Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

作     者：GAO Wei WANG Yi WANG Ru WANG Yi-Hai XU Jing-Wen HE Xiang-Jiu GAO Wei;WANG Yi;WANG Ru;WANG Yi-Hai;XU Jing-Wen;HE Xiang-Jiu

作者机构：School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Engineering Research Center for Lead Compounds&Drug DiscoveryGuangzhou 510006China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2022年第20卷第7期

页      面：541-550页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.82173698) the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2017) the Pearl River S&T Nova Program of Guangzhou(No.201806010169) 

主　　题：Giant taro Alocasia macrorrhiza Piperidine alkaloids Antiproliferative Apoptosis 

摘      要：The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal *** the current study,the antiproliferative constituents of giant taro were investigated and six new(1−6)and four known piperidine alkaloids(7−10)were isolated from its *** chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester *** isolated alkaloids were screened for the antiproliferative activity through MTT *** results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2,AGS and MCF-7 tumor *** researches showed that compounds 3−5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic *** study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.