Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences
Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences作者机构：Graduate School of Chinese Academy of Sciences Beijing 100049 China Beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China Beijing Youan Hospital Capital Medical University Beijing 100069 China
出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期：2008年第18卷第1期
页 面：13-20页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100103[医学-病原生物学] 0702[理学-物理学] 10[医学]
基 金：KSCX2-SW-207 Beijing Municipal Education Commission: KM20070025024
主 题：Public databases HBV genomic sequences Genotype Subtype Chinese reference sequences
摘 要：The number of Hepatitis B virus (HBV) whole genomic sequences in public nucleotide databases (GenBank, EMBL, and DDBJ) had reached 866 by January 1, 2007. Coming from 46 countries and regions, these sequences were categorized as eight genotypes (A–H). With the statistical and phylogenetic analysis on all available complete genomic data of HBV, we here present an overview of HBV sequences in public databases. From all registered 229 HBV genomes in Chinese regions as well as 59 sequencing data from our research group, we report the establishment of reference sequences of HBV strains prevailing in China. These analyses provide clues for the effects of HBV genotypes in host clinical progressions, geographic distribution of the infection, and the viral evolutionary history. Moreover, the viral sequence reference would be helpful in the identiffcation of various HBV mutations. Based on the analysis of various public databases, we suggest that the Chinese HBV database with the clinical information should be constructed.
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