Pre-mobilization platelet count predicts stem cell yield during mobilization in patients with multiple myeloma
Pre-mobilization platelet count predicts stem cell yield during mobilization in patients with multiple myeloma作者机构：Hematology DepartmentBeijing Jishuitan HospitalBeijing 100035China
出 版 物：《Cancer Pathogenesis and Therapy》 (癌症发生与治疗（英文）)
年 卷 期：2023年第1卷第1期
页 面：40-45页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Platelet count Hematopoietic stem cell collection Multiple myeloma
摘 要：Background Autologous hematopoietic stem cell(HSC)transplantation remains the recommended treatment for eligible patients with multiple myeloma(MM).Increasing the number of transplanted CD34^(+)cells shorten the time to hematopoietic reconstitution and increases the overall survival of *** the harvest of a sufficient CD34^(+)cell number being crucial,this study aimed to predict the factors that affect stem cell *** We conducted a retrospective study of 110 patients who were newly diagnosed with MM and underwent autologous HSC collection at Beijing Jishuitan Hospital between March 2016 and July *** factors were analyzed using the Mann-Whitney U tests for between-group *** were considered statistically significant at P*** We found that patient age affected stem cell collection significantly;for patients younger than 55 years,the number of CD34^(+)cells harvested may be≥2×10^(6)/L,is unlikely to reach 5×10^(6)/*** count at initial mobilization was a predictor of the number of CD34^(+)cells *** may fail when the platelet count at initial mobilization is below 17×10^(9)/L and may be excellent when it is higher than 199×10^(9)/*** This finding could guide us to predict the approximate number of CD34^(+)cells collected in advance during autologous transplant mobilization for MM and to decide in advance whether to apply plerixafor to improve the number of HSCs collected.
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