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Hepatoblastoma with neonatal necrotizing enterocolitis:Two case reports

Cancer Innovation 2023年第6期2卷 532-536页

作者： Sidou He Xisi Wang Chao Duan Wen Zhao Chiyi Jiang Shihan Zhang Binglin Jian Wei Yang Tong Yu Libing Fu Huanmin Wang Xiaoli Ma Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Beijing Key Laboratory of Pediatric Hematology Oncology National Key Clinical Discipline of Pediatric OncologyKey Laboratory of Major Diseases in ChildrenMinistry of EducationBeijingChina Surgical Oncology Department Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Imaging Center Department Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Pathology Department Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina

We report two children with hepatoblastoma(HB)with a history of neonatal necrotizing enterocolitis(NEC).Case 1 was diagnosed with HB at 5 months of *** enlargement was found during the NEC operation at 3 months of age and then was clinically diagnosed by *** six chemotherapy courses,a partial hepatectomy was *** months after ceasing the chemotherapy,a chest computed tomography scan suggested that distant metastasis of the tumor should be considered,and the lesion was ***,9 months after the operation,alpha-fetoprotein concentrations were increased,and abdominal imaging showed a recurrence of the tumor in situ,resulting in a *** 2 was diagnosed with NEC shortly after birth and underwent an intestinal resection and anastomosis 1 month *** was diagnosed with HB at 3 years of *** was performed after five courses of *** was stopped after 10 courses,and alpha-fetoprotein concentrations were *** present,both children have survived and are in a healthy *** should be aware of the possibility of HB and a history of NEC in *** birth and low birth weight are common factors leading to the pathogenesis of HB and *** association between these two diseases requires further study。

关键词： hepatoblastoma LGR5 low birth weight neonatal necrotizing enterocolitis premature delivery

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Expression of hypoxia-inducible factor 1 alpha and oligodendrocyte lineage gene-1 in cultured brain slices after oxygen-glucose deprivation

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Neural Regeneration Research 2013年第4期8卷 328-337页

作者： Hong Cui Weijuan Han Lijun Yang Yanzhong Chang College of Life Science Hebei Normal University Department of Pediatrics Beijing Friendship HospitalCapital Medical University

Oligodendrocyte lineage gene-1 expressed in oligodendrocytes may trigger the repair of neuronal myelin impairment, and play a crucial role in myelin repair. Hypoxia-inducible factor la, a transcription factor, is of great significance in premature infants with hypoxic-ischemic brain damage There is little evidence of direct regulatory effects of hypoxia-inducible factor le on oligodendrocyte lineage gene-l. In this study, brain slices of Sprague-Dawley rats were cultured and subjected to oxygen-glucose deprivation. Then, slices were transfected with hypoxia-inducible factor la or oligodendrocyte lineage gene-1. The expression levels of hypoxia-inducible factor la and oligodendrocyte lineage gene-1 were significantly up-regulated in rat brains prior to transfection, as detected by immunohistochemical staining. Eight hours after transfection of slices with hypoxia-inducible factor la, oligodendrocyte lineage gene-1 expression was upregulated, and reached a peak 24 hours after transfection. Oligodendrocyte lineage gene-1 transfection induced no significant differences in hypoxia-inducible factor la levels in rat brain tissues with oxygen-glucose deprivation. These experimental findings indicate that hypoxia-inducible factor la can regulate oligodendrocyte lineage gene-1 expression in hypoxic brain tissue, thus repairing the neural impairment.

关键词： neural regeneration brain injury biological factors hypoxia-inducible factor la oligodendrocyte lineage gene-1 oxygen-glucose deprivation brain slice culture immunohistochemistry oligodendrocyte myelin repair premature delivery rat grants-supported paper photographs-containing paper neuroregeneration

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Evaluation of the Fetal Neuroprotection Protocol with Magnesium Sulphate in a University Hospital in Burkina Faso

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Open Journal of Obstetrics and Gynecology 2022年第10期12卷 1042-1055页

作者： Timongo Francoise Danielle Millogo-Traoré Oumarou Sawadogo S. W. Zongo-Kondé Training and Research Unit in Health Sciences Joseph Ki-Zerbo University Ouagadougou Burkina Faso Universitaire Hospitalier Yalgado Ouédraogo Ouagadougou Burkina Faso Regional Hospital Center Koudougou Burkina Faso

Introduction: Prematurity continues to stand as a major public health issue worldwide and more particularly for low incomes countries like Burkina Faso. Indeed, it is the main cause of high death rate and infant morbidity, neurologic deficiencies being one of them. Objective: From March 1st to September 30th, 2020, evaluate the fetal neuroprotection protocol using sulfate magnesium during births before thirty-three (33) weeks of amenorrhea at the University Health Centers (UHC) of Yalgado Ouedraogo and Bogodogo in Ouagadougou, Burkina Faso. Patients and Methods: It was a prospective cohort survey, exposed or unexposed. The exposed ones are from the UHC of Yalgado Ouedraogo, while the unexposed ones are from the UHC of Bogodogo. Analysis of the results showed 87 newborns from the exposed and 180 from the unexposed. The mortality rate, as well as neonatal neurologic complications, was higher with unexposed than with exposed. Although antenatal exposure to magnesium sulfate was not statistically associated with mortality and morbidity in newborns at a threshold of 0.05%, it has shown an overall good neurological prognosis in newborns exposed. Conclusion: A survey of a large sample of the population would be relevant in order to better assess the determinants of this influence. Proposition: In light of the results, the use of magnesium sulfate for neuroprotective purposes could be considered in our countries.

关键词： premature delivery Fetal Neuroprotection Sulfates Magnesium UHC of Yal-gado Ouedraogo UHC of Bogodogo Burkina Faso

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Effects of Atractylodes Macrocephala on the Cytomembrane Ca^(2+)-activated K^+ Currents in Cells of Human Pregnant Myometrial Smooth Muscles

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2008年第2期28卷 200-203页

作者：章小莉汪琳徐龙邹丽 Department of Gynecology and Obstetrics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430022China Department of Histology and Embryology the Medical College of Wuhan University Wuhan 430060China Department of Gastroenterology the People's Hospital of Wuhan University Wuhan 4300China

The study examined the inhibitory effect of Atractylodes macrocephala （AM） on the uterine contraction during premature delivery and explored its electrophysiological mechanism by studying the effects of AM on the Ca^2＋-activated K^＋ currents of pregnant human myometrial smooth muscle cells with or without the treatment with intedeukin-6. Single cells were acutely isolated from pregnant human myometrial smooth muscles. Whole-cell Ca^2＋-activated K^＋ currents were recorded by using an Axopatchl-D amplifier. The cells were divided into three groups： group A in which AM was added into perfusate, group B, in which interleukin-6 was added into perfusate） and group C in which AM was added into perfusate after addition of interleukin-6. IL-6 10 ng/mL inhibited BKca by 36.9%±13.7% as compared with control （P〈0.01）. AM at 2 mg/mL raised BKca by 36.7%±22.6% or 45.2%±13.7% with or without the treatment of IL-6, respectively （P〈0.01）. It is concluded that AM was able to enhance the BKca of pregnant human myometrial smooth muscle cells treated or untreated with interleukin-6 and its effect on the BKca IL-treated cells was stronger that its effect on BKca of untreated cells. Our results suggested that AM can help to maintain the membrane potentials and the resting status of pregnant human myometrial smooth muscle cells.

关键词： atractylodes macrocephala interleukin-6 patch clamp, Ca^2+-activated K^+ currents myometrial smooth muscle cells premature delivery

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