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Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and antiinflammatory capacity for facilitating pelvic floor repair

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Regenerative Biomaterials 2022年第1期9卷 871-887页

作者： Chenghao Wu Zixuan Zhou Xi You Yi Guo Ping Chen Huaifang Li Xiaowen Tong Department of Obstetrics and Gynecology Tongji HospitalTongji University School of MedicineShanghai 200065People’s Republic of China Department of Burn Surgery The First Affiliated Hospital of Naval Medical UniversityBurn Institute of PLAShanghai 200433People’s Republic of China School of Life Sciences and Technology Tongji UniversityShanghai 200092People’s Republic of China

The application of polypropylene mesh(PPM)in pelvic organ prolapse(POP)treatment was severely limited by the complications associated with PPM,such as mesh exposure,chronic inflammatory reactions and postoperative *** study applied a method of fabricating a hydrogel-mesh complex(PPM+TA@GelMA)to cross-link tannic acid(TA)directly with Methacrylate Gelatin(GelMA)hydrogel and thus to form a coating for *** one-step coating modification improved the hydrophilicity and cyto-compatibility of *** hemostatic effect of PPMtTA@GelMA was confirmed through tail amputation *** the defect tissue repair experiments in vivo,it was proved that PPMtTA@GelMA had effects of anti-inflammation and promoting tissue repair and regulated the M2 subtype macrophages polarization for tissue *** TAloaded hydrogel coating endued PPM with multiple *** is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

关键词： tannic acid hydrogel polypropylene mesh pelvic floor repair

An innovative technique of chest wall stabilization and reconstruction in traumatic flail chest:The figure-of-eight suture with polypropylene mesh and musculofascial flap

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Chinese Journal of Traumatology 2022年第2期25卷 122-124页

作者： Klein Dantis Swagata Brahmachari Aghosh Raju Suprabha Shankari Department of Cardiothoracic and Vascular Surgery All India Institute of Medical SciencesRaipurIndia Department of General Surgery All India Institute of Medical SciencesBhopalIndia

Surgical stabilization of the flail chest is challenging and has no established *** wall integrity and stability are the main factors that ensure the protection of intrathoracic organs and an adequate respiratory ***,we report a novel chest wall reconstruction technique in a 45-year-old man with a traumatic left flail chest and open pneumothorax diagnosed both clinically and *** approximation and chest wall reconstruction was done using intercostal figure-of-eight suture and polypropylene mesh with vascularized musculofascial *** patient improved gradually and was discharged after three weeks of total hospital *** returned to regular working after a month with no evidence of respiratory distress or paradoxical chest ***-up visit at one year revealed no lung hernia or paradoxical chest *** is a novel,feasible and cost-effective modification of chest wall reconstruction that can be adopted for thoracic wall repair in case of open flail chest,which needs emergency surgical interventions even in resource constraint settings.

关键词： Flail chest Open pneumothorax polypropylene mesh Figure-of-eight suture Chest wall reconstruction

Establishment and evaluation of an improved rat model of open abdomen

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Animal Models and Experimental Medicine 2024年第4期7卷 562-569页

作者： Ye Liu Sicheng Li Jinjian Huang Ze Li Kang Chen Guiwen Qu Xiuwen Wu Jianan Ren School of Medicine Southeast UniversityNanjingChina Research Institute of General Surgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina

Introduction:This study aimed to establish an animal model of open abdomen(OA)through temporary abdominal closure via different ***:Adult male Sprague-Dawley rats were randomly divided into three groups:group A(OA with polypropylene mesh alone);group B(OA with polypro-pylene mesh combined with a patch);and group C(OA with polypropylene mesh and a sutured patch).Vital signs,pathophysiological changes,and survival rates were closely monitored in the rats for 7 days after *** X-rays and histopathological examinations were performed to assess abdominal organ changes and wound ***:The results showed no significant difference in mortality rates among the three groups(p>0.05).However,rats in group B exhibited superior overall condi-tion,cleaner wounds,and a higher rate of wound healing compared to the other groups(ppolypropylene mesh combined with patches is the most suitable method for establishing an animal model of *** model successfully replicated the patho-logical and physiological changes in postoperative patients with OA,specifically the progress of abdominal skin wound *** provides a practical and reliable animal model for OA research.

关键词： animal models open abdomen patch polypropylene mesh

Intestinal erosion caused by meshoma displacement:A case report

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 114-120页

作者： Jin-Feng Wu Jian Chen Fang Hong Department of General Surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Gynaecology and Obstetrics Zhejiang University School of Medicine Sir Run Run Shaw HospitalHangzhou 310016Zhejiang ProvinceChina

BACKGROUND A meshoma formation and erosion to the small intestine is ***,we report one case of a meshoma that was not treated early;causing it to displace and erode the small intestine,with infection,complete control of symptoms was achieved after removal of the infected patch mass,no recurrence of hernia after 2 years of *** SUMMARY A 62-year-old male patient presented with recurrent abdominal pain repeatedly for 1 wk,which has worsened 2 d before admition,accompanied by *** years before presentation he underwent right inguinal hernia Plug and patch repair *** years ago,a computed tomography scan revealed a right lower abdominal mass with soft tissue density,measuring approximately 30 mm×17 mm,which was diagnosed as meshoma that was not *** patient had poorly controlled diabetes in the past *** The formation of meshoma is rare,and that if not treated in time it might erode and require resection of the involved organ.

关键词： Tension-Free mesh repair polypropylene mesh meshoma mesh infection Bowel resection Case report