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SERS sensing for cancer biomarker:Approaches and directions

Bioactive Materials 2024年第4期34卷 248-268页

作者： Lorena Vázquez-Iglesias Giovanna Maria Stanfoca Casagrande Daniel García-Lojo Letícia Ferro Leal Tien Anh Ngo Jorge Pérez-Juste Rui Manuel Reis Krishna Kant Isabel Pastoriza-Santos CINBIO Universidade de VigoCampus Universitario As Lagoas MarcosendeVigo 36310Spain Galicia Sur Health Research Institute(IIS Galicia Sur) 36310VigoSpain Molecular Oncology Research Center Barretos Cancer HospitalBarretosBrazil Barretos School of Medicine Dr.Paulo Prata-FACISB Barretos14785-002Brazil Vinmec Tissue Bank Vinmec Health Care SystemHanoiViet Nam Life and Health Sciences Research Institute(ICVS) School of MedicineCampus de GualtarUniversity of Minho4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory 4710-057BragaPortugal

These days,cancer is thought to be more than just one illness,with several complex subtypes that require different screening *** subtypes can be distinguished by the distinct markings left by metabolites,proteins,miRNA,and *** illness management may be possible if cancer is categorized according to its *** order to stop cancer from spreading and posing a significant risk to patient survival,early detection and prompt treatment are *** cancer screening techniques are tedious,time-consuming,and require expert personnel for *** has led scientists to reevaluate screening methodologies and make use of emerging technologies to achieve better *** time and money saving techniques,these methodologies integrate the procedures from sample preparation to detection in small devices with high accuracy and *** its proven potential for biomedical use,surface-enhanced Raman scattering(SERS)has been widely used in biosensing applications,particularly in biomarker *** was given especially to the potential of SERS as a portable clinical diagnostic *** approaches to SERS-based sensing technologies for both invasive and non-invasive samples are reviewed in this article,along with sample preparation techniques and *** from these significant constraints in the detection approach and techniques,the review also takes into account the complexity of biological fluids,the availability of biomarkers,and their sensitivity and selectivity,which are generally *** ways to maintain sensing capabilities in clinical samples are being developed recently to get over this *** is known to be a reliable diagnostic method for treatment ***,there is still room for advancement in terms of portability,creation of diagnostic apps,and interdisciplinary AI-based ***,we will outline the current state of technological maturity f

关键词： Surface-enhanced Raman scattering(SERS) Cancer biomarkers Invasive and non-invasive biomarkers point of care detection Microfluidic devices

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