Chemical constituents from Portulaca oleracea and their bioactivity
作者单位：School of Pharmaceutical SciencesShandong University
会议名称：《中国化学会第十一届全国天然有机化学学术会议》
会议日期：2016年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学]
基 金：supports from National Natural Science Foundation of China(No.81073005) Science and Technology Development Program of Shandong Province(2014GSF119007) Major Project of Science and Technology of Shandong Province(2015ZDJS04001) Young Scholars Program of Shandong University(YSPSDU2015WLJH50)
关 键 词：Portulaca oleracea Chemical constituents Anti-inflammatory
摘 要：The aim of this experiment is to intensively study the chemical constituents,especially organic acids from a medicinal plant Portulaca oleracea L.,and screen their anti-inflammatory *** compounds（Fig.1） were isolated and identified based on spectroscopic methods,as succinic acid（1）,mono-methyl succinate（2）,L-malic acid（3）,L-1-methyl malate（4）,L-4-methylmalate（5）,L-dimethyl malate（6）,L-6-ethyl citrate（7）,L-1-methyl citrate（8）,L-1,5-dimethyl citrate（9）,4-hydroxy-5-methylfuran-3-carboxylic acid（10）,5-hydroxymethyl-furoic acid（11）,stearic acid（12）,L-pyroglutamic acid（13）,cyclo-（tyrosine-leucine）（14）,L-leucine（15）,（-）-dehydrovomifoliol（16）,（-）-epiloliolide（17）,3,4-dihydroxyphenyiethanol（18）,succinimide（19）,and uracil（20）.Among them,fourteen compounds（2,4-8,10,11,13-18） were firstly isolated from *** 18（12.5μM） exhibited potent anti-inflammatory effect in lipopolysaccharide（LPS）-induced macrophage cells（RAW264.7） by reducing NO production.