Prognostic scores in primary biliary cholangitis patients with advanced disease

作     者：Juan Feng Jia-Min Xu Hai-Yan Fu Nan Xie Wei-Min Bao Ying-Mei Tang 

作者机构：Department of GastroenterologyThe Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General SurgeryYunnan Provincial First People’s HospitalKunming 650032Yunnan ProvinceChina 

出 版 物：《世界胃肠外科杂志:英文版(电子版)》 (World Journal of Gastrointestinal Surgery)

年 卷 期：2023年第15卷第8期

页      面：1774-1783页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Medicine Leading Talents of Yunnan Province,No.L-2019013 the Yunnan Wanren Project,No.YNWR-MY-2018-028 and Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University,No.2020ynlc010 

主　　题：Primary biliary cholangitis Prognostic value Liver transplantation Cholangitis Mayo score 

摘      要：BACKGROUND Due to the chronic progressive disease characteristics of primary biliary cholangitis(PBC),patients with advanced PBC should not be *** prognostic score studies have focused on early stage *** To compare the prognostic value of various risk scores in advanced PBC to help PBC patients obtain more monitoring and *** This study considered patients diagnosed with PBC during hospitalization between 2015 and *** clinical stage was primarily middle and late,and patients usually took ursodeoxycholic acid(UDCA)after *** discriminatory performance of the scores was assessed with concordance statistics at baseline and after 1 year of UDCA *** follow-up was conducted to analyze the course and disease-associated *** follow-up deadline was December 31,*** compared the risk score indexes between those patients who reached a composite end point of death or liver transplantation(LT)and those who remained alive at the *** combined performance of prognostic scores in estimating the risk of death or LT after 1 year of UDCA treatment was assessed using Cox regression *** accuracy was evaluated by comparing predicted and actual survival through Kaplan-Meier *** We included 397 patients who were first diagnosed with PBC during hospitalization and received UDCA treatment;most disease stages were *** an average of 6.4±1.4 years of follow-up,82 patients had died,and 4 patients had undergone *** receiving UDCA treatment for 1 year,the score with the best discrimination performance was the Mayo,with a concordance statistic of 0.740(95%confidence interval:0.690-0.791).The albumin-bilirubin,GLOBE,and Mayo scores tended to overestimate transplant-free *** 7 years of calibration results showed that the Mayo score was the best *** The Mayo,GLOBE,UK-PBC,and ALBI scores demonstrated comparable discriminating performance for advanced stage