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A practical guide to pharmaceutical polymorph screening & selection

Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 163-175页

作者： Eun Hee Lee College of Pharmacy Korea University2511 Sejong-roSejong 339-700Republic of Korea

Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well *** is of great importance to prepare and select the right form from the beginning during drug discovery and *** review introduces the basic concepts of“What is polymorphism?”,addresses a fundamental question of“Why do polymorphs form?”,and provides practical guidelines of“How to prepare polymorphs?”“How to evaluate the relative thermodynamic stability between polymorphs?”,and“How to analyze polymorphs?”.Moreover,case studies of pharmaceutically important polymorphs are provided.

关键词： polymorphs polymorph screening polymorph selection polymorph preparation

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screening, Characterization and Evaluation of Mangiferin polymorphs

引用

Natural Products and Bioprospecting 2020年第4期10卷 187-200页

作者： Shiying Yang Qi Zhou Baoxi Zhang Li Zhang Dezhi Yang Haiguang Yang Guanhua Du Yang Lu Beijing Key Laboratory of polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Targets and screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Mangiferin is a compound with many pharmacological activities and exists in many natural *** and hydrate of mangiferin have been reported separately in two literatures,but the polymorphism of this compound has not been realized until this *** this study,polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never *** solid state characterization methods,such as powder X-ray diffraction,differential scanning calorimetry and thermogravimetry,are used to identify and characterize all of mangiferin *** comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and ***,the studies on stability,transformation and solubility have been undertaken,the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals.

关键词： Mangiferin polymorph screening Characterize Stability Solubility

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