检索结果-南通市图书馆

Respiratory Plasticity following spinal cord injury:perspectives from mouse to man

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第10期17卷 2141-2148页

作者： Katherine C.Locke Margo L.Randelman Daniel J.Hoh Lyandysha V.Zholudeva Michael A.Lane Department of Neurobiology&Anatomy Drexel UniversityPhiladelphiaPAUSA Marion Murray Spinal Cord Research Center PhiladelphiaPAUSA Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFLUSA Cardiovascular Disease Gladstone InstitutesSan FranciscoCAUSA

The study of respiratory Plasticity in animal models spans decades.At the bench,researchers use an array of techniques aimed at harnessing the power of Plasticity within the central nervous system to restore respiration following spinal cord injury.This field of research is highly clinically relevant.People living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3-C5 typically have significant impairments in breathing which may require assisted ventilation.Those who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life expectancy.Pre-clinical research examining respiratory Plasticity in animal models has laid the groundwork for clinical trials.Despite how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical barrier.The three goals of this present review are to define Plasticity as it pertains to respiratory function post-spinal cord injury,discuss Plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical research.By investigating current targets of respiratory Plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.

关键词： breathing phrenic Plasticity rehabilitation respiration spinal cord injury translation

Differences in action potential propagation speed and axon initial segment Plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2022年第4期43卷 615-633页

作者： Zhi-Ya Chen Luxin Peng Mengdi Zhao Yu Li Mochizuki Takahiko Louis Tao Peng Zou Yan Zhang State Key Laboratory of Membrane Biology College of Life SciencesPeking UniversityBeijing 100871China College of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules CenterBeijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationPeking UniversityBeijing 100871China Center for Quantitative Biology Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Center for Bioinformatics National Laboratory of Protein Engineering and Plant Genetic EngineeringSchool of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Beijing Academy of Artificial Intelligence Beijing 100084China Chinese Institute for Brain Research(CIBR) Beijing 102206China

Action potentials(APs)in neurons are generated at the axon initial segment(AIS).AP dynamics,including initiation and propagation,are intimately associated with neuronal excitability and neurotransmitter release kinetics.Most learning and memory studies at the single-neuron level have relied on the use of animal models,most notably rodents.Here,we studied AP initiation and propagation in cultured hippocampal neurons from Sprague-Dawley(SD)rats and C57BL/6(C57)mice with genetically encoded voltage indicator(GEVI)-based voltage imaging.Our data showed that APs traveled bidirectionally in neurons from both species;forward-propagating APs(fpAPs)had a different speed than backpropagating APs(bpAPs).Additionally,we observed distinct AP propagation characteristics in AISs emerging from the somatic envelope compared to those originating from dendrites.Compared with rat neurons,mouse neurons exhibited higher bpAP speed and lower fpAP speed,more distally located ankyrin G(AnkG)in AISs,and longer Nav1.2 lengths in AISs.Moreover,during AIS Plasticity,AnkG and Nav1.2 showed distal shifts in location and shorter lengths of labeled AISs in rat neurons;in mouse neurons,however,they showed a longer AnkG-labeled length and more distal Nav1.2 location.Our findings suggest that hippocampal neurons in SD rats and C57 mice may have different AP propagation speeds,different AnkG and Nav1.2 patterns in the AIS,and different AIS Plasticity properties,indicating that comparisons between these species must be carefully considered.

关键词： Sprague-Dawley rats C57BL/6 mice Action potential Axon initial segment Plasticity

Pathogen-associated T follicular helper cell Plasticity is critical in anti-viral immunity

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2022年第6期65卷 1075-1090页

作者： Han Feng Xiaohong Zhao Jenny Xie Xue Bai Weiwei Fu Hairong Chen Hong Tang Xiaohu Wang Chen Dong Institute for Immunology Tsinghua UniversityBeijing 100084China Discovery Immunology Bristol Myers SquibbPrinceton NJ 08543USA Department of Gastroenterology Peking University Third HospitalBeijing 100191China CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of ScienceBeijing 100101China CAS Key Laboratory of Molecular Virology and Immunology Institute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200025China Pasteurien College Suzhou UniversitySuzhou 215123China Shanghai Immune Therapy Institute Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghai 200127China

T follicular helper(Tfh)cells are critical in providing help for B cells in the germinal center reaction.Tfh cell Plasticity,especially with regard to their expression of effector Th cytokines,has been described,but lacks in-depth analysis with genetic approaches.In this study,we systemically compared transcriptomic profiles of Tfh cells derived from various types of immune responses and found gene clusters corresponding to effector Th cells were differentially induced in response to pathogens or immune responses.Of special interest,a subset of Tfh cells producing IFN-γwas generated in an influenza virus infection,partially dependent on the innate cytokine IL-12.Lineage-tracing mouse model revealed unique developmental regulation of IFN-γ~+Tfh cells,while selective ablation of these cells impaired the induction of Ig G2c~+germinal center B cells and the control of influenza infection.These results indicate that pathogen-associated Tfh cell Plasticity is necessary for host immunity,which has implications in vaccine design.

关键词： T follicular helper(Tfh)cell Plasticity influenza infection IFN-γ IgG2

Improved Plasticity of Fe_(25)Co_(25)Ni_(25)(Si_(0.3)B_(0.7))_(25) High Entropy Bulk Metallic Glass through the Addition of Cu

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 417-425页

作者： Xueru Fan Lei Xie Qiang Li Chuntao Chang Hongxiang Li School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China School of Mechanical Engineering Dongguan University of TechnologyDongguan 523808China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work was focused on enhancement in the Plasticity of Fe_(25)Co_(25)Ni_(25)(Si_(0.3)B_(0.7))_(25) high entropy bulk metallic glass(HE-BMG)by adding minor Cu(0–1.2,in at.%).It is found that the appropriate addition of Cu can efficiently improve the Plasticity of the present HE-BMG while the excessive addition of Cu will deteriorate again the Plasticity,and especially,the plastic strain of the present HE-BMG is improved from 0.8%for the Cu-free alloy to 4.7%for the 0.3 at.%Cu-added alloy.The transmission electron microscopy observation shows that there are manyα-Fe(Co,Ni)clusters with sizes of less than 5 nm dispersed in the glassy matrix in the 0.3 and 0.6 at.%Cu-added alloys,which may account for the significant improvement in the Plasticity of the two alloys,and further increase in Cu content more than 0.9 at.%leads to the precipitation ofα-Fe(Co,Ni)and Fe(Co,Ni)B compound grains with diameters of tens of nanometers,in which the Plasticity of the present HE-BMGs has deteriorated rapidly.

关键词： High entropy alloys Bulk metallic glasses Glass forming ability Nano-crystallization Plasticity Microstructure

Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex Plasticity in patients with Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2023年第6期36卷 523-531页

作者： Xingxing Li Lei Chen Kunqiang Yu Wenhao Zhuang Hui Zhu Wenqiang Xu Hui Yan Gangqiao Qi Dongsheng Zhou Shaochang Wu Department of Psychiatry Ningbo Kangning Hospital&Affiliated Mental Health CentreNingbo UniversityNingboZhejiangChina Ningbo Key Laboratory for Physical Diagnosis and Treatment of Mental and Psychological Disorders Ningbo UniversityNingboZhejiangChina Department of Psychiatry Yu Yao Third People's HospitalNingboZhejiangChina Department of Psychiatry Second People's Hospital of LishuiLishuiZhejiangChina Department of Psychiatry Taizhou Second People's HospitalTaizhouZhejiangChina

Background Non-invasive brain stimulation has improved cognitive functions in patients with Alzheimer's disease(AD),and some studies suggest a close relationship between cognition and Plasticity.However,the clinical benefits of transcranial direct current stimulation(tDCS)in patients still need to be evaluated.Aims This study examined the role of tDCS in improving cognition and whether the improved cognition is related to altered cortical Plasticity.Methods 124 patients with AD were randomly assigned to active tDCS(n=63)or sham tDCS(n=61).The tDCS was applied at the dorsolateral prefrontal cortex for 30 treatment sessions across 6 weeks(5 days per week,2 days off).The Mini-Mental State Examination and the Alzheimer's Disease Assessment Scale-Cognitive(ADAS-Cog)were used for cognition evaluation at baseline,week 2 and week 6.The cortical Plasticity was represented by motor-evoked potential(MEP)measured with an electromyogram.Results The results showed thatmultiplecourses of active tDcS can improve the cognitive functions of patients with AD,especially in the memory domain(word recall,recall of test instructions and word recognition).In addition,the damaged MEP level was enhanced following active treatment.In the active tDCS group,the improvements in ADAS-Cog total and subitem(word recall and word recognition)scores were negatively correlated with the enhancement of MEP.Conclusions Our research indicates for the first time that twice-a-day tDS may improve the cognitive function of patients with AD.This study also suggests that cognitive dysfunction may be related to impaired cortical Plasticity,which warrants mechanistic investigations of the relationship between cognition and Plasticity in the future.

关键词： ADAS Plasticity function

Cell fate determination and lineage Plasticity in prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第2期25卷 149-151,F0002页

作者： Dong Gao State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Prostate cancer(PCa)initiation,progression,and therapy resistance involve genetic and epigenetic alterations that l e ad to ab err ant cel l line age specification and Plasticity.1–3 The vast majority of primary pros... 详细信息

关键词： alterations cancer Plasticity

机器学习原子运动揭示金属玻璃塑性起源:从热塑性到超声塑性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2022年第7期65卷 1952-1962页

作者：刘晓俤赫全锋卢文飞周子清田锦森梁丹丹马将杨勇沈军 College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Electromagnetic Control and Intelligent Robots Shenzhen UniversityShenzhen 518060China Department of Mechanical Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong Kong SARChina School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shanghai Engineering Research Center of Physical Vapor Deposition(PVD)Superhard Coating and Equipment Shanghai Institute of TechnologyShanghai 201418China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong Kong SARChina

金属玻璃具有无序的原子排列,但其结构与动力学并非各处均匀.许多研究证实金属玻璃的结构与动态不均匀性对于其塑性机制至关重要.金属玻璃的"缺陷"被视为结构上疏松排布、动力学上积极响应外界刺激的区域.但迄今仍未建立明确的结构-性... 详细信息

金属玻璃具有无序的原子排列,但其结构与动力学并非各处均匀.许多研究证实金属玻璃的结构与动态不均匀性对于其塑性机制至关重要.金属玻璃的"缺陷"被视为结构上疏松排布、动力学上积极响应外界刺激的区域.但迄今仍未建立明确的结构-性能关系来甄别金属玻璃中的类液缺陷.本文中,我们基于模拟原子运动轨迹并结合机器学习提出了一种不依赖于静态结构特征的缺陷.利用k近邻机器学习模型分析并预测了不同温度下的原子运动行为,建立了温度类标签-原子运动特征映射关系.应用这个"机器学习温度"参数理解金属玻璃在应力下的塑性流,识别类液区原子.类液区的演化揭示了金属玻璃塑性的动态起源(包括热塑性和超声塑性),展示了应力诱发的非均匀性和原子局域环境的关联,为热塑性成型和超声加工提供了新见解.

关键词： metallic glass Plasticity machine learning molecular dynamics simulation

Exploring the Effect of Plasticity on the Phase Imaging of TM-AFM Through Molecular Dynamics Simulations

在线全文

学校读者我要写书评

暂无评论

ACTA MECHANICA SOLIDA SINICA 2024年第2期37卷 297-304页

作者： Liu, Guolin Zeng, Yu Chen, Yaxin Wei, Zheng Beijing Univ Chem Technol Sch Mech & Elect Engn Beijing 100029 Peoples R China

In the tapping-mode atomic force microscope (TM-AFM), the probe tip continuously taps the sample surface, which may cause plastic deformation of the sample and result in energy dissipation. The energy dissipation of the probe is closely related to the scanned phase image. To quantify the energy dissipation due to plastic indentations of the sample, this study utilized a combination of molecular dynamics (MD) simulations and experiments on single-crystal copper samples, including multiple nano-indentation tests. The energy dissipation of the probe due to the plastic deformation of the sample was calculated by integrating the hysteresis curve of the indentation depth versus the force applied to the indenter. The simulation results are in good agreement with the experimental ones. Both sets of results have demonstrated that the plastic energy dissipation decreases as the number of indentations increases, and eventually the energy of the probe tends to stabilize. This equilibrium energy dissipation is associated with other dissipation mechanisms. Furthermore, it was observed that, after hundreds of taps, the dissipated energy of plastic deformation could be ignored, implying that the scanned image may not reflect the Plasticity information of the sample after multiple taps of the probe on the sample surface for scanning.

关键词： Atomic force microscopy Force-distance curves Nano-indentations Plasticity Molecular dynamics ENERGY-DISSIPATION

Magneto-Plasticity in micro-cutting of single-crystal copper

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第29期124卷 121-134页

作者： Yunfa Guo YanJin Lee Yu Zhang Hao Wang Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Singapore

The Plasticity of metals can be significantly affected by the application of a magnetic field,otherwise known as the magneto-plastic effect.This paper investigates the magneto-plastic effect in the microcutting of a non-magnetic ductile material,single-crystal copper,under a weak magnetic field and reports the influence of the phenomenon on the cutting forces and machined surface quality.A softening effect was observed from the large reduction in cutting forces from 3.2 N to 1.5 N under the magnetic field.As compared to the magnetic field intensity and polarity,the variation in magnetic field orientations with respect to the cutting direction exhibited a stronger influence on the cutting force,chip morphology,machined surface texture,subsurface microstructure,surface roughness,and machined surface microhardness of the copper sample.An analytical model was developed based on the geometry of the cutting chips to correlate the orientation-dependent influence of the magnetic field on the cutting forces.On the surface quality,excessive folds with four different types of morphology produced under magnetic-free cutting were suppressed after applying the magnetic field with the most significant improvement achieved with the 90°magnetic field direction.The magnetic-assisted changes in machined surface morphology also led to the reduction in machined surface roughness and microhardness.The optimistic micro-cutting outcomes in this work establish a greater understanding of the magneto-plastic effect and demonstrate the applicability of magneto-Plasticity in ultraprecision manufacturing.

关键词： Micro-cutting Magnetic field Plasticity Mechanical response Anisotropy