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Nutraceutical health benefit and safety utility of portulaca oleracea: A review focus on neuroendocrine function

Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 83-95页

作者： Oyowvi Mega Obukohwo Department of Physiology Adeleke UniversityEdeOsun State PMB 250Nigeria

Background:portulaca oleracea L.,a traditional medicine with bioactive compounds like flavonoids and omega-3 fatty acids,has gained interest in its neuroendocrine and toxicological ***:The aim of this review is to provide a comprehensive summary of the current knowledge on the neuroendocrine and toxicological activities of portulaca *** review also highlights the potential mechanisms of action of these ***:A literature search was conducted using various databases such as PubMed,ScienceDirect,and Google *** such as’portulaca oleracea’,’purslane’,’neuroendocrine activity’,and’toxicological activity’were used to identify relevant *** studies published in English were included in this ***:portulaca oleracea has been found to improve testicular and cognitive function as well as memory in animal models of Alzheimer’s disease and cerebral ischemia due to its antioxidant,anti-inflammatory properties,anti-anxiety and anti-depressant *** the other hand,portulaca oleracea has also been reported to possess toxicological *** have shown that high doses of portulaca oleracea extract can cause liver and kidney damage in animal *** toxic effects of portulaca oleracea are thought to be due to the presence of oxalates and nitrates in the ***,these toxic effects have not been observed in human studies,where portulaca oleracea was found to be safe for ***:In conclusion,portulaca oleracea,a medicinal plant with potential health benefits,has neuroendocrine effects like neuroprotective,anxiolytic,and anti-depressant ***,high doses should be used cautiously due to potential toxicological effects.

关键词： portulaca oleracea Purslane Neuronal activity Endocrine activity Toxicological activity

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portulaca oleracea Leaf Aqueous Lyophilized Extract Reduces Hyperglycemia and Improves Antioxidant Status of Red Blood Cells and Liver in Streptozotocin-lnduced Diabetic Wistar Rats

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Journal of Pharmacy and Pharmacology 2017年第3期5卷 139-148页

作者： Guenzet Akila Krouf Djamil Berzou Sadia Laboratoire de Nutrition Clinique et Metabolique Departement de Biologie Faculte des Sciences de la Nature et de la VieUniversitd d'Oran Oran 31000 Alg~rie

The aim of this study was to investigate the antihyperglycemic and antioxidant effects of Po （portulaca oleracea） lyophilised aqueous extract in diabetic male Wistar rats. Diabetes was induced intraperitonially by a single injection of STZ （streptozotocin）（60 mg/kg bw （body weight））. Twenty diabetic rats, weighing 263 ± 5 g, were divided into two groups fed a casein diet supplemented or not with Po extract （1 g/kg bw）, for four weeks. Control group （n = 6） received 0.23-0.25 mL of citrate buffer and was fed a standard diet during the experiment. The study was carried out at Oran University, Algeria and the entire experiments lasted from September 2011 to July 2012. Blood was obtained from the abdominal aorta of rats after fasting overnight and standard methods were used for the extraction of spices, determination of glycemia, insulinemia, lipid peroxidation and antioxidant enzymes activities. portulaca oleracea treated compared to untreated rats, glycemia and HbAIc values were respectively 2.8- and 1.7-fold lower. TBARS （thiobarbituric acid reactive substances） concentrations were reduced in RBC （red blood cells）（-54%） and plasma （-65%）. Moreover, in liver and kidney, TBARS values were respectively 1.8- and 2-fold lower. SOD （superoxide dismutase） and GSH-Px （glutathione peroxidase） activities were increased respectively by ＋38% and ＋85%, in liver. GSSG-Red （glutathione reductase） activity was 1.9-fold higher in kidney, while CAT （catalase） was improved in kidney （＋48%）. In RBCs, SOD, GSH-Px, GSSH-Red and CAT activities were increased by 31%, 42%, 56% and ＋50%, respectively. These data have cast a new light on the actions of portulaca oleracea and its antioxidant potential benefits in preventing diabetes and its complications.

关键词： portulaca oleracea rats diabetes streptozotocin antioxidative enzymes TBARS.

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Chemical constituents from portulaca oleracea and their bioactivity

Chemical constituents from Portulaca oleracea and their bioa...

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中国化学会第十一届全国天然有机化学学术会议

作者： Tianyun Jin Tao Shen Mingxing Zhou Ailing Li Da Feng Bolun Zheng Jie Gong Jiawei Sun Lingyu Li Lan Xiang School of Pharmaceutical Sciences Shandong University

The aim of this experiment is to intensively study the chemical constituents,especially organic acids from a medicinal plant portulaca oleracea L.,and screen their anti-inflammatory *** compounds（Fig.1） were isolated and identified based on spectroscopic methods,as succinic acid（1）,mono-methyl succinate（2）,L-malic acid（3）,L-1-methyl malate（4）,L-4-methylmalate（5）,L-dimethyl malate（6）,L-6-ethyl citrate（7）,L-1-methyl citrate（8）,L-1,5-dimethyl citrate（9）,4-hydroxy-5-methylfuran-3-carboxylic acid（10）,5-hydroxymethyl-furoic acid（11）,stearic acid（12）,L-pyroglutamic acid（13）,cyclo-（tyrosine-leucine）（14）,L-leucine（15）,（-）-dehydrovomifoliol（16）,（-）-epiloliolide（17）,3,4-dihydroxyphenyiethanol（18）,succinimide（19）,and uracil（20）.Among them,fourteen compounds（2,4-8,10,11,13-18） were firstly isolated from *** 18（12.5μM） exhibited potent anti-inflammatory effect in lipopolysaccharide（LPS）-induced macrophage cells（RAW264.7） by reducing NO production.

关键词： portulaca oleracea Chemical constituents Anti-inflammatory

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Phenolic Compounds from portulaca oleracea and Their Cytotoxic Activity

Phenolic Compounds from Portulaca oleracea and Their Cytotox...

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多学科交叉，产学研联合，实现西部药用植物资源的可持续利用——第十届全国药用植物及植物药学术研讨会

作者： Jian Yan~1,Zhong-Yu Zhou~1,Mei Zhang~1,Jing Wang~1,Hao-Fu Dai~2 and Jian-Wen Tan~(1*) 1 Key Laboratory of Plant Resources Conservation and Sustainable Utilization,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650, 2 State Key Laboratory of Tropical Crops Biotechnology,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agriculture Sciences, Haikou 571101,

Five phenolic compounds(1-5)including four new homoisoflavanonoids,named portulacanones A-D(1-4),were isolated from the whole plants of portulaca *** structures were identified as 2′-hydroxy-5,7-dimethoxy-3-benzyl-chroman-4-one(1),2′-hydroxy-5,6,7-trimethoxy- 3-benzyl-chroman-4-one(2),5,2′-dihydroxy-6,7-dimethoxy-3-benzyl-chroman-4-one(3),5,2′- dihydroxy-7-methoxy-3-benzylidene-chroman-4-one(4)and 2,2′-dihydroxy-4′,6′-dimethoxy

关键词： portulaca oleracea Homoisoflavonoid portulacanone Cytotoxic activity

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Chemical composition and biological activities of portulaca oleracea

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亚洲传统医药(英文) 2023年第4期18卷 173-202页

作者： Haonan Yu Yi’an Shi Yibo Wang Yunpeng Yang Ying Li Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

portulaca oleracea(***)is a traditional Chinese herbal that has the effects of soothing the liver and clearing collaterals,strengthening the spleen and stomach,moistening the intestines and *** the development of the pharmaceutical industry,the medicinal value of *** is becoming increasingly *** is commonly used in clinical practice for clearing heat and detoxifying,inhibiting bacteria,preventing and treating diseases such as hypertension,coronary heart disease,and cerebral infarction,indicating its broad application *** study reviews the chemical components and pharmacological activities of *** in recent decades.

关键词： portulaca oleracea chemical composition biological activity

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