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Significance of 125I radioactive seed implantation on growth differentiation factor and programmed death receptor-1 during treatment of oral cancer

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World Journal of Clinical Cases 2020年第5期8卷 874-886页

作者： Gang Xue Yao Feng Jia-Bin Li Department II of Prosthodontics The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department I of Endodontics The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department II of Oral and Maxillofacial Surgery The Second Affiliated Hospital of Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina

BACKGROUND Oral cancer(OC)is the most common malignant tumor in the oral cavity,and is mainly seen in middle-aged and elderly *** present,OC is mainly treated clinically by surgery or combined with radiotherapy and chemotherapy;but recently,more and more studies have shown that the stress trauma caused by surgery and the side effects of radiotherapy and chemotherapy seriously affect the prognosis of *** To determine the significance of 125I radioactive seed implantation on growth differentiation factor 11(GDF11)and programmed death receptor-1(PD-1)during treatment of *** A total of 184 OC patients admitted to The Second Affiliated Hospital of Jiamusi University from May 2015 to May 2017 were selected as the research subjects for prospective *** these patients,89 who received 125I radioactive seed implantation therapy were regarded as the research group(RG)and 95 patients who received surgical treatment were regarded as the control group(CG).The clinical efficacy,incidence of adverse reactions and changes in GDF11 and PD-1 before treatment(T0),2 wk after treatment(T1),4 wk after treatment(T2)and 6 wk after treatment(T3)were compared between the two *** The efficacy and recurrence rate in the RG were better than those in the CG(P11 and PD-1 between the two groups at T0 and T1,but these factors were lower in the RG than in the CG at T2 and T3(P11 and PD-1 had good predictive value for efficacy and recurrence(P1).CONCLUSION 125I radioactive seed implantation has clinical efficacy and can reduce the recurrence rate in patients with *** therapy has marked potential in clinical *** detection of GDF11 and PD-1 in patients during treatment showed good predictive value for treatment efficacy and recurrence in OC patients,and may be poten

关键词： 125I radioactive seeds Oral cancer Growth differentiation factor 11 programmed death receptor-1 Prognosis Recurrence

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Effect of microbiome group on immune checkpoint inhibitors in treatment of gastrointestinal tumors

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Chinese Journal of Cancer Research 2023年第3期35卷 252-265页

作者： Beibei Pei Xiaoyan Ma Na Wu Chen Wang Wenhui Yang Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Shanxi Medical University Taiyuan 030001China Department of Gastroenterology Shanxi Province Cancer Hospital/Shanxi Hospital Affliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affliated to Shanxi Medical UniversityTaiyuan 030013China

In recent years,immune checkpoint blockade(ICB)therapy has become an important treatment strategy for gastrointestinal tumors,however,it only benefits about 1/3 of *** the microbiome has been shown to play an important role in the human body for a long time,a growing number of studies are focusing on its relationship to ICB therapy in cancer,specifically how intestinal microbes affect the efficacy of immune checkpoint inhibitors(ICIs)therapy in *** this basis,probiotic interventions,fecal microbiota transplantation(FMT),dietary interventions,and other methods which improve or maintain the structure of the intestinal flora have attracted widespread *** article discusses the four aspects of the microbiome,ICB,combined treatment of gastrointestinal tumors,and regulation of gut ***,the discussion focuses on the contribution of probiotic intervention in improving the therapeutic effect of ICIs to prolong the survival time of patients and reduce the severity of immune-related adverse effects(irAEs).

关键词： Microbiome gastrointestinal tumors immune checkpoint blockade cancer immunotherapy programmed death receptor-1

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Drug resistance in cancer immunotherapy:new strategies to improve checkpoint inhibitor therapies

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Cancer Drug Resistance 2019年第4期2卷 980-993页

作者： Jesus Rodriguez-Pascual Angel Ayuso-Sacido Cristobal Belda-Iniesta Department of Clinical Oncology HM-CIOCCGrupo HM HospitalesMadrid 28050Spain Fundación de Investigación HM Hospitales(FiHM) Madrid 28015Spain Instituto de Salud Carlos III Madrid 28029Spain

Recent advances in pharmacological immune modulation against tumor cells has dramatically changed the paradigm of cancer *** inhibitor therapy is a form of cancer immunotherapy already in clinical setting but also under active basic and clinical ***,some patients are primary unresponsive or develop ulterior resistance to these family of *** review aims to update the basic molecular mechanism of resistance as well as the current strategies for checkpoint inhibitor selection in order to propose new approaches to individualize the use of these novel therapies.

关键词： Immunotherapy checkpoint inhibitors cytotoxic T-lymphocyte antigen 4 programmed death receptor-1 programmed death ligand-1

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