Posttraumatic stress disorder after liver transplantation

作     者：Shu-Guang Jin, Lu-Nan Yan, Bo Xiang, Bo Li, Tian-Fu Wen, Ji-Chun Zhao, Ming-Qing Xu and Jia-Ying Yang Department of Pediatric Surgery and Department of Liver and Vascular Surgery , West China Hospital, Sichuan University, Chengdu 610041, China 

作者机构：Department of Pediatrie Surgery West China Hospital Sichuan University Chengdu 610041 Chengdu China Department of Liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Chengdu China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2012年第11卷第1期

页      面：28-33页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by a grant from the National Science and Technology Key Projects of China (2008ZX10002-026) 

主　　题：liver transplantation health-related quality of life posttraumatic stress disorder recipient 

摘      要：BACKGROUND: Liver transplantation can lead to the development of posttraumatic stress disorder (PTSD), but the risk factors associated with this progression are not well understood. To study this syndrome in adult liver transplant recipients, a cross-sectional investigation of 296 recipients at our hospital was carried out between January and June 2010. METHODS: Study participants completed two questionnaires [a PTSD self-rating scale (PTSD-SS) and a validated Chinese version of the Medical Outcomes Study Short Form-36 (SF-36)]. Clinical and demographic data were collected from the records of the Chinese Liver Transplant Registry and via questionnaires. RESULTS: The prevalence of full PTSD and partial PTSD (that met the criteria for 2 of the 3 symptom clusters) was 3.7% and 5.4%, respectively, for all transplant recipients. Significant differences between the recipients with no PTSD, partial PTSD, and full PTSD were found in all SF-36 domains except for physical functioning (P=0.466). In general, domain scores were the highest in the recipients who did not meet the criteria for PTSD and the lowest in the recipients who met the criteria for full PTSD. Greater severity of posttraumatic stress symptoms was correlated with poorer quality of life, especially in the bodily pain (P=0.004), social functioning (P=0.001), role-emotional (P=0.048), and mental health (P0.001) domains. The model for end-stage liver disease (MELD) scores, complications, and educational status were identified by multiple regression analysis as risk factors for developing PTSD. CONCLUSIONS: PTSD occurred after liver transplantation and was significantly associated with decreased quality of life. Higher MELD scores and complications after transplantation were risk factors that contributed to PTSD, and higher education was a protective factor.