Establishment and evaluation of an improved rat model of open abdomen

作     者：Ye Liu Sicheng Li Jinjian Huang Ze Li Kang Chen Guiwen Qu Xiuwen Wu Jianan Ren Ye Liu;Sicheng Li;Jinjian Huang;Ze Li;Kang Chen;Guiwen Qu;Xiuwen Wu;Jianan Ren

作者机构：School of MedicineSoutheast UniversityNanjingChina Research Institute of General SurgeryAffiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2024年第7卷第4期

页      面：562-569页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Postgraduate Research&Practice Innovation Program of Jiangsu Province,Grant/Award Number:SJCX23_0092 National Natural Science Foundation of China,Grant/Award Number:82270595 Jiangsu Provincial Medical Innovation Center,Grant/Award Number:CXZX202217 

主　　题：animal models open abdomen patch polypropylene mesh 

摘      要：Introduction:This study aimed to establish an animal model of open abdomen(OA)through temporary abdominal closure via different ***:Adult male Sprague-Dawley rats were randomly divided into three groups:group A(OA with polypropylene mesh alone);group B(OA with polypro-pylene mesh combined with a patch);and group C(OA with polypropylene mesh and a sutured patch).Vital signs,pathophysiological changes,and survival rates were closely monitored in the rats for 7 days after *** X-rays and histopathological examinations were performed to assess abdominal organ changes and wound ***:The results showed no significant difference in mortality rates among the three groups(p0.05).However,rats in group B exhibited superior overall condi-tion,cleaner wounds,and a higher rate of wound healing compared to the other groups(p0.05).Abdominal X-rays indicated that varying degrees of distal intestinal obstruction in all *** examinations revealed fibrous hyperpla-sia,inflammatory cell infiltration,neovascularization,and collagen deposition in all *** B demonstrated enhanced granulation tissue generation,neovasculari-zation,and collagen deposition compared to the other groups(p0.05).Conclusions:Polypropylene mesh combined with patches is the most suitable method for establishing an animal model of *** model successfully replicated the patho-logical and physiological changes in postoperative patients with OA,specifically the progress of abdominal skin wound *** provides a practical and reliable animal model for OA research.