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Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

Chinese Journal of Natural Medicines 2022年第7期20卷 541-550页

作者： GAO Wei WANG Yi WANG Ru WANG Yi-Hai XU Jing-Wen HE Xiang-Jiu School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Engineering Research Center for Lead Compounds&Drug Discovery Guangzhou 510006China

The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal *** the current study,the antiproliferative constituents of giant taro were investigated and six new(1−6)and four known piperidine alkaloids(7−10)were isolated from its *** chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester *** isolated alkaloids were screened for the antiproliferative activity through MTT *** results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2,AGS and MCF-7 tumor *** researches showed that compounds 3−5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic *** study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.

关键词： Giant taro Alocasia macrorrhiza piperidine alkaloids Antiproliferative Apoptosis

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Study of the distribution profile of piperidine alkaloids in various parts of Prosopis juliflora by the application of Direct Analysis in Real Time Mass Spectrometry(DART-MS)

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Natural Products and Bioprospecting 2012年第5期2卷 206-209页

作者： Shachi SINGH Sanjay Kumar VERMA Center for Biotechnology Department of Biological SciencesBirla Institute of Technology and SciencePilani 333031India

Direct Analysis in Real Time Mass Spectrometry(DART-MS)was applied to identify and study the distribution profile of piperidine alkaloids in different parts of Prosopis juliflora,without isolation and separation of the compounds by standard chromatographic *** the help of DART-MS,chemical fingerprint of raw plant parts were generated,which revealed the presence of piperidine alkaloids in leaf,pod and flower.A comparative study of the distribution pattern,showed variation in the presence and distribution of these alkaloids in various parts of *** leaves and pod displayed the largest alkaloid pattern with a total of 12 different alkaloids in each part,whereas only 4 alkaloids were present in ***:julifloridine,prosopine,prosopinine and prosafrinine were ubiquitously distributed in all the alkaloid rich plant *** was pre-eminet alkaloid in leaf,whereas pod and flower displayed copious amounts of julifloridine.

关键词： DART-MS chemical fingerprint Prosopis juliflora piperidine alkaloids juliprosopine julifloridine

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