Screening, Characterization and Evaluation of Mangiferin Polymorphs

作     者：Shiying Yang Qi Zhou Baoxi Zhang Li Zhang Dezhi Yang Haiguang Yang Guanhua Du Yang Lu 

作者机构：Beijing Key Laboratory of Polymorphic DrugsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Targets and Screening ResearchInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2020年第10卷第4期

页      面：187-200页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：support from Key National Research and Development Programmes(Grant No.2016YFC1000905) the Drug Innovation Major Project(Grant No.2018ZX09711001-001-013) the National Natural Science Foundation of China(Grant No.81703473) the Drug Innovation Major Project(Grant No.2018ZX09711001-010,2017ZX09101001003) CAMS Innovation Found for Medical Sciences(Grant No.2016-I2M-1-007) 

主　　题：Mangiferin Polymorph screening Characterize Stability Solubility 

摘      要：Mangiferin is a compound with many pharmacological activities and exists in many natural *** and hydrate of mangiferin have been reported separately in two literatures,but the polymorphism of this compound has not been realized until this *** this study,polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never *** solid state characterization methods,such as powder X-ray diffraction,differential scanning calorimetry and thermogravimetry,are used to identify and characterize all of mangiferin *** comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and ***,the studies on stability,transformation and solubility have been undertaken,the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals.