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Non-immune hydrops fetalis:Two case reports

World Journal of Clinical Cases 2021年第22期9卷 6531-6537页

作者： Marianna Maranto Valentina Cigna Emanuela Orlandi Gaspare Cucinella Clelia Lo Verso Vincenzo Duca Francesco Picciotto Fetal Medicine and Prenatal Diagnosis Unit Villa Sofia Cervello HospitalsPalermo 90146Italy Health Promotion Maternal and Infant Care UnitInternal Medicine and Medical Specialties“G.D’Alessandro”University of PalermoPalermo 90100Italy Neonatology and Neonatal Intensive Care Unit Civico Di Cristina Benfratelli HospitalPalermo 90100Italy Neonatology and Neonatal Intensive Care Unit Ingrassia HospitalPalermo 90100Italy

BACKGROUND Fetal hydrops is a serious condition difficult to manage,often with a poor prognosis,and it is characterized by the collection of fluid in the extravascular *** 1968,the most frequent cause was the maternal-fetal Rh ***,90%of the cases are non-immune hydrops *** fetal anatomic and functional disorders can cause non-immune hydrops fetalis and the pathogenesis is incompletely *** varies from viral infections to heart disease,chromosomal abnormalities,hematological and autoimmune *** SUMMARY A 38-year-old pregnant woman has neck lymphoadenomegaly,fever,cough,tonsillar plaques at 14 wk of amenorrhea and a rash with widespread *** 27.5 wk a fetal ultrasound shows signs of severe anemia and *** is performed with confirmation of severe fetal anemia and subsequent fetal *** karyotype is 46,XX,array-comparative genome hybridization(CGH)negative,and infectious tests are not *** the following days there is a progressive improvement of the indirect signs of fetal *** 33.6 wk,for relapse of severe fetal anemia,further fetal transfusions are necessary and an urgent cesarean section is *** the day 12 of life,for the detection of anemia,the newborn is subjected to transfusion of concentrated red blood cells and begins treatment with *** there is a normalization of blood chemistry values and the baby does not need new transfusions.A 29-year-old pregnant woman,with Sjogren's syndrome and positive Anti-Ro/SSA antibodies,is subjected to serial fetal ecocardio for branch *** 26.5 wk there is a finding of fetal *** disease tests on amniotic fluid are negative as well as quantitative fluorescent polymerase chain reaction,Array *** cordocentesis Hb is 1.3 mmol/L,consequently fetal transfusion is *** in this case,due to continuous episodes of relapse of fetal anemia with consequent transfusions,at 2

关键词： Cordocentesis Fetal anemia Fetal transfusion Hydrops fetalis preterm cesarean section Case report

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