonary infection with biofilm formation induced by Pseudomonas aeruginosa

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Journal of Microbiology and Immunology 2007年第1期5卷 23-28页

作者： PING YAN YI QIANG CHEN JIN LIANG KONG ZHI JUN SONG HONG WU Geriatric Respiratory Disease Ward the First Affiliated Hospital of Guangxi Medical University Nanning P. R. China

The expression of IL-4 in a rat model of chronic pulmonary infection biofilm formation induced by Pseudomonas aeruginosa was investigated, in which SPF Wister rats were infected via trachea with 0.1 ml P. aeruginosa strain PAO579 （ 10^9 CFU/ml） in alginate beads or the planktonic form of this bacterial strain （109 CFU/ml）, and on 3, 7 and 14 d after infection, the bacteriological and pathological changes were observed as well as the expression of the cytokine IL-4 was determined. It was demonstrated that the count of CFU per lung tissue in case of bacteria in alginate beads was significantly higher than that of bacteria in planktonic form, with more severe gross pathologic changes and inflammatory reactions in the alginate bead group in comparison with that of the planktonic forms （ P = 0. 002, P = 0. 004 and P = 0. 002, respectively）. In addition, the expression of IL-4 in the alginate bead group was also higher than that in the planktonic form （P = 0.02, P = 0.02 and P = 0.022, respectively）. A positive correlation between the level of IL-4 expression and the gross lung pathology in alginate bead group existed as demonstrated by simple regression analysis （r = 0.78, P 〈 0.02）. It is concluded that the chronic pulmonary infection with biofilm formation induced by P. aeruginosa tends to have the priority to the Th2 immune response.

关键词： P. aeruginosa Biofilm pulmonary infection Interleukin-4

Antibacterial activity of panipenem/betamipron in vitro and its pharmacokinetics and therapeutic efficacy in patients with pulmonary infection

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Journal of Medical Colleges of PLA(China) 2005年第2期20卷 119-123页

作者：刘刚李军梅杨和平何菊英唐春兰刘松青刘平胡建林 Department of Respiratory Diseases Southwest Hospital Third Military Medical University

Objective: To investigate the in vitro antimicrobial activity of panipenem/betamipron to common clinical isolates, determine its pharmacokinetics in patients with pulmonary infection and evaluate its effectiveness and safety in treatment of pulmonary infection. Methods: (1) The minimal inhibition concentrations of panipenem/betamipron were determined in 247 clinical isolates by agar dilution method. The minimal bactericidal concentrations of panipenem/betamipron for some clinical isolates were also determined. (2) Twenty cases of pulmonary infection were treated with intravenous dripping of panipenem/betamipron at 500/500 mg every 12 h for 3-7 d. Panipenem/betamipron concentration in the plasma was consecutively measured, and bacterial culture was conducted and the efficacy was evaluated. Results: (1) The in vitro antimicrobial activity of panipenem/betamipron was almost the same as that of panipenem, indicating that panipenem played the major role in antimicrobial reaction. Panipenem/betamipron had a strong antimicrobial activity against Staphylococcus aureus including methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, β-Streptococcus hemolytic, Streptococcus pneumonia, micrococcus, Escherichia coli and Klebsiea pneumonia. The drug also showed a potent effect against Haemophilus influenzae,Enterobacter cloacae, Proteus and Pseudomonas aeruginosa (2) The peak value of panipenem/betamipron in plasma was (30.25±5.43) mg/L and the level decreased to (0.66±0.34) mg/L 6 h later. The half-life of distribution and elimination of panipenem in the plasma was (0.34±0.18) h and (1.42±0.31) h, respectively. (3) The eradication rate of bacteria was 77.8% and the effective healing rate was 75%. No adverse drug reaction was found. Conclusion: Panipenem/betamipron has a strong antimicrobial activity against clinical isolates and is effective and safe for treatment of pulmonary infection.

关键词： panipenem/betamipron antimicrobial activity pharmacokinetics pulmonary infection

Study on Characteristics and Influencing Factors of Coagulation Indexes in pulmonary infection Sepsis

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Journal of Clinical and Nursing Research 2022年第1期6卷 122-125页

作者： Pan Wei Xuanguo Zhang Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina Shaanxi Provincial Hospital of Chinese Medicine Xi‘an 710000Shaanxi ProvinceChina

Objective:To explore the characteristics and influencing factors of coagulation indexes in patients with pulmonary infection ***:104 patients in Shaanxi Provincial Hospital of Chinese Medicine from January 2015 to April 2021 were collected and divided into case group(52 cases)and control group(52 cases).The general data and coagulation indexes of the two groups were statistically *** difference was statistically significant(P0.05);Binary logistic regression analysis showed that D-Dimer and PLT were the risk factors of pulmonary infection sepsis(OR>1,P<0.05).Conclusion:FDP and D-Dimer are risk factors for the development of pneumonia into sepsis.

关键词： Sepsis pulmonary infection Coagulation index Influencing factors

Clinical analysis on nosocomial pulmonary infection in patients with indwelling tracheal tube

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Discussion of Clinical Cases 2015年第4期2卷 22-26页

作者： Jin Guo Shuna Shen Chunyan Qu Cuiping Yan Comprehensive Surgery Department The Third Affiliated Hospital of Inner Mongolia Medical UniversityChina

Tracheal intubation by tracheotomy or by placing a tracheal tube through larynx into trachea,is not only one of important measures which are taken to rescue critically ill patients with respiratory failure etc.,but a commonly used method to prevent patients from airway obstruction in the postoperative period and facilitate mechanical ***,the incidence rate of pulmonary infection,a complication caused by indwelling tracheal tubes,especially the incidence rate of hospital acquired pulmonary infection is apparently ***,pulmonary infection of this kind has characteristics of easily recurrent seizures,long treatment period and high ***,it is required for medical personnel to summarize,analyze and study not only general nursing,airway nursing and prevention of pulmonary infection,but also antibiotic selection as well as how and when to use those drugs after the incidence of pulmonary infection for the benefit of patients with indwelling tracheal *** article is based on a case collected from Comprehensive Surgery Department of the Third Affiliated Hospital of Inner Mongolia Medical *** patient’s history is as follows:*** infection;*** tracheal catheter after tracheotomy;*** monoxide toxic cerebrosis,mute *** means of this case analysis,it is expected to make an early detection,and give an early and proper treatment to patients with pulmonary infection caused by indwelling tracheal tubes in clinical practice.

关键词： Indwelling tracheal tube Nosocomial infection pulmonary infection

Risk factors and subsequent prognostic impact of pulmonary infection in patients with acute myocardial infarction undergoing IABP implantation

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South China Journal of Cardiology 2020年第2期21卷 123-127页

作者： LIANG Xiu-na YU Li-ting LIAO You-wan Department of Critical Care Medicine Guangdong Provincial Geriatrics InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Background Mortality in patients with acute myocardial infarction(AMI)undergoing an intra-aortic balloon pump(IABP)implantation remains *** study aims to analyze the risk factors and subsequent prognostic impact of pulmonary infection in these *** Data of patients with AMI treated with the IABP between August 2017 and May 2018 was collected retrospectively.A total of 104 AMI patients who underwent the IABP and complicated with postoperative pulmonary infection were assigned to the observation group,meanwhile,73 patients without pulmonary infection were chosen as the control *** clinical characteristics were compared between two groups of patients,the risk factors and outcomes for the postoperative pulmonary infections were *** pulmonary infection can prolong CCU duration(11.7±8.2 vs.6.5±4.1,P2 was an independent risk factor for pulmonary *** addition,multivariate logistic regression analysis indicated that Killip>2,diabetes,current smoking,and pulmonary infection were independently associated with in-hospital *** Postoperative pulmonary infection was a risk factor for poor outcomes in patients with AMI undergoing *** is necessary to take corresponding interventions to reduce the risk of postoperative pulmonary infection.

关键词： acute myocardial infarction intra-aortic balloon pump pulmonary infection