SERS sensing for cancer biomarker:Approaches and directions

作     者：Lorena Vázquez-Iglesias Giovanna Maria Stanfoca Casagrande Daniel García-Lojo Letícia Ferro Leal Tien Anh Ngo Jorge Pérez-Juste Rui Manuel Reis Krishna Kant Isabel Pastoriza-Santos 

作者机构：CINBIOUniversidade de VigoCampus Universitario As Lagoas MarcosendeVigo 36310Spain Galicia Sur Health Research Institute(IIS Galicia Sur)36310VigoSpain Molecular Oncology Research CenterBarretos Cancer HospitalBarretosBrazil Barretos School of Medicine Dr.Paulo Prata-FACISBBarretos14785-002Brazil Vinmec Tissue BankVinmec Health Care SystemHanoiViet Nam Life and Health Sciences Research Institute(ICVS)School of MedicineCampus de GualtarUniversity of Minho4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory4710-057BragaPortugal 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2024年第34卷第4期

页      面：248-268页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no.894227 The FET Open grant agreement no.965018(BIOCELLPHE) the MCIN/AEI/10.13039/501100011033 grant PID2019-108954RB-I00 GMSC is supported by Sao Paulo Research Foundation(FAPESP) LFL was supported by the Public Ministry of Labor Campinas(Research,Prevention,and Education of Occupational Cancer) funded by PRONON-PRONON/MS(Abordagens móveis e de tecnologia para prevenção prim´aria e secundária de câncer-NUP:25000.015000/2019-53) 

主　　题：Surface-enhanced Raman scattering(SERS) Cancer biomarkers Invasive and non-invasive biomarkers Point of care detection Microfluidic devices 

摘      要：These days,cancer is thought to be more than just one illness,with several complex subtypes that require different screening *** subtypes can be distinguished by the distinct markings left by metabolites,proteins,miRNA,and *** illness management may be possible if cancer is categorized according to its *** order to stop cancer from spreading and posing a significant risk to patient survival,early detection and prompt treatment are *** cancer screening techniques are tedious,time-consuming,and require expert personnel for *** has led scientists to reevaluate screening methodologies and make use of emerging technologies to achieve better *** time and money saving techniques,these methodologies integrate the procedures from sample preparation to detection in small devices with high accuracy and *** its proven potential for biomedical use,surface-enhanced Raman scattering(SERS)has been widely used in biosensing applications,particularly in biomarker *** was given especially to the potential of SERS as a portable clinical diagnostic *** approaches to SERS-based sensing technologies for both invasive and non-invasive samples are reviewed in this article,along with sample preparation techniques and *** from these significant constraints in the detection approach and techniques,the review also takes into account the complexity of biological fluids,the availability of biomarkers,and their sensitivity and selectivity,which are generally *** ways to maintain sensing capabilities in clinical samples are being developed recently to get over this *** is known to be a reliable diagnostic method for treatment ***,there is still room for advancement in terms of portability,creation of diagnostic apps,and interdisciplinary AI-based ***,we will outline the current state of technological maturity f