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Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia

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World Journal of Gastroenterology 2009年第4期15卷 489-495页

作者： Wei Wu Yun-Lin Wu Yan-Bo Zhu Qing Wei Yan Guo Zheng-Gang Zhu Yao-Zong Yuan Department of Pathology Shanghai Ruijin Hospital Affiliated to Sh'anghai JiaotongUniversity School of Medicine Shanghai 200025 China Department of Surgery Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200025 China

AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March *** sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations,endoscopic features,biopsy and surgical pathology of all patients were collected and *** data acquired were subjected to univariate and multivariate analysis. RESULTS:Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions,most of which(96.4%)were differentiated *** result of univariate analysis indicatedthat the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer(P<0.05),when high grade intraepithelial neoplasia was diagnosed by biopsy *** results of multivariate analysis revealed the size greater than 1.5 cm[odds ratio(OR)18.400,P<0.001]and the presence of 5-odd mm ulcer plaque or scar(OR 10.000,P=0.044)were associated with gastric ***,the sensitivity,specificity and negative predictive value of multivariate analysis for predicting"true high grade intraepithelial neoplasia" was 87.5%,89.3%and 96.2%,respectively. CONCLUSION:Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric *** may simplify patient work-up and save costs for patients and healthcare system.

关键词： Stomach neoplasm precancerous conditions Carcinoma in situ Endoscopy Gastrointestinal Path-ology

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Confocal laser endomicroscopy in the “in vivo” histological diagnosis of the gastrointestinal tract

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World Journal of Gastroenterology 2009年第46期15卷 5770-5775页

作者： Giovanni D De Palma Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgeryUniversity of Naples Federico ⅡSchool of Medicine

Recent technological advances in miniaturization have allowed for a confocal scanning microscope to be integrated into a conventional flexible endoscope,or into trans-endoscopic probes,a technique now known as confocal endomicroscopy or confocal laser *** newly-developed technology has enabled endoscopists to collect real-time in vivo histological images or "virtual biopsies" of the gastrointestinal mucosa during endoscopy,and has stimulated significant interest in the application of this technique in clinical *** review aims to evaluate the current data on the technical aspects and the utility of this new technology in clinical gastroenterology and its potential impact in the future,particularly in the screening or surveillance of gastrointestinal neoplasia.

关键词： Confocal microscopy Diagnostic imaging Gastrointestinal neoplasms precancerous conditions Endoscopy Virtual histology

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Tumor suppressor gene p16 and Rb expression in gastric cardia precancerouslesions from subjects at a high incidence area in northern China

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World Journal of Gastroenterology 2002年第3期8卷 423-425页

作者： ZhouY GaoSS 等 DepartmentofOncology theFirstAffiliatedHosptalZhengzhouUniversityZhengzhou450052 LaboratoryforCancerResarch CollegeofMedicineZhengzhouUniversity(FormerlyHenanMedcalUniversity)Zhe

AIM:To further understand the molecular basis for gastric cardia carcinogenesis and to provide etiological clues. METHODS: Endoscopic mucosa biopsy and histopathological examinations were made on 37 subjects from a high incidence area for both esophageal and gastric cardia carcinomas in northern China. All the biopsy samples were fixed in 850 ml. (-1)L alcohol and embedded in paraffin. Each block contained one piece of tissue and was serially section at 5 microm. Immunohistochemistry (ABC) was carried out on these gastric cardia samples to determine the alterations of p16 and Rb. RESULTS: Based on the histopathlogical examination there were 11 cases of chronic superficial gastritis, 12 cases of chronic atrophic gastritis and 14 cases of dysplasia. The immunostaining demonstrated different levels of unclear immunostaining of p16 and Rb in normal gastric cardia tissue and the tissues with different severity of lesions. With the lesions progressing, the positive immunostaining rates for p16 protein had a decreasing tendency. In contrast, the positive immunostaining rate for Rb protein had an increasing tendency. There was a significant negative relationship between the two parameters. Changes of p16 was CSG 11(100%), CAG 7(58%), DYS 4(29%) and changes of Rb was CSG 2(18%), CAG 8(67%) and DYS 12(86%), (P<0.05). CONCLUSION: The alterations of p16 and Rb protein may play a role in the early stages of gastric cardia carcinogenesis.

关键词： Genes, Retinoblastoma Genes, p16 China Gene Expression Humans precancerous conditions Research Support, Non-U.S. Gov't Risk Factors Stomach Neoplasms

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Possibility of non-invasive diagnosis of gastric mucosal precancerous changes

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World Journal of Gastroenterology 2004年第21期10卷 3146-3150页

作者： Victor D.Pasechnikov Sergey Z.Chukov Sergey M. Kotelevets Alexander N. Mostovov Varvara P. Mernova Maria B. Polyakova Department of Therapy Medical AcademyStavropolRussian Federation Department of Pathology Medical AcademyStavropolRussian Federation

AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric ***: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity, specificity and prognostic values of the ***: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17 or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic ***: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia, dysplasia or gastric cancer.

关键词： Helicobacter pylori Atrophy Biological Markers Biopsy Gastric Mucosa Gastrins Gastritis Helicobacter Infections Humans Immunoenzyme Techniques Mass Screening Pepsinogen A precancerous conditions Sensitivity and Specificity

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Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer

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World Journal of Gastroenterology 2001年第3期7卷 403-406页

作者： An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. Research Laboratory of Digestive Disease Huizhou Central People's Hospital No.41 Elingbei Road Huizhou 516001 Guangdong Province China.

INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 a... 详细信息

关键词： Apoptosis Female Humans Male Middle Aged precancerous conditions Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Research Support, Non-U.S. Gov't Stomach Neoplasms Tumor Suppressor Protein p53

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A STUDY ON CYCLOOXYGENASE -2 PROTEIN EXPRESSION IN ESOPHAGEAL CAICONOGENESIS

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Chinese Journal of Cancer Research 2001年第4期13卷 251-253页

作者：王立峰张伟王吾如王洪平韩双廷曲平刘义李茉刘伯齐林培中 Department of Pathology The First Hospital Harbin Medical University Harbin 150001 Cancer Institute Chinese Academy of Medical Sciences Beijing 100021 Department of Pathology The First Hospital Harbin Medical University Harbin 150001Cancer Institute Chinese Academy of Medical Sciences Beijing 100021

Objective: To investigate cyclooxygenase- 2(Cox-2) protein expression in esophageal cancer and precancerous lesions. Methods: One hundred twenty biopsy specimens from esophageal carcinoma and 113 from patients with esophageal premalingnant lesions, 27 from individuals with normal esophageal mucosa and 3 from Barrett’s esophagus were examined for Cox-2 protein expression by immunohistochemistry. Results: Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 protein expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barret’s esophageal tissues. Conclusion: The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.

关键词： Esophageal neoplasms precancerous conditions Cyclooxygenase-2

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Advances in the Researches on the Blocking Effect of Chinese Drugs on Tumors

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Journal of Traditional Chinese Medicine 2001年第3期21卷 236-240页

作者：吴万垠于尔辛刘煜 Department of Oncology the Second Hospital Affiliated to Guangzhou University of Traditional Chinese MedicineGuangzhou 510120 Oncology Hospital of Shanghai Medical University

Malignant tumors are caused by multiple carcinogenic factors undergoing several stages. The occurrence and development of tumors may be prevented and blocked if some effective interference factors are brought into play.1 At present, there are two main subjects for the researches, that is, blocking the precancerous lesions and blocking the develop-ment of tumors. The former focuses on the removing of carcinogenic factors and on the chemoprophylaxis of cancer, while the latter on the inhibition of cancer cell infiltration and cancerometastasis. These are summarized as follows.

关键词： Animals Antineoplastic Agents, Phytogenic Cell Transformation, Neoplastic Drugs, Chinese Herbal Humans Liver Neoplasms precancerous conditions

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Effects of San Qi on Gastric Secretion and Protective Factors of Gastric Mucosa in the Rat with precancerous Lesion of Stomach

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Journal of Traditional Chinese Medicine 2003年第3期23卷 220-224页

作者：石雪迎赵凤志戴欣董秀云方杰杨会敏王友京 Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine Beijing 100700 The Third Clinical Medical College of Beijing University

In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste,effects of San Qi (三七 Radix Notoginseng) on gastric secretion and protective factors of stomach were *** results indicated that gastric secretion,gastric mucosal blood flow (GMBF) and aminohexose content lowered significantly,and malondialdehyde (MDA) increased significantly (P<0.01) in the model group as compared with the normal group;after treatment with San Qi Powder for 12 weeks,both gastric secresion and GMBF increased,and MDA content decreased as compared with the negative control group (P<0.01),with no significant increase of aminohexose *** is suggested that San Qi (三七 Radix Notoginseng) may improve gastric secretion,and that increase of GMBF and antagonism against the lesion of oxygen free radicals are possibly one of its mechanisms.

关键词： Panax Animals Drugs, Chinese Herbal Gastric Mucosa Male Malondialdehyde precancerous conditions Rats Rats, Wistar Regional Blood Flow Stomach Neoplasms

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Telomerase activity analysis of esophageal carcinoma using microdissection-TRAP assay

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Chinese Medical Journal 2002年第9期115卷 1405-1408,156-157页

作者：李淳梁英锐吴名耀许丽艳蔡唯佳广东省汕头市汕头大学医学院病理教研室汕头515031 广东省佛山市第一人民医院病理科佛山528000

OBJECTIVES: To investigate telomerase activity in esophageal squamous cell carcinoma (SCC) and its preneoplasia lesions, and to study the relationships between telomerase activity and cancer differentiation, cancer invasiveness, and lymphatic metastasis. METHODS: Telomerase activity in esophageal SCC tissues, adjacent dysplasia tissues and normal epithelia from the surgical edge were assessed by microdissection-TRAP (telomeric repeat amplification protocol)-silver staining assay. RESULTS: Telomerase activity was detected in 37 (82.2%) of 45 esophageal tumors, 23 (79.3%) of 29 dysplasias, and 2 (5%) of 40 normal epithelia. There was a significant difference in activity between dysplasia and normal epithelium, as well as between tumor and normal epithelium. Twenty-six (92.9%) of 28 tumors with lymphatic metastasis had detectable telomerase activity compared to 11 (64.7%) of 17 non-lymphatic metastasis tumors. These relationships were statistically significant (P

关键词： Adult Aged Carcinoma, Squamous Cell Cell Differentiation Dissection Esophageal Neoplasms Female Humans Male Middle Aged Polymerase Chain Reaction precancerous conditions Repetitive Sequences, Nucleic Acid Telomerase Telomere

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Expression of telomerase genes in cancer development in atypical hyperplasia of the mammary duct

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Chinese Medical Journal 2002年第8期115卷 1221-1225,155页

作者：宋敏米小轶李柏林朱继江高英贤崔爽宋继谒中国医科大学基础医学院病理学教研室沈阳110001

OBJECTIVE: To investigate telomerase gene expression in precancerous mammary lesion, such as atypical ductal hyperplasia and breast cancer and to study the relationship between expression and malignant transformation. METHODS: Expression of human telomerase genes (hTR) and human reverse transcriptase gene (hTRT) in 76 cases of mammary tissue was evaluated using in situ hybridization and included 50 cases of mammary hyperplasia, 6 of which were benign hyperplasia, 9 were mild atypical hyperplasia, 12 were moderate atypical hyperplasia, 23 were severe atypical hyperplasia and 26 were mammary cancer. RESULTS: The expressions of hTR and hTRT mRNA were much weaker or negative in benign hyperplasia (16.6%, 0), weak to mild　moderate in atypical hyperplasia (22.2%, 11.1%, 33.3%, 25.0%), strong in severe atypical hyperplasia (60.9%, 52.1%), and significantly strong in mammary cancer (88.5%, 80.8%).The difference between mild-moderate atypical hyperplasia, invasive ductal carcinoma and severe atypical hyperplasia was significant (P 0.05). CONCLUSION: Telomerase genes (hTR and hTRT) expressions are related to the transformation of atypical hyperplasia. Activated telomerase may play a role in mammary cancer development.

关键词： Breast Breast Neoplasms DNA-Binding Proteins Female Gene Expression Humans precancerous conditions RNA RNA, Messenger Research Support, Non-U.S. Gov't Telomerase

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