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Clinical characteristics and outcome of primary hepatic neuroendocrine tumors after comprehensive therapy

World Journal of Gastrointestinal Oncology 2020年第9期12卷 1031-1043页

作者： Hao-Hao Wang Zhao-Chen Liu Gong Zhang Lu-Hao Li Lin Li Qing-Bo Meng Pei-Ju Wang Dong-Qi Shen Xiao-Wei Dang Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND primary hepatic neuroendocrine tumors(PHNETs),a group of neuroendocrine neoplasms,are extremely *** are only few case reports about PHNETs in the *** lack of large samples and multicenter research results in poor diagnostic and therapeutic *** To discuss the clinical characteristics,diagnosis,and treatment of PHNETs and risk factors related to *** We retrospectively analyzed the clinical data,imaging features,immunohistochemistry data,and treatment efficacy of 40 patients who were pathologically diagnosed with PHNETs and admitted to The First Affiliated Hospital of Zhengzhou University from January 1,2014 to November 15,***,survival analysis was performed to identify the risk factors for *** The main symptoms and signs included intermittent abdominal pain(19 patients,47.5%)and bloating(8 patients,20.0%).The positive rates of tested tumor markers were recorded as follows:Carbohydrate antigen 19-9(CA19-9)(6 patients,15.0%),CA72-4(3 patients,7.5%),carcinoembryonic antigen(7 patients,17.5%),and alpha-fetoprotein(6 patients,15.0%).Immunohistochemical staining results showed positivity for Syn in 38(97.4%)of 39 patients,for chromogranin A in 17(65.4%)of 26 patients,for CD56 in 35(94.6%)of 37 patients,for AE1/AE3 in 28(87.5%)of 32 patients,and for Ki-67 in all 40(100.0%)*** overall survival rate was significantly related to the tumor grade,AE1/AE3,and *** number,tumor size,metastasis,and treatment)and overall *** Higher grade,negative AE1/AE3,and higher Ki-67 are associated with a worse survival *** of treatment and other parameters have no significant influence on overall survival.

关键词： neuroendocrine tumors primary hepatic neuroendocrine tumors Diagnosis Survival analysis Tumor grade Treatment

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primary hepatic neuroendocrine tumor with a suspicious pulmonary nodule:A case report and literature review

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World Journal of Clinical Oncology 2025年第3期16卷 123-133页

作者： Hai-Yan Lv Mei-Xuan Liu Wen-Ting Hong Xia-Wei Li Department of Nursing The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Burns and Wound Care Center The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Nursing Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationCancer InstituteThe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Cancer Center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Harvard T.H.Chan School of Public Health Harvard UniversityCambridgeMA 02138United States

BACKGROUND primary hepatic neuroendocrine tumors(PHNETs)are extremely rare tumors originating from neuroendocrine *** to lack of neuroendocrine symptoms and specific radiographic characteristics,PHNETs are challenging to differentiate from other liver *** SUMMARY This case involved a 67-year-old male who was admitted with a discovered hepatic mass and a suspicious lung *** hepatic carcinoma was initially speculated based on the characteristic magnetic resonance imaging *** patient underwent a laparoscopic right partial hepatectomy,and subsequent immunohistochemical examination revealed a *** exclude other potential origins,a positron emission tomography-computed tomography scan and gastrointestinal endoscopy were performed,leading to a final diagnosis of *** we conducted a literature review using the PubMed database,identifying 99 articles and 317 cases related to *** characteristics,diagnostic methods,and treatment of PHNETs have been ***,we elaborate on the presumed origins,pathological grades,clinical features,diagnosed methods,and treatments associated with *** The diagnosis of PHNETs was primarily an exclusionary process.A definitive diagnosis of PHNETs relied mainly on immunohistochemical markers(chromogranin A,synaptophysin,and cluster of differentiation 56)and exclusion of primary foci in other *** surgery was the preferred treatment for early-stage tumors.

关键词： primary hepatic neuroendocrine tumors Pulmonary nodule neuroendocrine neoplasms Liver Surgical resection Case report

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