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Hepatocellular carcinoma:An analysis of the expression status of stress granules and their prognostic value

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2571-2591页

作者： Qing-Shuai Ren Qiu Sun Shu-Qin Cheng Li-Ming Du Ping-Xuan Guo Department of Cardiovascular Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina Department of Hepatobiliary Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjin 300000China Department of Traditional Chinese Medicine Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Anesthesiology Kailuan General HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is *** To analyze the impacts of stress granule(SG)genes on overall survival(OS),survival time,and prognosis in *** The combined The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC),GSE25097,and GSE36376 datasets were utilized to obtain genetic and clinical *** hub gene numbers and corresponding coefficients were determined using the Least absolute shrinkage and selection operator model approach,and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate Cox regression,*** prognostic model’s receiver operating characteristic(ROC)curve was produced and plotted utilizing the time ROC software *** models were constructed to predict the outcomes at 1,3,and 5-year OS prognostications with good prediction *** We identified seven SG genes(DDX1,DKC1,BICC1,HNRNPUL1,CNOT6,DYRK3,CCDC124)having a prognostic significance and developed a risk score *** findings of Kaplan-Meier analysis indicated that the group with a high risk exhibited significantly reduced OS in comparison with those of the low-risk group(P<0.001).The nomogram model’s findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC *** Ontology and Gene Set Enrichment Analysis suggested that these SGs might be involved in the cell cycle,RNA editing,and other biological *** Based on the impact of SG genes on HCC prognosis,in the future,it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.

关键词： Stress granule genes Hepatocellular carcinoma Gastrointestinal neoplasms Bioinformatics prognosis prognostic value

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prognostic value of ALP and LDH in Periampullary Carcinoma Patients Undergoing Surgery

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Current Medical Science 2022年第1期42卷 150-158页

作者： Chao DANG Yun-hua DENG Ren-yi QIN Department of Pancreatic-Biliary Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Dermatology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum *** alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)have been reported to have prognostic value in a variety of *** aim of this study was to investigate the effect of preoperative serum ALP and LDH levels on the prognosis of patients with periampullary carcinoma who underwent pancreatoduodenectomy(PD).

关键词： periampullary malignancy pancreatoduodenectomy alkaline phosphatase lactate dehydrogenase prognostic value

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EVALUATION OF THE prognostic value OF nm23 GENE EXPRESSION IN BREAST CANCER

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Chinese Journal of Cancer Research 2002年第2期14卷 88-92页

作者：刘红毛慧生傅西林方志沂冯玉梅范宇李树玲 Department of Breast Diseases Tianjin Medical University Cancer Hospital Tianjin Cancer Institute Tianjin 300060

Objective: To investigate the expression of nm23 gene and evaluate its prognostic value in breast cancer. Methods: nm23 expressions were detected in 101 breast cancer patients (group 1) by immunohistochemistry. RT-PCR and immunohistochemistry were used to measure expressions of nm23 gene in another 68 patients with breast cancer (group 2). Results: nm23 gene expression in group 1 was inversely associated with distant metastasis and lymph node metastasis (P<0.05). In 44 patients with negative lymph node, 9 cases progressed to distant metastasis, 7 of them (77.8%) showed low expression of nm23 gene (P<0.05). In 57 patients with positive lymph node, 24 our of 29 patients who had no distant metastasis (82.8%) expressed nm23 gene at high level (P<0.05). Meanwhile, there were 6 patients with distant metastasis in the group 2, all of thenm expressed nm23 gene mRNA at low level. Conclusion: The results showed that nm23 gene might play an independent role in predicting prognosis of breast cancer.

关键词： nm23 gene Breast cancer prognostic value

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Blood Calcium as a Protective Factor against Traumatic Fracture

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Journal of Biosciences and Medicines 2024年第3期12卷 328-336页

作者： Xin Zhang Quanquan Zhang Yinjun Luo Tao Feng Yue Hu Ying Li Wenjing Yu Linghan Guo Jinhua Wang Suchan Liao School of Basic Medical Sciences Youjiang Medical University for Nationalities Baise China Modern Industrial College of Biomedicine and Great Health Youjiang Medical University for Nationalities Baise China Department of Physiology School of Basic Medical Sciences Youjiang Medical University for Nationalities Baise China

Purpose: This study aims to investigate the predictive value of blood calcium in the prognosis of traumatic fracture. Methods: A retrospective experimental design was employed, 112 cases (52 non-fracture and 60 traumatic fracture) were randomly selected. The type of fracture complies with WHO-recommended (2019) diagnostic criteria for osteoporosis combined with fracture. The blood pressure (BP) was measured by OMRON’s HEM-7136 model electronic blood pressure monitor. Blood calcium (Ca2+), and blood phosphorus (P) values were measured using Colorimetric Roche kits on a Roche/Hitachi fully automated biochemical analyzer. Data collection and analysis followed. Results: Higher levels of age, systolic and diastolic blood pressures were found in the traumatic fracture group compared to the control group, whereas weight, height, and blood phosphorus did not differ significantly (P adjusting for age, systolic blood pressure, diastolic blood pressure, and blood phosphorus, binary logistic regression analysis revealed that blood calcium was a protective factor against traumatic fracture (β = -26.85, OR = 0.00, 95% CI = 0.00 -0.02, P = 0.022). Conclusion: The findings suggest that high and low blood calcium levels may serve as useful indicators in predicting the prognosis of fractures resulting from trauma.

关键词： Traumatic Fracture Fracture Biochemical Indicators Blood Calcium prognostic value

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Clinical implications and mechanism of histopathological growth pattern in colorectal cancer liver metastases

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World Journal of Gastroenterology 2022年第26期28卷 3101-3115页

作者： Bing-Tan Kong Qing-Sheng Fan Xiao-Min Wang Qing Zhang Gan-Lin Zhang Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China School of Graduates Beijing University of Chinese MedicineBeijing 100029China

Liver is the most common site of metastases of colorectal cancer,and liver metastases present with distinct histopathological growth patterns(HGPs),including desmoplastic,pushing and replacement HGPs and two rare *** is a miniature of tumor-host reaction and reflects tumor biology and pathological features as well as host immune *** studies have revealed the association of HGPs with carcinogenesis,angiogenesis,and clinical outcomes and indicates HGP functions as bond between microscopic characteristics and clinical *** findings make HGP a candidate marker in risk stratification and guiding treatment decision-making,and a target of imaging observation for patient *** note,it is crucial to determine the underlying mechanism shaping HGP,for instance,immune infiltration and extracellular matrix remodeling in desmoplastic HGP,and aggressive characteristics and special vascularization in replacement HGP(rHGP).We highlight the importance of aggressive features,vascularization,host immune and organ structure in formation of HGP,hence propose a novel"advance under camouflage"hypothesis to explain the formation of rHGP.

关键词： Colorectal cancer liver metastases Histopathological growth pattern Desmoplastic histopathological growth pattern Replacement histopathological growth pattern prognostic value Vessel co-option

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Spindle and Kinetochore-associated Family Genes are prognostic and Predictive Biomarkers in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 627-641页

作者： Chenhui Cai Ying Zhang Xu Hu Sizhen Yang Jiawen Ye Zihan Wei Tongwei Chu Department of Orthopedics Xinqiao HospitalThird Military Medical University(Army Medical University)ChongqingChina

Background and Aims:Hepatocellular carcinoma(HCC)is one of the most frequent malignant *** and kinetochore-associated(SKA)family genes are essential for the maintenance of the metaphase plate and spindle checkpoint silencing during *** studies have indicated that dysregulation of SKA family genes induces tumorigenesis,tumor progression,and chemoresistance via modulation of cell cycle and DNA ***,the differential transcription of SKAs in the context of HCC and its prognostic significance has not been ***:Bioinformatics analyses were performed using TCGA,ONCOMINE,HCCDB,Kaplan-Meier plotter,STRING,GEPIA ***-PCR,western blot,and functional as-says were utilized for in vitro ***:We found remarkable upregulation of transcripts of SKA family genes in HCC samples compared with normal liver samples on bioinformatics analyses and in vitro ***-action analysis and enrichment analysis showed that SKA family members were mainly related to microtubule motor activity,mitosis,and cell ***-infiltration analysis showed a correlation of all SKA family genes with various immune cell subsets,especially T helper 2(Th2)***-scriptional levels of SKA family members were positively as-sociated with histologic grade,T stage,andα-fetoprotein in HCC *** operating characteristic curve analy-sis demonstrated a strong predictive ability of SKA1/2/3 for *** expression of these SKAs was associated with unfavorable overall survival,progression-free survival,and disease-specific *** Cox proportional hazards regression analyses,SKA1 upregulation and pathological staging were independent predictors of overall survival and disease-specific survival of HCC ***,clinical tissue microarray validation and in vitro functional assays revealed SKA1 acts an important regulatory role in tumor malignant ***:SKA family members may potentially serve

关键词： Spindle and kinetochore-associated genes Liver hepatocellular carcinoma prognostic value Immune infiltration Bioinformatics analysis

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prognostic scores in primary biliary cholangitis patients with advanced disease

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1774-1783页

作者： Juan Feng Jia-Min Xu Hai-Yan Fu Nan Xie Wei-Min Bao Ying-Mei Tang Department of Gastroenterology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Yunnan Provincial First People’s HospitalKunming 650032Yunnan ProvinceChina

BACKGROUND Due to the chronic progressive disease characteristics of primary biliary cholangitis(PBC),patients with advanced PBC should not be *** prognostic score studies have focused on early stage *** To compare the prognostic value of various risk scores in advanced PBC to help PBC patients obtain more monitoring and *** This study considered patients diagnosed with PBC during hospitalization between 2015 and *** clinical stage was primarily middle and late,and patients usually took ursodeoxycholic acid(UDCA)after *** discriminatory performance of the scores was assessed with concordance statistics at baseline and after 1 year of UDCA *** follow-up was conducted to analyze the course and disease-associated *** follow-up deadline was December 31,*** compared the risk score indexes between those patients who reached a composite end point of death or liver transplantation(LT)and those who remained alive at the *** combined performance of prognostic scores in estimating the risk of death or LT after 1 year of UDCA treatment was assessed using Cox regression *** accuracy was evaluated by comparing predicted and actual survival through Kaplan-Meier *** We included 397 patients who were first diagnosed with PBC during hospitalization and received UDCA treatment;most disease stages were *** an average of 6.4±1.4 years of follow-up,82 patients had died,and 4 patients had undergone *** receiving UDCA treatment for 1 year,the score with the best discrimination performance was the Mayo,with a concordance statistic of 0.740(95%confidence interval:0.690-0.791).The albumin-bilirubin,GLOBE,and Mayo scores tended to overestimate transplant-free *** 7 years of calibration results showed that the Mayo score was the best *** The Mayo,GLOBE,UK-PBC,and ALBI scores demonstrated comparable discriminating performance for advanced stage

关键词： Primary biliary cholangitis prognostic value Liver transplantation Cholangitis Mayo score

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Impact of primary tumor volume and location on the prognosis of patients with locally recurrent nasopharyngeal carcinoma

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癌症 2015年第6期34卷 247-253页

作者： Yun-Ming Tian Wei-Wei Xiao Li Bai Xue-Wen Liu Chong Zhao Tai-Xiang Lu Fei Han Huizhou Municipal Central Hospital Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China 4. Col aborative Innovation Center of Cancer Medicine

Introduction:The properties of a tumor itself were considered the main factors determining the survival of patients with locally recurrent nasopharyngeal carcinoma(NPC)treated with intensity-modulated radiotherapy(IMRT).However,recurrent tumors were mainly evaluated by using the American Joint Committee on Cancer staging system,which was modeled on primary tumors and did not incorporate the tumor *** study aimed to investigate the prognostic values of the primary tumor location and tumor volume,and to determine whether evaluating these parameters could improve the current staging ***:Magnetic resonance(MR)images for 229 patients with locally recurrent NPC who underwent IMRT were analyzed ***:The skull base,parapharyngeal space,and intracranial cavity were the most common sites of *** was a difference in the survival between patients with T1 and T2 diseases(77.6%vs.50.0%,P38 cm3(48.7%vs.15.2%,P<0.01).Conclusions:A new staging system has been proposed,with T3 tumors being down-staged to T2 and with the tumor volume being incorporated into the staging,which may lead to an improved evaluation of these *** new system can be used to guide the treatment strategy for different risk groups of recurrent NPC.

关键词： Nasopharyngeal carcinoma Local recurrence prognostic value Tumor location Tumor volume

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Comprehensive analysis of TPX2 in Head and neck squamous cell carcinoma with prognostic values

Comprehensive analysis of TPX2 in Head and neck squamous cel...

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2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青...

作者： miaomiao chen wenjun cao Eye and ENT Hospital of Fu Dan University

Objective: Targeting protein for Xenopus kinesin-like protein 2（TPX2） is a microtubule-associated protein required for mitosis and spindle assembly. It has been revealed that TPX2 is overexpressed in various human cancers and promotes cancer progression, while its role in head and neck squamous cell carcinoma is unknown. We aimed to demonstrate the relationship between TPX2 and head and neck squamous cell ***: This study investigated the expression and roles of TPX2 in HNSC using Oncomine, The Cancer Genome Atlas, UALCAN, Human Protein Atlas, Clinical Proteomics Tumor Analysis Consortium,GeneMANIA, Tumor IMmune Estimation Resource, GEPIA ***: High mRNA and protein expression of TPX2 were found to be significantly associated with clinical cancer stages, nodal metastasis status, and patient’s gender in HNSC ***: Taken together, these results indicated that TPX2 could be a potential target in the development of anti-HNSC therapeutics and an efficient marker of the prognostic value of HNSC.

关键词： head and neck squamous cell carcinoma TPX2 public databases prognostic value comprehensive analysis

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An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Glioblastoma

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Journal of Biosciences and Medicines 2023年第8期11卷 95-113页

作者： Xiaobin Luo Department of Neurosurgery Zigong Fourth People’s Hospital Zigong China

To investigate the immunogenic Cell Death gene’s potential mechanism and prognostic value in glioblastoma. Information on GBM samples from The Cancer Genome Atlas database was downloaded, ICD genes were obtained, genotyping, integrated bioinformatics to verify the prognostic value of genotyping, and finally, prognostic model construction. Two subtypes associated with the ICD gene were obtained by consensus clustering, and the high ICD subtype (risk) group was associated with poor prognosis, high mutations in the PTEN gene, high stromal score, and high immune score. We also constructed a new classification system for GBM based on ICD characteristics. This study is the first to use immunogenic cell death genes for genotyping and successfully build a prognostic model.

关键词： Immunogenic Cell Death prognostic value Classification Immunotherapy Glioblastoma

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