Ionic Liquid 1-Vinyl-3-dodecylimidazole Bromide Embedded Hybrid Monolithic Column and Its Versatile Post-modification with Amino Acids

作     者：Yufeng Zhou Liguang Duan Yixin Huang Yaqi Liu Lijuan Wang Xiaoqiang Qiao 

作者机构：College of Pharmaceutical SciencesKey Laboratory of Public Health Safety of Hebei ProvinceHebei UniversityBaoding 071002China Key Laboratory of Medicinal Chemistry and Molecular DiagnosisMinistry of EducationInstitute of Life Science and Green DevelopmentHebei UniversityBaoding 071002China The First Hospital of Hebei Medical UniversityShijiazhuang 050031China 

出 版 物：《Journal of Analysis and Testing》 (分析检测（英文）)

年 卷 期：2021年第5卷第4期

页      面：387-395页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：financial support from Hundred Outstanding Innovative Talents in Universities of Hebei Province(SLRC2019016) Natural Science Foundation of Hebei Province(B2019201327) Young Talent of Hebei Province National Natural Science Foundation of China(21675039) Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine(2015116) 

主　　题：Monolithic column Chromatographic separation Polyhedral oligomeric silsesquioxane Amino acid and ionic liquids Mixed mode 

摘      要：The amino acids post-modified ionic liquids-based hybrid monolithic columns were successfully *** the first step,using 1-vinyl-3-dodecylimidazole bromide(VDI·Br)and polyhedral oligomeric silsesquioxane methacryl substituted(POSS-MA)as monomer and crosslinking agent,the monolithic POSS-VDI matrix material was polymerized in 100μm *** prepared POSS-VDI column is of ion-exchange/reverse-phase mixed-mode retention *** column e fficiency reached 137,000 N/m for *** POSS-VDI column has also been successfully applied to recognize and analyze the eff ective components of Traditional Chinese Medicines Fangji and the Root of Kudzu ***,based on its good chromatographic performances,in the second step,amino acids L-Proline(L-Pro),Glycine(Gly)or DLPhenylalanine(DL-Phe)were further exploited as the anion exchangers to post-modify the POSS-VDI *** new POSS-VDI-Pro,POSS-VDI-Gly and POSS-VDI-Phe columns exhibited diff erent separation selectivity for the complex egg white protein *** present work provides a good route to fabricate versatile amino acids and ionic liquids modified monolithic columns with good separation selectivity.