Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

作     者：ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING Yan-qing ZHENG Jun DUAN Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun ZHAO Wen-xiao;WANG Tong;ZHANG Ya-nan;CHEN Qian;WANG Yuan;XING Yan-qing;ZHENG Jun;DUAN Chen-chen;CHEN Li-jun;ZHAO Hai-jun;WANG Shi-jun

作者机构：School of NursingShandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine FormulaShandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinan(250355)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2024年第30卷第2期

页      面：171-180页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the National Natural Science Foundation of China(No.81903947) the Key Research and Development Project of Shandong Province,China(No.2019GSF108209) Key Basic Research of the Natural Science Foundation of Shandong Province,China(No.ZR2019ZD23) Shandong University Youth Innovative Talent Introduction Project(LJRZ 2019,No.9-201)。 

主　　题：Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions 

摘      要：The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.