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Risk factors for postpartum posttraumatic stress disorder after emergency admission

World Journal of Emergency Medicine 2024年第2期15卷 121-125页

作者： Fengxia Du Jun Zha Yan Li Lichao Fang Shuyu Xia Youjia Yu Department of Obstetrics Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Anesthesiology the Second Affiliated Hospital of Wannan Medical CollegeWuhu 241000China Department of Anesthesiology Suzhou Xiangcheng People’s HospitalSuzhou 215131China Department of Emergency and Intensive Care Unit Suzhou Xiangcheng People’s HospitalSuzhou 215131China

BACKGROUND:Postpartum posttraumatic stress disorder(PTSD)can occur in women who give birth after emergency *** identification of risk factors for this condition is crucial for developing effective preventive *** retrospective study aimed to explore the incidence and risk factors for postpartum PTSD in women who give birth after emergency ***:Medical records of women who gave birth after emergency admission were collected between March 2021 and April *** patients’general conditions and perinatal clinical indicators were *** puerperae were divided into PTSD group and control group based on symptom occurrence at six weeks *** logistic regression analysis was performed to identify risk ***:A total of 276 puerperae were included,with a PTSD incidence of 20.3% at six weeks *** logistic regression analysis identified emergency cesarean section(odds ratio[OR]=2.102;95%confidence interval[CI]:1.114-3.966,P=0.022),admission to the emergency department after midnight(12:00 AM)(OR=2.245;95%CI:1.170-4.305,P<0.001),and cervical dilation(OR=3.203;95%CI:1.670–6.141,P=0.039)as independent risk factors for postpartum *** pump use(OR=0.500;95%CI:0.259–0.966,P=0.015)was found to be a protective factor against postpartum ***:Emergency cesarean section,admission to the emergency department after midnight,and cervical dilation were identified as independent risk factors for postpartum PTSD,while analgesic pump use was a protective *** findings provide insights for developing more effective preventive measures for women who give birth after emergency admission.

关键词： Risk factors posttraumatic stress disorder Emergency Delivery

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posttraumatic stress disorder after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 28-33页

作者： Shu-Guang Jin, Lu-Nan Yan, Bo Xiang, Bo Li, Tian-Fu Wen, Ji-Chun Zhao, Ming-Qing Xu and Jia-Ying Yang Department of Pediatric Surgery and Department of Liver and Vascular Surgery , West China Hospital, Sichuan University, Chengdu 610041, China Department of Pediatrie Surgery West China Hospital Sichuan University Chengdu 610041 Chengdu China Department of Liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Chengdu China

BACKGROUND: Liver transplantation can lead to the development of posttraumatic stress disorder (PTSD), but the risk factors associated with this progression are not well understood. To study this syndrome in adult liver transplant recipients, a cross-sectional investigation of 296 recipients at our hospital was carried out between January and June 2010. METHODS: Study participants completed two questionnaires [a PTSD self-rating scale (PTSD-SS) and a validated Chinese version of the Medical Outcomes Study Short Form-36 (SF-36)]. Clinical and demographic data were collected from the records of the Chinese Liver Transplant Registry and via questionnaires. RESULTS: The prevalence of full PTSD and partial PTSD (that met the criteria for 2 of the 3 symptom clusters) was 3.7% and 5.4%, respectively, for all transplant recipients. Significant differences between the recipients with no PTSD, partial PTSD, and full PTSD were found in all SF-36 domains except for physical functioning (P=0.466). In general, domain scores were the highest in the recipients who did not meet the criteria for PTSD and the lowest in the recipients who met the criteria for full PTSD. Greater severity of posttraumatic stress symptoms was correlated with poorer quality of life, especially in the bodily pain (P=0.004), social functioning (P=0.001), role-emotional (P=0.048), and mental health (P<0.001) domains. The model for end-stage liver disease (MELD) scores, complications, and educational status were identified by multiple regression analysis as risk factors for developing PTSD. CONCLUSIONS: PTSD occurred after liver transplantation and was significantly associated with decreased quality of life. Higher MELD scores and complications after transplantation were risk factors that contributed to PTSD, and higher education was a protective factor.

关键词： liver transplantation health-related quality of life posttraumatic stress disorder recipient

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Prevalence of posttraumatic stress disorder following acute coronary syndrome and clinical characteristics of patients referred to cardiac rehabilitation

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World Journal of Psychiatry 2023年第6期13卷 376-385页

作者： Ivana Sopek Merkaš Nenad Lakušić Zdenko Sonicki Barbara Koret Sandra Vuk Pisk Igor Filipčić Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Medical Statistics Epidemiologyand Medical InformaticsSchool of Public Health Andrija StamparSchool of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Psychiatry Clinic for Psychiatry“Sveti Ivan”Zagreb 10000Croatia Department of Psychiatry and Neurology Faculty of Dental Medicine and Health OsijekJ.J.Strossmayer University of OsijekOsijek 31000Croatia Department of Psychiatry and Psychological Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND Studies have demonstrated that patients who have experienced acute coronary syndrome(ACS)have an increased risk of developing posttraumatic stress disorder(PTSD)and experiencing worse survival outcomes than those who do not develop ***,the prevalence rates of PTSD following ACS vary widely across studies,and it is noteworthy that in most cases,the diagnosis of PTSD was based on self-report symptom questionnaires,rather than being established by ***,the individual characteristics of patients who develop PTSD after ACS can differ widely,making it difficult to identify any consistent patterns or predictors of the *** To investigate the prevalence of PTSD among a large sample of patients undergoing cardiac rehabilitation(CR)after ACS,as well as their characteristics in comparison to a control *** The participants of this study are patients who have experienced ACS with or without undergoing percutaneous coronary intervention and are enrolled in a 3-wk CR program at the largest CR center in Croatia,the Special Hospital for Medical Rehabilitation Krapinske *** recruitment for the study took place over the course of one year,from January 1,2022,to December 31,2022,with a total of 504 *** expected average follow-up period for patients included in the study is about 18 mo,and currently *** self-assessment questionnaire for PTSD criteria and clinical psychiatric interview,a group of patients with a PTSD diagnosis was *** the participants who do not have a PTSD diagnosis,patients who would match those with a PTSD diagnosis in terms of relevant clinical and medical stratification variables and during the same rehabilitation period were selected to enable comparability of the two *** A total of 507 patients who were enrolled in the CR program were approached to participate in the *** patients declined to participate in the *** screening PTSD

关键词： Cardiac rehabilitation Acute coronary syndrome posttraumatic stress disorder Psychiatric interview Multidisciplinary team Cardiac biomarkers

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Neurobiological mechanisms underlying delayed expression of posttraumatic stress disorder:A scoping review

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World Journal of Psychiatry 2022年第1期12卷 151-168页

作者： Geert E Smid Jonna Lind Jens Peter Bonde ARQ Centrum'45 ARQ National Psychotrauma CentreDiemen 1112XENetherlands Department of Humanist Chaplaincy Studies University of Humanistic StudiesUtrecht 3512 HDNetherlands ARQ Centre of Excellence on War Persecution and ViolenceARQ National Psychotrauma CentreDiemen 1112XENetherlands Department of Occupational and Environmental Medicine Frederiksberg and Bispebjerg HospitalCopenhagen 2400Denmark Department of Public Health University of CopenhagenCopenhagen 1014Denmark

BACKGROUND The capacity of posttraumatic stress disorder(PTSD)to occur with delayed onset has been documented in several systematic reviews and *** models of PTSD may provide insight into the mechanisms underlying the progressive increase in PTSD symptoms over time as well as into occasional occurrences of long-delayed PTSD with few prodromal *** To obtain an overview of key concepts explaining and types of evidence supporting neurobiological underpinnings of delayed *** A scoping review of studies reporting neurobiological findings relevant to delayed PTSD was performed,which included 38 studies in the qualitative *** Neurobiological mechanisms underlying PTSD symptoms,onset,and course involve several interconnected *** mechanisms involve the neurocircuitry of fear,comprising several structures,such as the hippocampus,amygdala,and prefrontal cortex,that are amenable to time-dependent increases in activity through sensitization and *** network models explain generalization of the fear *** mechanisms consist of autonomic nervous system and hypothalamic-pituitary-adrenocortical axis responses,both of which may be involved in sensitization to *** mechanisms are characterized by immune activation,which is sometimes due to the effects of traumatic brain ***,neurobehavioral/contextual mechanisms involve the effects of intervening stressors and mental and physical disorder comorbidities,and these may be particularly relevant in cases of long-delayed *** Thus,delayed PTSD may result from multiple underlying neurobiological mechanisms that may influence the likelihood of developing prodromal symptoms preceding the onset of full-blown PTSD.

关键词： posttraumatic stress disorder Delayed expression Sensitization Neurobiology Neuroendocrine Neuroinflammatory

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Psychological trauma,posttraumatic stress disorder and traumarelated depression:A mini-review

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World Journal of Psychiatry 2023年第6期13卷 331-339页

作者： Shi-Kai Wang Min Feng Yu Fang Liang Lv Gui-Lan Sun Sheng-Liang Yang Ping Guo Shan-Fei Cheng Min-Cai Qian Huan-Xin Chen Department of Psychiatry The Third People’s Hospital Affiliated to Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Department of Neurosis and Psychosomatic Diseases The Third People’s Hospital Affiliated to Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Department of Key Laboratory The Third People’s Hospital Affiliated to Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

There are various types of traumatic stimuli,such as catastrophic events like wars,natural calamities like earthquakes,and personal trauma from physical and psychological neglect or abuse and sexual *** events can be divided into type I and type II trauma,and their impacts on individuals depend not only on the severity and duration of the traumas but also on individuals’self-evaluation of the traumatic *** stress reactions to trauma include posttraumatic stress disorder(PTSD),complex PTSD and trauma-related ***-related depression is a reactive depression with unclear pathology,and depression occurring due to trauma in the childhood has gained increasing attention,because it has persisted for a long time and does not respond to conventional antidepressants but shows good or partial response to psychotherapy,which is similar to the pattern observed for *** trauma-related depression is associated with high risk of suicide and is chronic with a propensity to relapse,it is necessary to explore its pathogenesis and therapeutic strategy.

关键词： Psychological trauma Trauma-related depression Reactive depression posttraumatic stress disorder Antidepressant Psychotherapy

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Chronic pain, posttraumatic stress disorder, and opioid intake: A systematic review

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World Journal of Clinical Cases 2019年第24期7卷 4254-4269页

作者： Alicia E López-Martínez ángela Reyes-Pérez Elena Rocío Serrano-Ibá?ez Rosa Esteve Carmen Ramírez-Maestre Facultad de Psicología Instituto de Investigaciones Biomédicas (IBIMA)Universidad de Málaga

BACKGROUND The literature suggests that there is a high degree of co-occurrence between chronic pain and posttraumatic stress disorder(PTSD). An association has been found between PTSD and substance abuse. PTSD is a severe disorder that should be taken into account when opioids are prescribed. It has been found that the prevalence of opioid use disorder(OUD) in chronic pain patients is higher among those with PTSD than those without this *** To perform a systematic review on the association between PTSD, chronic noncancer pain(CNCP), and opioid intake(i.e., prescription, misuse, and abuse).METHODS We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Patient, Intervention,Comparator, and Outcomes(PICOS) criteria were formulated a priori in the protocol of the systematic review. A search was conducted of the PROSPERO database. In March 2019, searches were also conducted of 5 other databases:Pub Med, MEDLINE, Psyc INFO, Web of Science, and PILOTS. The Scottish Intercollegiate Guidelines Network checklist for cohort studies was used to assess the selected studies for their methodological quality and risk of bias. Each study was evaluated according to its internal validity, participant sampling,confounding variables, and the statistical *** A total of 151 potentially eligible studies were identified of which 17 were retained for analysis. Only 10 met the selection criteria. All the studies were published between 2008 and 2018 and were conducted in the United States. The eligible studies included a total of 1622785 unique participants. Of these, 196516 had comorbid CNCP and PTSD and were consuming opiates. The participants had a cross-study mean age of 35.2 years. The majority of participants were men(81.6%). The most common chronic pain condition was musculoskeletal pain:back pain(47.14% across studies;range: 16%-60.6%), arthritis and joint pain(31.1%;range: 18%-67.5%), and

关键词： posttraumatic stress disorder Chronic pain Opioid prescription Opioid misuse Opioid abuse

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White Matter Changes in posttraumatic stress disorder Following Mild Traumatic Brain Injury： A Prospective Longitudinal Diffusion Tensor Imaging Study

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Chinese Medical Journal 2016年第9期129卷 1091-1099页

作者： Li Li Gang Sun Kai Liu Min Li BO Li Shao-Wen Qian Li-Li Yu Institute of Postgraduates The Second Military Medical University Shanghai 200032 China Department of Medical Imaging Jinan Military General Hospital Jinan Shandong 250031 China Department of Statistics~ Ji'nan Military General Hospitail Jinan Sh'andong 2500311 China

Background： The ability to predict posttraumatic stress disorder （PTSD） is a critical issue in the management of patients with mild traumatic brain injury （mTBI）, as early medical and rehabilitative interventions may reduce the risks of long-term cognitive changes. The aim of the present study was to investigate how diffusion tensor imaging （DTI） metrics changed in the transition from acute to chronic phases in patients with mTBI and whether the alteration relates to the development of PTSD. Methods： Forty-three patients with mTBI and 22 healthy volunteers were investigated. The patients were divided into two groups： successful recovery （SR, n = 22） and poor recovery （PR, n = 21）, based on neurocognitive evaluation at 1 or 6 months after injury. All patients underwent magnetic resonance imaging investigation at acute （within 3 days）, subacute （10-20 days）, and chronic （1-6 months） phases after injury. Group differences of fractional anisotropy （FA） and mean diffusivity （MD） were analyzed using tract-based spatial statistics （TBSS）. The accuracy of DTI metrics for classifying PTSD was estimated using Bayesian discrimination analysis. Results： TBSS showed white matter （WM） abnormalities in various brain regions. In the acute phase, FA values were higher for PR and SR patients than controls （all P 〈 0.05）. In subacute phase, PR patients have higher mean MD than SR and controls （all P 〈 0.05）. In the chronic phase, lower FA and higher MD were observed in PR compared with both SR and control groups （all P 〈 0.05）. PR and SR groups could be discriminated with a sensitivity of 73%, specificity of 78%, and accuracy of 75.56%, in terms of MD value in subacute phase. Conclusions： Patients with mTBI have multiple abnormalities in various WM regions. DTI metrics change over time and provide a potential indicator at subacute stage for PTSD following mTBI.

关键词： Diffusion Tensor Imaging Mild Traumatic Brain Injury posttraumatic stress disorder Tract-based Spatial Statistics

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Citation analysis of meta-analysis articles on posttraumatic stress disorder

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Chinese Medical Journal 2011年第7期124卷 1088-1093页

作者： LIAO Xi-ming CHEN Ping-yan Department of Biostatistics School of Public Health and Tropical Medicine Southern Medical University Guangzhou Guangdong 510515 China

Background In the past two decades enormously scientific researches on posttraumatic stress disorder （PTSD） have been undertaken and many related meta-analyses have been published. Citation analysis was used to get comprehensive perspectives of meta-analysis articles （MA articles） on PTSD for the purpose of facilitating the researchers, ohvsicians and Policy-makers to understand the PTSD.

关键词： meta-analysis posttraumatic stress disorder bibliometric analysis

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Primary prevention of posttraumatic stress disorder: drugs and implications

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Military Medical Research 2015年第3期3卷 156-162页

作者： Joachim C Burbiel Fraunhofer Institute for Technological Trend Analysis INT Appelsgarten 2 53879 Euskirchen Germany

Because posttraumatic stress disorder(PTSD) is a highly debilitating condition, prevention is an important research topic. This article reviews possible prevention approaches that involve the administration of drugs before the traumatic event takes place. The considered approaches include drugs that address the sympathetic nervous system, drugs interfere with the hypothalamic-pituitary-adrenal(HPA) axis, narcotics and other psychoactive drugs, as well as modulators of protein synthesis. Furthermore, some thoughts on potential ethical implications of the use of drugs for the primary prevention of PTDS are presented. While there are many barriers to overcome in this field of study, this paper concludes with a call for additional research, as there are currently no approaches that are well-suited for regular daily use.

关键词： posttraumatic stress disorder Prevention Pre-treatment Propranolol Prazosin Ketamine Morphine Anisomycin Osanetant

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Self-compassion and resilience mediate the relationship between childhood exposure to domestic violence and posttraumatic growth/stress disorder during COVID-19 pandemic

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World Journal of Psychiatry 2021年第11期11卷 1106-1115页

作者： Xin-Li Chi Qiao-Min Huang Xiao-Feng Liu Liu-Yue Huang Meng-Jian Hu Zhi-Jing Chen Can Jiao Brendon Stubbs M Mahbub Hossain Li-Ye Zou Institute of KEEP Collaborative Innovation School of PsychologyShenzhen UniversityShenzhen 518060Guangdong ProvinceChina Guangdong Polytechnic Foshan 528041Guangdong ProvinceChina Longhua No.2 Experimental School Affiliated Hongchuang Kindergarten Shenzhen 518100Guangdong ProvinceChina Physiotherapy Department South London&Maudsley NHS Fdn TrustLondon WC2R 2LSUnited Kingdom Institute of Psychiatry Psychology and NeuroscienceKing's College LondonLondon WC2R 2LSUnited Kingdom School of Public Health Texas A&M UniversityTexasTX 77843United States Exercise Psychophysiology Laboratory Institute of KEEP Collaborative InnovationSchool of PsychologyShenzhen UniversityShenzhen 518060Guangdong ProvinceChina

BACKGROUND Studies have indicated that childhood exposure to domestic violence is a common factor in posttraumatic growth(PTG)and posttraumatic stress disorder(PTSD),but it is unclear whether PTG and PTSD share a common/different underlying *** To explore the common/different underlying mechanism of PTG and *** Between February 12 and 17,2020,a nationwide cross-sectional online survey was conducted in China among 2038 university students,and a self-administered questionnaire was used for the data *** data included demographic characteristics,such as age,gender,and subjective social economic status,and childhood exposure to domestic violence scale that was selected from the Chinese version of revised Adverse Childhood Experiences Question,Self-compassion Scale,Connor–Davidson Resilience Scale,posttraumatic Growth Inventory,and the Abbreviated PTSD Checklist-Civilian version.A structural equation model was used to test the *** Exposure to domestic violence was significantly associated with PTG and PTSD via a 1-step indirect path of self-compassion(PTG:β=-0.023,95%CI:-0.44 to-0.007;PTSD:β=0.008,95%CI:0.002,0.014)and via a 2-step indirect path from self-compassion to resilience(PTG:β=-0.008,95%CI:-0.018 to-0.002;PTSD:β=0.013,95%CI:0.004-0.024).However,resilience did not mediate the relationship between exposure to domestic violence and PTG and *** PTG and PTSD are common results of childhood exposure to domestic violence,which may be influenced by self-compassion and resilience.

关键词： Self-compassion Resilience Domestic violence posttraumatic growth posttraumatic stress disorder COVID-19

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