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Roles of platelet count and leukocyte count in predicting mortality in patients with severe burns

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Roles of platelet count and leukocyte count in predicting mo...

Combination of type Ⅳ collagen 7S, albumin concentrations, and platelet count predicts prognosis of non-alcoholic fatty liver disease

第七届全国呼吸系统重大疾病转化医学学术论坛

作者： Yu-bao Qiu Chen Wu Xue-qian Sun Dan Chen Jun-liang Chen Ya-xian Wu Qing-feng Pang Department of physiopathology Wuxi School of MedicineJiangnan University

Aim:Severe burn is one of the most severe forms of trauma and usually associated with high *** recent studies have shown that some factors or biomarkers have a predictive effect on post-burn mortality,there is still lack of effective methods for predicting severe burn *** aim of this study was to assess the predictive value of indicators related to complete blood count（CBC） to predict mortality in severe burn ***:This is a retrospective cohort study.A total of 33 patients were included in the *** blood samples were obtained for measuring CBC related *** curve analysis was performed to evaluate the effects of PLT,WBC,NeuC,NeuR,LymR and Hb on mortality in patients with severe ***:All patients with severe burn（92.21±11.93% TBSA） and inhalation injuries were caused by an ***-day mortality was 15.15%,and total in-hospital mortality was 24.24%.For both 40-day and total in-hospital analyses,platelet count and leukocyte count demonstrated good separation between mortality versus *** area under the curve（AUC） of PLT combined with WBC predicting 40-day and in-hospital mortality was 0.921 and 0.935,***:platelet count and leukocyte count combination improves the prediction of severe burn *** count and leukocyte count may be potential biomarkers for predicting mortality among patients with severe burn injury.

关键词： Severe burn Biomarker Complete blood count platelet count Mortality

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World Journal of Hepatology 2021年第5期13卷 571-583页

作者： Miwa Kawanaka Ken Nishino Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Mitsuhiko Suehiro Takako Sasai Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine Kawasaki Medical SchoolOkayama 700-8505Japan

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease and affects approximately 25%of the general global adult *** prognosis of NAFLD patients with advanced liver fibrosis is known to be *** is difficult to assess disease progression in all patients with NAFLD;thus,it is necessary to identify patients who will show poor *** To investigate the efficacy of non-invasive biomarkers for predicting disease progression in patients with *** We investigated biomarkers associated with mortality in patients with NAFLD who visited the Kawasaki Medical School General Medical Center from 1996 to 2018 and underwent liver biopsy and had been followed-up for>1 *** overall mortality and liver-related events during follow-up were calculated using the Kaplan-Meier analysis and compared using log-rank *** calculated the odds ratio and performed receiver operating characteristic curve analysis with logistic regression analysis to determine the optimal cut-off value with the highest prognostic *** We enrolled 489 patients who were followed-up for a period of 1-22.2 *** total,13 patients died(2.7%of total patients enrolled);7 patients died due to liverrelated *** prognosis was associated with liver fibrosis on histological examination but not with inflammation or *** biomarkers associated with mortality were platelet counts,albumin levels,and type IV collagen 7S *** optimal cutoff index for predicting total mortality was a platelet count of 15×10^(4)/μL,albumin level of 3.5 g/dL,and type IV collagen 7S level of 5 mg/*** particular,only one-factor patients with NAFLD presenting with platelet counts≤15×10^(4)/μL,albumin levels≤3.5 g/dL,or type IV collagen 7S≥5 mg/dL showed 5-year,10-year,and 15-year survival rates of 99.7%,98.3%,and 94%,***,patients with two factors had lower 5-year and 10-year survival rates of 98%and 43%,respect

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis platelet count Albumin Type IV collagen 7S All-cause mortality

Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin Chen En-Da Yu Chao-Yu Miao Department of Colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of Endocrinology and Metabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been *** the popularization of endoscopic technology,a number of early CRC has been ***,despite current treatment methods,some patients with early CRC still experience postoperative recurrence and *** To search for indicators associated with early CRC recurrence and metastasis to identify high-risk *** A total of 513 patients with pT2N0M0 or pT3N0M0 CRC were retrospectively enrolled in this *** of blood routine test,liver and kidney function tests and tumor markers were collected before *** were followed up through disease-specific database and telephone *** recurrence,metastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and *** We comprehensively compared the predictive value of preoperative blood routine,blood biochemistry and tumor markers for disease-free survival(DFS)and overall survival(OS)of *** multivariate analysis demonstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum carcinoembryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for *** cutoff value of serum CEA level for predicting OS was 2.74 ng/*** the OS of CRC patients with serum CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0M0 or T3N0M0 CRC,preoperative platelet count was a protective factor for DFS,while serum CEA level was an independent risk factor for *** that these measures are easier to detect and more acceptable to patients,they may have broader applications.

关键词： Colorectal cancer platelet count Serum carcinoembryonic antigen Total cholesterol level Overall survival Disease-free survival

Analysis of prognostic factors in patients with emergency sepsis

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世界临床病例杂志 2023年第25期11卷 5903-5909页

作者： Xian-Li Ning Min Shao Department of Emergency Anqing Municipal HospitalAnqing 246000Anhui ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina

BACKGROUND Emergency sepsis is a common and serious infectious disease,and its prognosis is influenced by a number of *** To analyse the factors influencing the prognosis of patients with emergency sepsis in order to provide a basis for individualised patient treatment and *** retrospectively analysing the clinical data collected,we conducted a comprehensive analysis of factors such as age,gender,underlying disease,etiology and site of infection,inflammatory indicators,multi-organ failure,cardiovascular function,therapeutic measures,immune status and severity of *** Data collection:Clinical data were collected from patients diagnosed with acute sepsis,including basic information,laboratory findings,medical history and treatment *** selection:Variables associated with prognosis were selected,including age,gender,underlying disease,etiology and site of infection,inflammatory indicators,multi-organ failure,cardiovascular function,treatment measures,immune status and severity of *** analysis:The data collected are analysed using appropriate statistical methods such as multiple regression analysis and survival *** impact of each factor on prognosis was assessed according to prognostic indicators,such as survival,length of stay and complication *** Descriptive statistics:Descriptive statistics were performed on the data collected from the patients,including their basic characteristics and clinical *** Type 2 diabetes mellitus were independent factors affecting the prognosis of patients with sepsis.

关键词： platelet count Length of ICU stay Mechanical ventilation Abdominal infection Combined coronary artery disease

Prediction of effective percutaneous transhepatic biliary drainage in patients with hepatocellular carcinoma: A multi-central retrospective study

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Liver Research 2022年第4期6卷 269-275页

作者： Haofan Wang Yitao Mao Chunning Zhang Xiaojun Hu Bin Chen Luwen Mu Shuyi Wang Yifen Lin Zhanwang Xiang Mingsheng Huang Department of Interventional Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Radiology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Oncology Maoming People's HospitalMaomingGuangdongChina Center for Interventional Medicine The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiGuangdongChina Department of Interventional Radiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Rheumatology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cardiology Department The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and aim:Percutaneous transhepatic biliary drainage(PTBD)does not always lead to a reduction in serum total bilirubin(TBil)level in patients with hepatocellular carcinoma and obstructive *** aimed to develop a model for pre-PTBD prediction of post-procedural TBil decrease in these *** and methods:Retrospective database searches were conducted at four teaching hospitals(reference period:January 2010 to December 2018),and baseline characteristics of eligible patients were *** decrease in TBil after PTBD and the lowest level of TBil post-PTBDplatelet count,and portal vein thrombosis(PVT)were predictors in the nomogram for any decrease in TBil;international normalized ratio(INR),MELD score,platelet count,and PVT were predictors for a decrease toplatelet count,and PVT were predictors for a decrease toplatelet count,and pre-albumin level were predictors for a decrease to<2 mg/*** clinical value of the nomograms was proven by decision curve ***:These models may help inform clinical decision making for performing PTBD procedures.

关键词： Hepatocellular carcinoma(HCC) Percutaneous transhepatic biliary drainage (PTBD) Cholestasis Bilirubin platelet count Nomograms Predictive model

A Prognostic Model to Predict Recovery of COVID-19 Patients Based on Longitudinal Laboratory Findings

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Virologica Sinica 2020年第6期35卷 811-819页

作者： Suyan Tian Xuetong Zhu Xuejuan Sun Jinmei Wang Qi Zhou Chi Wang Li Chen Shanji Li Jiancheng Xu Division of Clinical Research First Hospital of Jilin UniversityChangchun 130021China Department of Laboratory Medicine First Hospital of Jilin UniversityChangchun 130021China Department of Laboratory Medicine Changchun Infectious Disease HospitalChangchun 130123China Department of Laboratory Medicine Siping Infectious Disease HospitalSiping 136099China Department of Pediatrics First Hospital of Jilin UniversityChangchun 130021China Department of Internal Medicine College of MedicineUniversity of KentuckyLexingtonKY 40536USA Department of Laboratory Medicine Jilin Infectious Disease HospitalJilin 132011China

The temporal change patterns of laboratory data may provide insightful clues into the whole course of *** study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19,and identify independent prognostic factors by examining the associations between laboratory findings and outcomes of *** multicenter study included 56 patients with COVID-19 treated in Jilin Province,China,from January 21,2020 to March 5,*** laboratoryfindings,epidemiological characteristics and demographic data were extracted from electronic medical *** average value of eosinophils and carbon dioxide combining power continued to significantly increase,while the average value of cardiac troponin I and mean platelet volume decreased throughout the course of the *** average value of lymphocytes approached the lower limit of the reference interval for the first 5 days and then rose slowly *** average value of thrombocytocrit peaked on day 7 and slowly declined *** average value of mean corpuscular volume and serum sodium showed an upward trend from day 8 and day 15,***,sex,lactate dehydrogenase,platelet count and globulin level were included in the final model to predict the probability of *** above parameters were verified in 24 patients with COVID-19 in another area of Jilin *** risk stratification and management of patients with COVID-19 could be improved according to the temporal trajectories of laboratory tests.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) platelet count Lactate dehydrogenase Globulin

Laparoscopic splenectomy for immune thrombocytopenic purpura at a teaching institution

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Chinese Medical Journal 2011年第8期124卷 1175-1180页

作者： ZHENG Chao-xu ZHENG Dong CHEN Liu-hua YU Jun-feng WU Zhi-mian Department of General Surgery the First Affiliated Hospital Sun Yat-sen University GuangzhouGuangdong 510080 China Department of Hematology the First Affiliated Hospital Sun Yat-sen -University GuangzhouGuangdong 510080 China

Background High anatomic location, fragility, and generous blood supply of the spleen makes laparoscopic splenectomy （LS） difficult to master, and few patients need splenectomy for benign disorders. The aim of this research was to assess operative outcomes and hematological results of a large series of patients treated with LS for chronic immune thrombocytopenic purpura （ITP） and to determine which clinical variables predict favorable hematological *** LS was successfully performed for 154 patients with chronic ITP from September 1999 to April 2009 at the First Affiliated Hospital of Sun Yat-sen University. Operative outcomes were assessed retrospectively. Long-term follow-up data were obtained from outpatient medical records and phone interviews. Clinical and laboratory variables （including gender, age, disease duration before surgery, previous response to steroids, preoperative platelet count, and postoperative peak platelet count） were evaluated by univariate analysis to identify potential predictors of hematological outcome. Multivariate Logistic regression model was used to determine independent predictors of hematological *** One patient died from subphrenic abscess and postoperative sepsis. The overall major morbidity rate was 8.4%. None of the patients required a second surgery for complications. Of the 127 patients available for a mean follow-up of 43.6 months （range 9-114 months）, the overall initial response （i.e., at two months after LS） and long-term response to LS were achieved in 89.0% and 80.3%, respectively. Five patients （3.9%） developed pneumonia 3-35 months after LS. Univariate analysis showed a significant difference in mean age between responders （29.1 years） and nonresponders （38.8 years; P ＜0.05）. Patients who responded to steroid therapy had better hematological outcome than those who did not respond （P ＜0.05）. Compared to nonresponders, responders to LS had a significantly higher postoperative peak platelet count （40

关键词： laparoscopic splenectomy immune thrombocytopenic purpura follow-up treatment outcome platelet count

Use of platelet Indices for Determining Illness Severity and Predicting Prognosis in Critically III Patients

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Chinese Medical Journal 2015年第15期128卷 2012-2018页

作者： Sheng Zhang Yun-Liang Cui Meng-Yuan Diao Deng-Chang Chen Zhao-Fen Lin Department of Emergency Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China Department of Critical Care Medicine Jinan Military General Hospital Jinan Shandong 250031 China Department of Outpatient Naval Logistics Branch of Hangzhou Sanatorium Nanjing Military Area CommandHangzhou Zhejiang 310002 China

Background：Decreased platelet （PLT） count is one of the independent risk factors for mortality in intensive care unit （ICU） *** study was to investigate the relationship between PLT indices and illness severity and their performances in predicting hospital ***：Adult patients who admitted to ICU of Changzheng Hospital from January 2011 to September 2012 and met inclusion criteria were included in this *** analysis was used to identify potential independent risk factors for *** logistic regression analysis was used to calculate adjusted odds ratio for mortality in patients with normal or abnormal PLT *** relationship between PLT indices and illness severity were assessed by the Acute Physiology and Chronic Health Evaluation Ⅱ （APACHE Ⅱ） scores or sequential organ failure assessment （SOFA） scores in patients with normal and abnormal PLT *** performances of PLT indices in predicting mortality were assessed by receiver operating curves and diagnostic *** survival curves between patients with normal and abnormal PLT indices were compared using Kaplan-Meier ***：From January 2011 to September 2012,261 of 361 patients （204 survivors and 57 nonsurvivors） met the inclusion *** adjustment for clinical variables,PLT count 〈 100 × 10^12/L （P =0.011）,plateletcrit （PCT）〈0.108 （P =0.002）,mean platelet volume （MPV）〉11.3 fL （P =0.023） and platelet distribution width （PDW） percentage 〉17% （P =0.009） were identified as independent risk factors for *** APACHE Ⅱ and SOFA scores were 14.0 （9.0-20.0） and 7.0 （5.0-10.5） in the ＂low PLT＂ tertile,13.0 （8.0-16.0） and 7.0 （4.0-11.0） in the ＂low PCT＂ tertile,14.0 （9.3-19.0） and 7.0 （4.0-9.8） in the ＂high MPV＂ tertile,14.0 （10.5-20.0） and 7.0 （5.0-11.0） in the ＂high PDW＂ tertile,all of which were higher than those in patients with normal *** with decreased PLT and PCT values （all P 〈 0.001）,or increased MPV and PDW values （

关键词： Mean platelet Volume platelet count platelet Distribution Width platelet Indices plateletcrit

Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features

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Open Journal of Obstetrics and Gynecology 2023年第2期13卷 153-165页

作者： Mohammed Mahmoud Samy Ahmed Nagy Abdul-Rahman Younis Karim Mohammed Labib Departmenrt of Obstetrics and Gynecology Faculty of Medicine Ain Shams University Cairo Egypt Ain Shams University Cairo Egypt

Background: Pre-eclampsia (PE), a complex, multisystem, pregnancy-associated hypertensive disorder, typically developing after the 20th week of gestation, that complicates 2% - 8% of pregnancies, is a leading cause of neonatal and maternal mortality and morbidity. Aim of the Work: To identify different factors predicting transformation of non-severe pre-eclampsia in to pre-eclampsia with severe features. Patients and Methods: This prospective cohort study was conducted at tertiary care hospital at Ain Shams University hospitals from June 2021 till January 2022 and performed on total of 100 patients who diagnosed as non-severe pre-eclampsia after exclusion of severity features. Results: The current study revealed that transformation to severe pre-eclampsia occurred in 33% of the studied cases. Body mass index (BMI), past and family histories of preeclampsia statistically were significantly higher in cases transformed into preeclampsia with severe features. Admission blood pressure, albumin dipstick, Oligohydramnios and IUGR statistically were significantly higher in cases with transformation from non-severe pre-eclampsia into pre-eclampsia with severe features. platelet count statistically was significantly lower in cases with transformation from non-severe pre-eclampsia into pre-eclampsia with severe features Conclusion: Our study results identified the most important clinical risk factors for transformation to severe features of pre-eclampsia from non-severe features and provided new information on the level of risk associated with specific combinations of risk factors (BMI ≥ 35.4, admission systolic blood pressure, admission diastolic blood pressure, albumin dipstick 4+ and platelets count) with low significant diagnostic performance in predicting transformation from non-severe pre-eclampsia into pre-eclampsia with severe features.

关键词： Pre-Eclampsia Blood Pressure Body Mass Index platelet count