Mutation of MED12 is not a frequent occurrence in prostate cancer of Korean patients

作     者：Nara Yoon Sharon Lim So Young Kang Ghee Young Kwon Hwang Gyun Jeon Byong Chang Jeong Seong Il Seo Seong Soo Jeon Hyun Moo Lee Han Yong Choi 

作者机构：Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2017年第19卷第3期

页      面：346-349页

核心收录：

学科分类：10[医学] 

基　　金：supported by a grant from the Korean Foundation for Cancer Research 

主　　题：mediator complex subunit 12 mutation analysis prostate cancer prostate neoplasms 

摘      要：Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional ＂gold standard.＂