Non-immune hydrops fetalis:Two case reports

作     者：Marianna Maranto Valentina Cigna Emanuela Orlandi Gaspare Cucinella Clelia Lo Verso Vincenzo Duca Francesco Picciotto 

作者机构：Fetal Medicine and Prenatal Diagnosis UnitVilla Sofia Cervello HospitalsPalermo 90146Italy Health PromotionMaternal and Infant Care UnitInternal Medicine and Medical Specialties“G.D’Alessandro”University of PalermoPalermo 90100Italy Neonatology and Neonatal Intensive Care UnitCivico Di Cristina Benfratelli HospitalPalermo 90100Italy Neonatology and Neonatal Intensive Care UnitIngrassia HospitalPalermo 90100Italy 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第22期

页      面：6531-6537页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Cordocentesis Fetal anemia Fetal transfusion Hydrops fetalis Preterm cesarean section Case report 

摘      要：BACKGROUND Fetal hydrops is a serious condition difficult to manage,often with a poor prognosis,and it is characterized by the collection of fluid in the extravascular *** 1968,the most frequent cause was the maternal-fetal Rh ***,90%of the cases are non-immune hydrops *** fetal anatomic and functional disorders can cause non-immune hydrops fetalis and the pathogenesis is incompletely *** varies from viral infections to heart disease,chromosomal abnormalities,hematological and autoimmune *** SUMMARY A 38-year-old pregnant woman has neck lymphoadenomegaly,fever,cough,tonsillar plaques at 14 wk of amenorrhea and a rash with widespread *** 27.5 wk a fetal ultrasound shows signs of severe anemia and *** is performed with confirmation of severe fetal anemia and subsequent fetal *** karyotype is 46,XX,array-comparative genome hybridization(CGH)negative,and infectious tests are not *** the following days there is a progressive improvement of the indirect signs of fetal *** 33.6 wk,for relapse of severe fetal anemia,further fetal transfusions are necessary and an urgent cesarean section is *** the day 12 of life,for the detection of anemia,the newborn is subjected to transfusion of concentrated red blood cells and begins treatment with *** there is a normalization of blood chemistry values and the baby does not need new transfusions.A 29-year-old pregnant woman,with Sjogren s syndrome and positive Anti-Ro/SSA antibodies,is subjected to serial fetal ecocardio for branch *** 26.5 wk there is a finding of fetal *** disease tests on amniotic fluid are negative as well as quantitative fluorescent polymerase chain reaction,Array *** cordocentesis Hb is 1.3 mmol/L,consequently fetal transfusion is *** in this case,due to continuous episodes of relapse of fetal anemia with consequent transfusions,at 2