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Preliminary study on modelling, fabrication by photo-chemical etching and in vivo testing of biodegradable magnesium AZ31 stents

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Bioactive Materials 2021年第6期6卷 1663-1675页

作者： Bala Subramanya Pavan Kumar Kandala Guangqi Zhang Capucine LCorriveau Mark Paquin Madeleine Chagnon Dana Begun Vesselin Shanov Department of Mechanical and Materials Engineering University of CincinnatiOH45221USA Department of Chemical and Environmental Engineering University of CincinnatiOH45221USA Charles River Laboratories Montreal ULC BoisbriandQuebecJ7H 1N8Canada Medical Products Market Consulting IncIndianapolisIN46202USA Waygate Technologies Baker HughesCincinnatiOH45241USA

Magnesium metal(Mg)is a promising material for stent applications due to its biocompatibility and ability to be resorbed by the *** of stents by laser cutting has become an industry *** alternative approach uses photo-chemical etching to transfer a pattern of the stent onto a Mg *** this study,we present three stages of creating and validating a stent prototype,which includes design and simulation using finite element analysis(FEA),followed by fabrication based on AZ31 alloy and,finally,in vivo testing in peripheral arteries of domestic *** to the preliminary character of this study,only six stents were implanted in two domestic farm pigs weighing 25-28 kg and they were evaluated after 28 days,with an interim follow-up on day *** left and right superficial femoral,the left iliac,and the right renal artery were selected for this *** diameters of the stented artery segments were evaluated at the time of implantation,on day 14 and then,finally,on day 28,by quantitative vessel analysis(QVA)using fluoroscopic *** Coherence Tomography(OCT)imaging displayed some malposition,breaks,stacking,and protrusion into the lumen at the proximal,distal,and mid-sections of the stented *** stents degraded with time,but simultaneously became embedded in the *** 28 days,the animals were euthanized,and explanted vessels were fixed for micro-CT imaging and histology ***-CT imaging revealed stent morphological and volumetric changes due to the in-body *** in vivo corrosion rate of 0.75 mm/year was obtained by the CT *** histology suggested no-life threatening effects,although moderate injury,inflammation,and endothelialization scores were observed.

关键词： Magnesium alloy FEA modelling Stents photo-chemically etching Micro-CT Histology

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