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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM Polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM Polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine Polysaccharides gut microbiota short-chain fatty acids lipoPolysaccharides gut-organaxis synergistic actions

Neuroprotective effects of naturally sourced bioactive Polysaccharides: an update

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Neural Regeneration Research 2022年第9期17卷 1907-1912页

作者： Xiao-Lan Xu Song Li Rong Zhang Wei-Dong Le Department of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Liaoning Provincial Center for Clinical Research on Neurological Diseases The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina

Polysaccharides are macromolecular complexes that have various biological activities.In vivo and in vitro studies have shown that Polysaccharides play neuroprotective roles through multiple mechanisms;consequently,they have potential in the prevention and treatment of neurodegenerative diseases.This paper summarizes related research published during 2015-2020 and reviews advances in the understanding of the neuroprotective effects of bioactive Polysaccharides.This review focuses on 15 bioactive Polysaccharides from plants and fungi that have neuroprotective properties against oxidative stress,apoptosis,neuroinflammation,and excitatory amino acid toxicity mainly through the regulation of nuclear factor kappa-B,phosphatidylinositol-3-kinase/protein kinase B,mitogen-activated protein kinase,nuclear factor-E2-related factor 2/hemeoxygenase-1,c-jun N-terminal kinase,protein kinase B-mammalian target of rapamycin,and reactive oxygen species-nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3 signaling pathways.Natural bioactive Polysaccharides have potential in the prevention and treatment of neurodegenerative diseases because of their advantageous characteristics,including multi-targeting,low toxicity,and synergistic effects.However,most of the recent related research has focused on cell and animal models.Future randomized clinical trials involving large sample sizes are needed to validate the therapeutic benefits of these neuroprotective Polysaccharides in patients having neurodegenerative diseases.

关键词： Alzheimer’s disease apoptosis experimental research neurodegeneration neuroinflammation neuroprotective oxidative stress Parkinson’s disease Polysaccharides protective mechanisms

Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

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Food Science and Human Wellness 2024年第3期13卷 1513-1530页

作者： Mingzhi Zhu Bohao Shang Fang Zhou Yong Yuan Feiyan Yin Jin Cao Jianan Huang Kunbo Wang Xin Zeng Maiquan Li Zhonghua Liu College of Horticulture Hunan Agricultural UniversityChangsha 410128China College of Life Sciences Huaibei Normal UniversityHuaibei 235000China Hunan Tea Group Co. Ltd.Changsha 410128China School of Food Science and Technology Hunan Agricultural UniversityChangsha 410128China

Golden-flower fungus,the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea,is considered a potential probiotic fungus based on its anti-obesity effect.However,the classification of golden-flower fungi is still controversial;the anti-obesity effect of golden-flower fungus Polysaccharides remains unknown.In this study,we identify a golden-flower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis,which resolves the controversy of classification.Moreover,we find A.cristatus Polysaccharides(ACPS)attenuate obesity in rats.ACPS modulate gut bacterial composition.in which Akkermansia,Akkermansia muciniphila,Bacteroides,Romboutsia,Blautia,and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum,hepatic,and fecal total bile acid content.Furthermore,ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity,according to a fecal transplantation experiment.Thus,ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.

关键词： Golden-flower fungus Aspergillus cristatus Polysaccharides Obesity Gut microbiota

Physicochemical properties and biological activities of Polysaccharides from the peel of Dioscorea opposita Thunb.extracted by four different methods

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Food Science and Human Wellness 2023年第1期12卷 130-139页

作者： Zuowei Zhao Li Wang Yuan Ruan Chunnan Wen Menghuan Ge Yanyan Qian Bingji Ma Department of Traditional Chinese Medicine Henan Agricultural UniversityZhengzhou 450001China

Polysaccharides are the important biologically active components found in the peel of Dioscorea opposita Thunb.(DTTP).The influences of 4 extraction methods,namely hot water extraction(W),acidic extraction(HA),hot-compressed water extraction(HCW)and enzyme-assisted extraction(EAE),on the yields,physicochemical properties,hypoglycemic and antioxidant activities of Polysaccharides from DTTP were studied and compared.Among these DTTP Polysaccharides,DTTP-HA was outstanding in several respects.DTTP-HA was the most water soluble;it had the highest total carbohydrate content(85.08%),the highest uronic acid(13.20%)and the highest thermal stability.DTTP-HA and DTTP-W possessed a triple-helix structure.These 4 kinds of Polysaccharides have the same types of monosaccharides,but in different molar percentages.Extraction method had a significant impact on the microstructures of the extracted Polysaccharides.DTT-HA exhibited irregular structure with many holes.Among the 4 extracted methods,the DTTP-HA and DTTP-W initially exhibited higher hypoglycemic and antioxidant activities.The better bioactivities of DTTP-HA may be related to the above factors.The findings indicated that acid extraction is an effective method to extract Polysaccharides with high biological activities from DTTP.

关键词： Dioscorea opposita Thunb peel Polysaccharides Different extraction methods Physicochemical characteristics Biological activities

Review on mechanisms and structure-activity relationship of hypoglycemic effects of Polysaccharides from natural resources

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Food Science and Human Wellness 2023年第6期12卷 1969-1980页

作者： Xiaolong Ji Jianhang Guo Tengzheng Cao Tingting Zhang Yanqi Liu Yizhe Yan College of Food and Bioengineering Zhengzhou University of Light IndustryZhengzhou 450001China Henan Key Laboratory of Cold Chain Food Quality and Safety Control Zhengzhou 450001China Collaborative Innovation Center of Food Production and Safety Henan ProvinceZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou University of Light IndustryZhengzhou 450001China

Diabetes mellitus(DM)is a common multifactorial disease,causing various complications,such as chronic metabolism.The current therapies for diabetes mellitus are commercial diabetic drugs that have different definite side effect.However,Polysaccharides mainly extracted from natural resources,have advantages of safety,accessibility,and anti-diabetic potential.We have summarized recent research of natural Polysaccharides with hypoglycemic activities,focusing on different pharmacological mechanisms in various cell and animal models.The relationships of structure-hypoglycemic effect are also discussed in detail.This review could provide a comprehensive perspective for better understanding on development and mechanism of natural Polysaccharides against diabetes mellitus,which have been required by clinical studies yet.

关键词： Polysaccharides Hypoglycemic effect Mechanisms Structure-activity relationship

Synchronous removal of CuO nanoparticles and Cu2+ by polyaluminum chloride-Enteromorpha Polysaccharides: Effect of Al species and pH

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Journal of Environmental Sciences 2020年第2期32卷 1-11页

作者： Yuanxia Luo Baoyu Gao Jie Wang Qinyan Yue Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong University266000 QingdaoChina

Copper oxide nanomaterials have been extensively applied and can have serious impacts when discharged into the aquatic environment, especially when complexed with humic acid(HA) to form composite contaminants.As an innovative recycled coagulant aid,Enteromorpha Polysaccharides(Ep) were associated with polyaluminum chloride(PACl)(denoted as PACl-Ep) to simultaneously remove CuO nanoparticles, Cu2+and HA in this study.The influence of different Al species coagulants(AlCl3, PAClb and PAClc) and water pH on coagulation performance, floc properties and reaction mechanisms was investigated in detail.Results showed that in the three PACl-Ep systems, PAClb-Ep gave the highest removal efficiencies for turbidity and Cu2+, and the best UV254 removal effect was reached by using PAClc-Ep.Higher contents of Alb and Alc contributed to great coagulation performance because of their stronger bridging and sweeping effects.For all the Al species coagulants, alkalescent conditions were more conducive to removing Cu and HA compared to acidic conditions.Additionally, smaller and more agminated flocs with great recovery ability were formed by PAClb-Ep and PAClc-Ep systems(bridging and enmeshment effects cooperated with the chelated reticular structure formed by the Ep and Al species).Similarly,due to the increased hydrolysis and hydroxide precipitates, flocs formed under the condition of alkalescence were smaller, denser and stronger compared with weakly acidic conditions.

关键词： Al species Enteromorpha Polysaccharides Polyaluminum chloride 27Al nuclear magnetic resonance Simultaneous removal

Anti-Inflammatory Effect of Dendrobium Huoshanense Polysaccharides on Carrageenan-Induced Air Pouch Synovitis in Mice

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World Journal of Traditional Chinese Medicine 2023年第4期9卷 399-403页

作者： Hai‑Jun Xu Yang Yang Ya‑Qi Dong Kai‑Min Niu Tian‑Yu Li Hui Deng Jing‑Wen Hao Wassie Teketay Teaching and Research Section of Animal Medicine College of Biological and Pharmaceutical EngineeringWest Anhui University Engineering Technology Research Center of Plant Cell Engineering Anhui Engineering Laboratory for Conservation and Sustainable Utilization of Traditional Chinese Medicine Resources Anhui ProvinceLuan Institute of Biological Resources Jiangxi Academy of SciencesJiangxi ProvinceNanchang Key Laboratory of Agro‑Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan ProvinceChangshaChina Department of Animal Science Assosa UniversityAssosaEthiopia

Objective:The purpose was to observe the anti-inflammatory effects of Dendrobium huoshanense Polysaccharides(DHPs)on carrageenan-induced sterile air pouch synovitis.Materials and Methods:A total of 30 Institute of Cancer Research(ICR)mice were randomly and equally assigned to the control,carrageenan-induced air pouch synovitis model(model),and carrageenan-induced air pouch synovitis model+DHP(200 mg/kg of body weight)(model+DHP)groups.Mice in the model+DHP group were intragastrically administered 200 mg/kg BW of DHP solution daily for 10 days.Mice in the control and model groups were intragastrically administered the same amount of distilled water.Two hours after intragastric administration on day 10,1 mL of a 1%carrageenan solution in a sterile 0.9%saline solution was injected into the air pouch of mice in the model and model+DHP groups.Six hours later,the mice were sacrificed and 4 mL of ice-cold sterile 0.9%saline solution was injected into the air pouch to fully wash its inner wall.The lavage fluid was collected to observe the color and turbidity of the lavage fluid,as well as the appearance of the backside of the air pouch.The exudate volume,total number of leukocytes,protein content,levels of malondialdehyde(MDA),interleukin-1β(IL-1β),and tumor necrosis factor-alpha(TNF-α),and total superoxide dismutase(T-SOD)activity of the lavage fluid were analyzed.Results:The results showed that pretreatment with DHPs reduced the carrageenan-induced exudate volume(P<0.01),total leukocytes(P<0.05),and protein content(P<0.01)in the air pouch lavage fluid.Furthermore,mice in the model+DHP group had significantly higher(P<0.01)T-SOD activity and lower MDA content(P<0.05),IL-1β(P<0.05),and TNF-α(P<0.01)levels in the air pouch lavage fluid compared with the model group.Conclusion:It is concluded that DHPs partially alleviated carrageenan-induced sterile inflammation,and its mechanism may be related to reducing exudation and scavenging oxygen-free radicals,inhibiting lipid peroxidation,and reducing the level of the proinflamma

关键词： Anti-inflammation carrageenan Dendrobium huoshanense Polysaccharides sterile inflammation

Polysaccharides from Agrocybe cylindracea residue alleviate type 2-diabetes-induced liver and colon injuries by p38 MAPK signaling pathway

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Food Bioscience 2022年第3期47卷 858-872页

作者： Wenxue Sun Yaohan Zhang Le Jia College of Life Science Shandong Agricultural UniversityTaian271018PR China

In this experiment,we investigated the possible mechanism of Polysaccharides from Agrocybe cylindracea residue (PACR) on ameliorating the type-2-diabetes-induced liver and colon injuries.Animal experiments have proved that PACR could reduce the oxidative damage and inflammatory response.Meanwhile,the PACR could restore lipid levels,decrease the level of liver and colon lesions in injured mice,and finally play a role in protecting liver and colon.The results showed that PACR could be used as a supplement to decrease blood glucose and relieve T2DM and reduce oxidative stress and inflammatory response by inhibiting the activation of p38 MAPK signaling pathway.

关键词： Type 2 diabetes Polysaccharides p38 MAPK signal pathways

A review of isolation methods, structure features and bioactivities of Polysaccharides from Dendrobium species

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Chinese Journal of Natural Medicines 2020年第1期18卷 1-27页

作者： YUE Han ZENG Hui DING Kan Glycochemistry and Glycobiology Lab Key Laboratoty of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China

Dendrobium,orchid,is a traditional Chinese herb medicine applied extensively as tonic and precious food for thousands of years recorded in ancient Chinese medical book"Shen Nong’s Materia Medica".It’s well known that bioactivities are usually related to the ingredients’basis.Based on the previous research,Dendrobium species contain amino acid,sesquiterpenoids,alkaloids and Polysaccharides.As the bioactive substances,carbohydrate shows extensive activities in antitumor,antiglycation,immune-enhancing,antivirus,antioxidant,antitumor and etc.Therefore,as the main biologically active substance,the exact structures and latent activities of Polysaccharides from Dendrobium species are widely focused on.In this review,we focus on the advancements of extraction methods and diversity of structures and bioactivities of Polysaccharides obtained from Dendrobium species.

关键词： Dendrobium Polysaccharides Bioactivities Structures

Antioxidative and immunological effects of Cyclocarya paliurus Polysaccharides on the spleen injury of diabetic rats

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Journal of Traditional Chinese Medicine 2021年第5期41卷 739-746页

作者： XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng Medical College Pingdingshan UniversityPingdingshan 467000China College of Chemistry and Chemical Engineering Pingdingshan UniversityPingdingshan 467000China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)Polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus Polysaccharides treatment,middle-dose group of C.paliurus Polysaccharides treatment and high-dose group of C.paliurus Polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(PPolysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(PPolysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus Polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity.

关键词： spleen diabetes mellitus antioxidants Polysaccharides Cyclocarya paliurus