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Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

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Bioactive Materials 2022年第3期7卷 77-91页

作者： Yi Han Lu Jiang Huihui Shi Chenfang Xu Minting Liu Qingjian Li Lan Zheng Hong Chi Mingyue Wang Zuguo Liu Mingliang You Xian Jun Loh Yun-Long Wu Zibiao Li Cheng Li Fujian Provincial Key Laboratory of Ophthalmology and Visual Science&Ocular Surface and Corneal Diseases Eye Institute&Affiliated Xiamen Eye CenterSchool of MedicineXiamen UniversityXiamen361102China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore School of Chemical Sciences University of Chinese Academy of ScienceBeijing100049China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of ScienceNingbo315201China Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen361102China Hangzhou Cancer Institute Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou310002China Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Pharmaceutical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan250353China Department of Materials Science and Engineering National University of SingaporeSingapore117575Singapore

Dry eye is a common ocular disease that results in discomfort and impaired vision,impacting an individual’s quality of life.A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface,which limits their therapeutic ***,it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular ***,we develop a copolymer from mono-functional POSS,PEG,and PPG(MPOSS-PEG-PPG,MPEP)that exhibits temperature-sensitive sol-gel transition *** thermo-responsive hydrogel improves the water solubility of FK506 and simultaneously provides a mucoadhesive,long-acting ocular delivery *** addition,the FK506-loaded POSS hydrogel possesses good biocompatibility and significantly improves adhesion to the ocular *** comparison with other FK506 formulations and the PEG-PPG-FK506(F127-FK506)hydrogel,this novel MPOSS-PEG-PPG-FK506(MPEP-FK506)hydrogel is a more effective treatment of dry eye in the murine dry eye ***,delivery of FK506 in this POSS hydrogel has the potential to prolong drug retention time on the ocular surface,which will improve its therapeutic efficacy in the management of dry eye.

关键词： Ocular adhesive polyhedral oligomeric silsesquioxane FK506 Dry eye

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Synthesis and Luminescent Property of Polycarbazole/polyhedral oligomeric silsesquioxane Nanocomposites

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Chemical Research in Chinese Universities 2008年第5期24卷 570-574页

作者： ZHU Yu-fang ZHAO Jun-feng WANG Xi LI Qi-fang College of Material Science and Engineering State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Henan Institute of Engineering Zhengzhou 451191 P. R. China

Polyvinylcarbazole（PVK） composites containing organic-inorganic hybrid polyhedral oligomeric silse-squioxane（POSS） PVK-POSS were prepared by free radical polymerization. POSS monomers reacted with vinylcarbazole and were completely dispersed at molecular level in PVK matrix and PVK-POSS nanocomposites display higher glass transition temperature（Tg） in comparison with neat PVK. Optical properties of PVK/POSS nanocomposites were investigated by UV-spectrum and PL-spectrum and the results show that the PVK-POSS nanoparticles have a good interface effect and improve color purity effectively. The maximum absorption wavelength bathochromically shifts gradually with the increasing of the content of POSS. The luminescent intensity becomes higher and higher with the increase of POSS content, and reaches its maximum luminescent intensity when the POSS content is 3% （mass fraction）, while some POSS-rich nanoparticles are present in matrix when contents of POSS are beyond 5%.

关键词： polyhedral oligomeric silsesquioxane Luminescence Polyvinylcarbazole Nanocomposite

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Study of Flame Retardation of Polycarbonate Modified by polyhedral oligomeric silsesquioxane and Caged Bicyclic Phosphate

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Journal of Beijing Institute of Technology 2010年第4期19卷 480-486页

作者：蒋云芸杨荣杰 School of Materials Science and Engineering Beijing Institute of Technology

The flame-retarded polycarbonate（PC） has been made with octaphenyl polyhedral silsesquioxane（OPS） and/or caged bicyclic phosphate（Trimer）.Thermal gravimetric analysis（TGA）,Fourier-transform infrared（FTIR）,TGA-FTIR,limiting oxygen index（LOI）,and mechanical tests have been employed to characterize the modified *** additives of OPS and Trimer in PC have been proved to be effective flame-retardants because of the synergistic interaction between the elements of P and *** role of OPS and Trimer in PC degradation are different：OPS participates in the charring of PC,while Trimer makes PC degrade in *** addition,OPS and Trimer induced obvious differences in the mechanical properties of PC.

关键词： polycarbonate flame retardancy polyhedral oligomeric silsesquioxane caged bicyclic phosphate

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Polymer solar cells with an inverted device configuration using polyhedral oligomeric silsesquioxane-[60]fullerene dyad as a novel electron acceptor

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Science China Chemistry 2012年第5期55卷 749-754页

作者： ZHANG Wen-Bin TU YingFeng SUN Hao-Jan YUE Kan GONG Xiong CHENG Stephen Z. D. College of Polymer Science and Polymer Engineering The University of Akron Akron OH 44325 USA College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

A polyhedral oligomeric silsesquioxane-[60]fullerene (POSS-C60) dyad was designed and used as a novel electron acceptor for bulk heterojunction (BHJ) polymer solar cells (PSCs) with an inverted device configuration. The studies of time-resolved photoinduced absorption of the pristine thin film of poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d]silole)-2,6-diyl-alt-(4,7-bis (2-thienyl)-2,1,3-benzothiadiazole)-5,5'-diyl] (SiPCPDTBT) and the composite thin film of SiPCPDTBT:POSS-C60 indicated efficient electron transfer from SiPCPDTBT to POSS-C60 with inhibited back-transfer. BHJ PSCs made by SiPCPDTBT mixed with POSS-C60 yielded the power conversion efficiencies (PCEs) of 1.50%. Under the same operational conditions, PCEs observed from BHJ PSCs made by SiPCPDTBT mixed with [6,6]-phenyl-C61-butyric acid methyl ester were 0.92%. These results demonstrated that POSS-C60 is a potentially good electron acceptor for inverted BHJ PSCs.

关键词： electron acceptor polyhedral oligomeric silsesquioxane fullerene polymer solar cells inverted device structure

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Effect of polyhedral oligomeric silsesquioxane and Sorbitol on Properties of Isotactic Polypropylene

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Chemical Research in Chinese Universities 2015年第2期31卷 303-307页

作者： CHEN Guanyun FENG Baixuan ZHU Kongying ZHAO Yunhui YUAN Xiaoyan School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Analysis and Measurement Center Tianjin University Tianjin 300072 P. R. China

Isotactic polypropylene（iPP） was modified by the introduction of polyhedral oligomeric silsesquioxanes（POSS） and 1,3：2,4-bis（3,4-dimethylbenzylidene）sorbitol（DMDBS）. Chemical combination of （3-mercapto）- propyl-heptaisobutyl POSS with DMDBS（POSS-DMDBS）, and physical mixing of DMDBS with octaisobutyl POSS （iso-POSS/DMDBS） or trisilanolisobutyl POSS（tri-POSS/DMDBS） were applied respectively to modifying iPP, and the effects of POSS and DMDBS on crystallization, rheological and mechanical properties of iPP were systematically investigated. The results indicate that iso-POSS/DMDBS and tri-POSS/DMDBS were more effective than POSS-DMDBS on the improvement of the crystallization behavior of iPP due to the higher crystallization temperature, while the crystal!inity of iPP containing POSS-DMDBS was enhanced, approximately approached to that of iPP containing tri-POSS/DMDBS. The tensile strength of iPP with POSS-DMDBS was significantly increased from 34 MPa to 40 MPa, as high as that of iPP with iso-POSS/DMDBS. The different effects caused by the specific interaction between POSS and DMDBS could possibly be applied in the modification of iPP.

关键词： Isotactic polypropylene polyhedral oligomeric silsesquioxane Sorbitol

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Ionic Liquid 1-Vinyl-3-dodecylimidazole Bromide Embedded Hybrid Monolithic Column and Its Versatile Post-modification with Amino Acids

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Journal of Analysis and Testing 2021年第4期5卷 387-395页

作者： Yufeng Zhou Liguang Duan Yixin Huang Yaqi Liu Lijuan Wang Xiaoqiang Qiao College of Pharmaceutical Sciences Key Laboratory of Public Health Safety of Hebei ProvinceHebei UniversityBaoding 071002China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis Ministry of EducationInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China The First Hospital of Hebei Medical University Shijiazhuang 050031China

The amino acids post-modified ionic liquids-based hybrid monolithic columns were successfully *** the first step,using 1-vinyl-3-dodecylimidazole bromide(VDI·Br)and polyhedral oligomeric silsesquioxane methacryl substituted(POSS-MA)as monomer and crosslinking agent,the monolithic POSS-VDI matrix material was polymerized in 100μm *** prepared POSS-VDI column is of ion-exchange/reverse-phase mixed-mode retention *** column e fficiency reached 137,000 N/m for *** POSS-VDI column has also been successfully applied to recognize and analyze the eff ective components of Traditional Chinese Medicines Fangji and the Root of Kudzu ***,based on its good chromatographic performances,in the second step,amino acids L-Proline(L-Pro),Glycine(Gly)or DLPhenylalanine(DL-Phe)were further exploited as the anion exchangers to post-modify the POSS-VDI *** new POSS-VDI-Pro,POSS-VDI-Gly and POSS-VDI-Phe columns exhibited diff erent separation selectivity for the complex egg white protein *** present work provides a good route to fabricate versatile amino acids and ionic liquids modified monolithic columns with good separation selectivity.

关键词： Monolithic column Chromatographic separation polyhedral oligomeric silsesquioxane Amino acid and ionic liquids Mixed mode

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Synthesis of Liquid-like Trisilanol Isobutyl-POSS NOHM and Its Application in Capturing CO2

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Chemical Research in Chinese Universities 2015年第3期31卷 484-488页

作者： BAI Haipeng ZHENG Yaping LI Peipei ZHANG Aibo School of Natural and Applied Science Northwestern Polytechnical University Xi&#39 an 710072 P.R.China

The trisilanol isobutyl polyhedral oligomeric silsesquioxane（POSS） was fabricated into liquid-like nano- particle organic hybrid materials（NOHMs） with ）,-（2,3-epoxypropoxy）propytrimethoxysilane as corona and polyethe- ramine M2070 as canopy, and the product was called liquid-like POSS NOHM. The liquid-like POSS NOHM has a low viscosity at room temperature without any solvent and the mass fraction of trisilanol isobutyl POSS was 23.38%. The liquid-like POSS NOHM shows great CO2 capturing property with a capacity of 2.108 mmol/g（PCO2=6 MPa）. The physical adsorption increased obviously with the pressure going up and it may make a difference between liquid-like POSS NOHMs and traditional monoethamolamine（MEA） based CO2 absorbent. The recycle property was also studied. The NOHM behaved as fresh product even after 10 cycles.

关键词： Liquid-like nanoparticle organic hybrid material polyhedral oligomeric silsesquioxane CO2 capture

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笼型硅氧烷低聚物（POSS）在制备高性能芯片粘接膜中的多重作用研究

笼型硅氧烷低聚物（POSS）在制备高性能芯片粘接膜中的多重作用研...

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2012年全国高分子材料科学与工程研讨会

作者：盛文佳水晓雪由吉春赵丽萍曹肖君董文勇李勇进杭州师范大学

＜正＞芯片粘结膜的高性能化（高粘接强度、高耐热性、低交联收缩率、低热膨胀率等）是半导体器件小型化轻量化、柔性化的前提。本论文以丙烯酸酯橡胶（ACM）/环氧树脂（Epoxy）共混体系为基体,系统研究环氧基笼型硅氧烷低聚物（POSS）... 详细信息

＜正＞芯片粘结膜的高性能化（高粘接强度、高耐热性、低交联收缩率、低热膨胀率等）是半导体器件小型化轻量化、柔性化的前提。本论文以丙烯酸酯橡胶（ACM）/环氧树脂（Epoxy）共混体系为基体,系统研究环氧基笼型硅氧烷低聚物（POSS）对丙烯酸酯橡胶/环氧树脂共

关键词： polyhedral oligomeric silsesquioxane diebond adhesive films Reaction induced phase separation nanocomposites

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SEBS-g-POSS的合成、表征与性能

SEBS-g-POSS的合成、表征与性能

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2014年全国高分子材料科学与工程研讨会

作者：徐日炜钟廷家李滔谷晓昱余鼎声吴一弦碳纤维及功能高分子教育部重点实验室北京化工大学

＜正＞SEBS微观两相（软相和硬相）分离的结构分别为材料提供了弹性和刚性,使其拥有着橡胶弹性和塑料热塑加工性,这些优良的特性使得其得到了广泛的应用,但其耐热性相对较差限制了使用范围。随着聚合物基纳米有机-无机杂化材料的发展,... 详细信息

＜正＞SEBS微观两相（软相和硬相）分离的结构分别为材料提供了弹性和刚性,使其拥有着橡胶弹性和塑料热塑加工性,这些优良的特性使得其得到了广泛的应用,但其耐热性相对较差限制了使用范围。随着聚合物基纳米有机-无机杂化材料的发展,如果能利用纳米材料针对性地改善热塑性弹性体的硬段,可以实现热塑性弹性体的高功能化和高性能化。多面体低聚倍半硅氧烷（POSS）作为一种无机-有机纳米材料,与一般的纳米填充材料相比,具有更好的结构可设计性及聚合物的相容性。我们课题组用点击化学方法（炔基-叠氮Huisgen环加成反应）

关键词： polyhedral oligomeric silsesquioxane vertex groups thermoplastic elastomer hybrid materials

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