Possibility of non-invasive diagnosis of gastric mucosal precancerous changes
Possibility of non-invasive diagnosis of gastric mucosal precancerous changes作者机构：Department of TherapyMedical AcademyStavropolRussian Federation Department of PathologyMedical AcademyStavropolRussian Federation
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2004年第10卷第21期
页 面：3146-3150页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Helicobacter pylori Atrophy Biological Markers Biopsy Gastric Mucosa Gastrins Gastritis Helicobacter Infections Humans Immunoenzyme Techniques Mass Screening Pepsinogen A Precancerous Conditions Sensitivity and Specificity
摘 要：AIM: To assess the possibility of non-invasive screening of atrophic chronic gastritis for preventing further development of gastric ***: One hundred and seventy-eight consecutive Helicobacter pylori ( H pylori)-positive dyspeptic patients after detection of serum levels of pepsinogen-1 (PG-1) and gastrin-17 (G-17) by enzyme immunoassay were proposed for endoscopy and histology. The serologic and morphologic results were compared with estimating the sensitivity, specificity and prognostic values of the ***: There was statistically significant reverse dependence between the grade of stomach mucosal antral or corpus atrophy and the proper decreasing of serum G17 or PG1 levels. The serologic method was quite sensitive in the diagnosis of non-atrophic and severe antral and corpus gastritis. Also, it was characterized by the high positive and negative prognostic ***: Detection of serum G-17 and PG1 levels can be offered as the screening tool for atrophic gastritis. The positive serologic results require further chromoendoscopy with mucosal biopsy, for revealing probable progressing of atrophic process with development of intestinal metaplasia, dysplasia or gastric cancer.
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