检索结果-南通市图书馆

Cognitive magnetic resonance imaging-ultrasound fusion transperineal targeted biopsy combined with randomized biopsy in detection of prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第36期9卷 11183-11192页

作者： Cheng Pang Miao Wang Hui-Min Hou Jian-Yong Liu Zhi-Peng Zhang Xuan Wang Ya-Qun Zhang Chun-Mei Li Wei Zhang Jian-Ye Wang Ming Liu Department of Urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Graduate School of Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China Department of Radiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina Department of Pathology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730BeijingChina

BACKGROUND prostate cancer(PCa)is one of the most common cancers among *** strategies for targeted biopsy based on multiparametric magnetic resonance imaging(mp-MRI)have emerged,which may improve the accuracy of detecting clinically significant PCa in recent *** To investigate the diagnostic efficiency of a template for cognitive MRIultrasound fusion transperineal targeted plus randomized biopsy in detecting *** Data from patients with an increasing prostate-specific antigen(PSA)level but less than 20 ng/mL and at least one lesion suspicious for PCa on MRI from December 2015 to June 2018 were retrospectively *** patients underwent cognitive fusion transperineal template-guided targeted biopsy followed by randomized biopsy outside the targeted area.A total of 127 patients with complete data were included in the final analysis.A multivariable logistic regression analysis was conducted,and a two-sided Pprostate Imaging-Reporting and Data System(PI-RADS)scores(both P<0.001)were independently associated with the results of cognitive fusion targeted biopsy combined with randomized biopsy and targeted biopsy *** This single-centered study proposed a feasible template for cognitive MRIultrasound fusion transperineal targeted plus randomized *** with higher PSAD and PI-RADS scores were more likely to be diagnosed with PCa.

关键词： prostate neoplasms Magnetic resonance imaging Cognitive fusion prostate biopsy prostate cancer

Altered Expression of Connexin-43 and Impaired Capacity of Gap Junctional Intercellular Communication in prostate Cancer Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第3期27卷 291-294页

作者：邢毅飞肖亚军曾甫清赵军肖传国熊平冯玮 Institute of Urology Union HospitalSchool of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology Institute of Immunology School of Basic Medical Sciences Tongji Medical College Huazhong University of Science and Technology

Connexin-43 (Cx43) expression in prostate cancer (PCa) cells and the potency of gap junctional intercellular communication (GJIC) in the cells were investigated, with an attempt to elu- cidate the reason why the so-called 'bystander effect' mediated by thymidine kinase (TK) suicide gene therapy on PCa cells is not of significance and to explore the role of GJIC in PCa carcinogenesis. mRNA and protein expression of Cx43 in a PCa cell line PC-3m was detected by re- verse-transcription polymerase chain reaction (RT-PCR) and strapt-avidin-biotin-enzyme complex (SABC) immunohistochemical staining, and inherent GJIC of PC-3m cells was assayed by scrape-loading and dye transfer (SLDT) assay. The expression of Cx43 in human normal and malig- nant prostate tissues was determined by SABC immunohistochemistry as well. It was found that Cx43 mRNA and protein expression in PC-3m cells was slightly reduced as compared with positive controls and the location of Cx43 protein was aberrant in cytoplasm rather than on membrane. As- sessment of paraffin sections demonstrated that the expression of Cx43 protein in PCa cells was ab- normally located and markedly diminished as compared with normal prostatic epithelial ones, dis- playing a negative correlation to the pathological grade (χ2=4.025, P<0.05). Additionally, capacity of inherent GJIC in PC-3m cells was disrupted, which was semi-quantified as (+) or (-). It was indi- cated that both down-regulated expression of Cx43 mRNA and aberrant location of Cx43 protein par- ticipated in the mechanisms leading to deficient GJIC in PC-3m cells. Lack of efficient GJIC is a molecular event, which may contribute not only to limited extent of 'bystander effect', but also to initiation and progression of prostatic neoplasm.

关键词： prostate neoplasms gap junctional intercellular communication herpes simplex virus thymidine kinase gene/ganciclovir connexin bystander effect

Reduced expression of α-tocopherol-associated protein is associated with tumor cell proliferation and the-increased risk of prostate cancer recurrence

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2007年第2期9卷 206-212页

作者： Xing-Qiao Wen Xiao-Juan Li Zu-Lan Su Yong Liu Xiang-Fu Zhou Yu-Bin Cai Wen-Tao Huang Xin Gao Department of Urology Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Health Care Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Pathology Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

Aim： To examine the impact and prognostic significance of α-tocopherol associated protein （TAP） expression in a series of prostate cancer patients. Methods： Tissues from 87 patients underwent radical prostatectomy were examined for TAP expression by immunohistochemistry. The relationships of the staining results, the clinic pathological characteristics and the recurrence times were analyzed. Results： Compared with the adjacent areas of normal and benign glands, immunoreactivity of TAP was reduced in areas of prostate cancer. A lower TAP-positive cell number per mm^2 of the largest cancer area （defined as TAP-PN） was associated with higher clinical stage （r = -0.248, P = 0.0322）. Inverse associations were found among the TAP-PN and positive lymph nodes （r = -0.231, P = 0.0325）, preoperative prostatespecific antigen （PSA） levels （r = -0.423, P = 0.0043）, tumor size （r = -0.315, P = 0.0210） and elevated tumor cell proliferation, which was indicated by the staining of Ki-67 （r = -0.308, P = 0.0026）. TAP-PN was a significant predictor of recurrence univariately （P = 0.0006）, as well as multivariately, adjusted for known markers including preoperative PSA, clinical stage, Gleason score, surgical margin, extra-prostatic extension, seminal vesicle invasion and lymph node metastasis （P = 0.0012）. Conclusion： Reduced expression of TAP was associated with the cell proliferation status of prostate cancer, adverse pathological parameters and the increased risk of recurrence.

关键词： α-tocopherol associated protein prostate neoplasms recurrence vitamin E

Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第1期18卷 54-59页

作者： Eu Chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung Department of Urology Chonnam National University Medical School Gwangju Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju Republic of Korea Department of Radiology Chonnam National University Medical School Gwangju Republic of Korea Department of Hemato-oncology Chonnam National University Medical School Gwangju Republic of Korea Department of Neurosurgery Chonnam National University Medical Schoo Gwangju Republic of Korea

Several studies have revealed that the preoperative serum testosterone and percent tumor volume （PTV） predict extra-prostatic extension （EPE） and biochemical recurrence （BCR） after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy （LRP）. We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen （PSA）〉0.2 ng ml^-1. The threshold for serum total testosterone was 3.0 ng ml^-1, Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone （〈3.0 ng ml^-1） was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone （〈3.0 ng ml^-1, adjusted OR, 8.52; 95% CI, 5.04-14.4, P = 0.001） predicted EPE and PTV （adjusted OR, 1.02; 95% CI, 1.01-1.05, P = 0.046） predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.

关键词： biochemical recurrence extra-prostatic extension prostate neoplasms prostatectomy testosterone tumor burden

Detection of pim-1 mRNA in prostate cancer diagnosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第17期120卷 1491-1493页

作者： HE Hui-chan BI Xue-cheng DAI Qi-shan WANG Shao-sheng WEI Hong-ai ZHONG Wei-de LIU Wen-hua JIANG Fu-neng LIU Liang-shi Department of Urology First People＇s Hospital ot GuangzhouGuangzhou Medical College Guangzhou 510180 China College of Life Science Sun Yat-sen University Guangzhou510180 China

Background Pim-1 plays an important role in the apoptosis, proliferation, differentiation of cancer cells and progression of cancer. In this study we detected the expression of pim-1 mRNA in normal prostate, benign prostatic hyperplasia （BPH）, and prostate cancer （PCa） and explored its diagnostic value for PCa. Methods The prostate tissues were collected from 23 patients with PCa, 37 patients with BPH, and 3 healthy volunteers. Pim-1 mRNA expression levels in these samples were determined by the quantitative real-time PCR （QRT-PCR）. The differences of expression were calculated based on a standard curve. Results The ratio of pim-1 mRNA to β-actin in the normal prostate, BPH, and PCa were 1.05±0.04, 2.57±0.74 and 4.45±0.63, respectively. The differences among PCa, BPH and NT were significant （P〈0.05, respectively）. Conclusion Detecting pim-1 mRNA expression by QRT-PCR provides a reliable metric for the diagnosis of PCa.

关键词： proto-oncogene proteins c-pim-1 prostate neoplasms diagnosis

The expression of estrogen receptor-α and estrogen receptor-β in prostate cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The expression of estrogen receptor-α and estrogen receptor...