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Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences

Progress in Natural Science:Materials International 2008年第1期18卷 13-20页

作者： Guanghua Wu a,b, Huiguo Ding c, Changqing Zeng b,* a Graduate School of Chinese Academy of Sciences, Beijing 100049, China b Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China c Beijing Youan Hospital, Capital Medical University, Beijing 100069, China Graduate School of Chinese Academy of Sciences Beijing 100049 China Beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China Beijing Youan Hospital Capital Medical University Beijing 100069 China

The number of Hepatitis B virus (HBV) whole genomic sequences in public nucleotide databases (GenBank, EMBL, and DDBJ) had reached 866 by January 1, 2007. Coming from 46 countries and regions, these sequences were categorized as eight genotypes (A–H). With the statistical and phylogenetic analysis on all available complete genomic data of HBV, we here present an overview of HBV sequences in public databases. From all registered 229 HBV genomes in Chinese regions as well as 59 sequencing data from our research group, we report the establishment of reference sequences of HBV strains prevailing in China. These analyses provide clues for the effects of HBV genotypes in host clinical progressions, geographic distribution of the infection, and the viral evolutionary history. Moreover, the viral sequence reference would be helpful in the identiffcation of various HBV mutations. Based on the analysis of various public databases, we suggest that the Chinese HBV database with the clinical information should be constructed.

关键词： public databases HBV genomic sequences Genotype Subtype Chinese reference sequences

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Comprehensive analysis of TPX2 in Head and neck squamous cell carcinoma with prognostic values

Comprehensive analysis of TPX2 in Head and neck squamous cel...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： miaomiao chen wenjun cao Eye and ENT Hospital of Fu Dan University

Objective: Targeting protein for Xenopus kinesin-like protein 2(TPX2) is a microtubule-associated protein required for mitosis and spindle assembly. It has been revealed that TPX2 is overexpressed in various human cancers and promotes cancer progression, while its role in head and neck squamous cell carcinoma is unknown. We aimed to demonstrate the relationship between TPX2 and head and neck squamous cell ***: This study investigated the expression and roles of TPX2 in HNSC using Oncomine, The Cancer Genome Atlas, UALCAN, Human Protein Atlas, Clinical Proteomics Tumor Analysis Consortium,GeneMANIA, Tumor IMmune Estimation Resource, GEPIA ***: High mRNA and protein expression of TPX2 were found to be significantly associated with clinical cancer stages, nodal metastasis status, and patient’s gender in HNSC ***: Taken together, these results indicated that TPX2 could be a potential target in the development of anti-HNSC therapeutics and an efficient marker of the prognostic value of HNSC.

关键词： head and neck squamous cell carcinoma TPX2 public databases prognostic value comprehensive analysis

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